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Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection: epidemiology, pathogenesis and clinical characteristics.
Eur Rev Med Pharmacol Sci. 2018 08; 22(15):4956-4961.ER

Abstract

OBJECTIVE

Middle East Respiratory Syndrome Coronavirus-(MERS-CoV) infection is an evolving worldwide health crisis. The early diagnosis and management of the disease remains a major challenge. This study designed to discuss the epidemiology, pathogenesis and clinical appearances of MERS-CoV infections.

MATERIALS AND METHODS

We conducted a broad search of the English-language literature in "PubMed" "Medline" "Web of knowledge", "EMBASE" and "Google Scholar" World Health Organization-WHO" using the key words "Middle East Respiratory Syndrome", "MERS", "MERS-CoV" "Epidemiology" "Transmission" "Pathogenesis" "Clinical Characteristics". We reviewed the literature on epidemiology, pathogenesis and clinical appearances of MERS-CoV infection and the required information was documented.

RESULTS

The global prevalence of MERS-CoV infection from June 2012 to April 2018 is 2206 people. The number of cases reported from Saudi Arabia is 1831 (83%) with mortality rate of 787 (35.67%). The main clinical manifestations are fever, chills, generalized myalgia, cough, shortness of breath, nausea, vomiting and diarrhea. The age-allied prevalence of MERS-CoV was highest amongst elderly people with chronic debilitating diseases such as pulmonary diseases, end-stage renal illness, diabetes mellitus and malignancy.

CONCLUSIONS

MERS-CoV infection is an emerging global health concern, affected people in 27 countries in the various continents. MERS-CoV infection has been identified mainly in the Middle East, Europe, Africa, Asia and North America. Early detection and management of MERS-CoV infection is of critical importance to minimize the burden of the disease.

Authors+Show Affiliations

King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi Arabia. sultanmeo@hotmail.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30070331

Citation

Nassar, M S., et al. "Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection: Epidemiology, Pathogenesis and Clinical Characteristics." European Review for Medical and Pharmacological Sciences, vol. 22, no. 15, 2018, pp. 4956-4961.
Nassar MS, Bakhrebah MA, Meo SA, et al. Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection: epidemiology, pathogenesis and clinical characteristics. Eur Rev Med Pharmacol Sci. 2018;22(15):4956-4961.
Nassar, M. S., Bakhrebah, M. A., Meo, S. A., Alsuabeyl, M. S., & Zaher, W. A. (2018). Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection: epidemiology, pathogenesis and clinical characteristics. European Review for Medical and Pharmacological Sciences, 22(15), 4956-4961. https://doi.org/10.26355/eurrev_201808_15635
Nassar MS, et al. Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection: Epidemiology, Pathogenesis and Clinical Characteristics. Eur Rev Med Pharmacol Sci. 2018;22(15):4956-4961. PubMed PMID: 30070331.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection: epidemiology, pathogenesis and clinical characteristics. AU - Nassar,M S, AU - Bakhrebah,M A, AU - Meo,S A, AU - Alsuabeyl,M S, AU - Zaher,W A, PY - 2018/8/3/entrez PY - 2018/8/3/pubmed PY - 2019/11/5/medline SP - 4956 EP - 4961 JF - European review for medical and pharmacological sciences JO - Eur Rev Med Pharmacol Sci VL - 22 IS - 15 N2 - OBJECTIVE: Middle East Respiratory Syndrome Coronavirus-(MERS-CoV) infection is an evolving worldwide health crisis. The early diagnosis and management of the disease remains a major challenge. This study designed to discuss the epidemiology, pathogenesis and clinical appearances of MERS-CoV infections. MATERIALS AND METHODS: We conducted a broad search of the English-language literature in "PubMed" "Medline" "Web of knowledge", "EMBASE" and "Google Scholar" World Health Organization-WHO" using the key words "Middle East Respiratory Syndrome", "MERS", "MERS-CoV" "Epidemiology" "Transmission" "Pathogenesis" "Clinical Characteristics". We reviewed the literature on epidemiology, pathogenesis and clinical appearances of MERS-CoV infection and the required information was documented. RESULTS: The global prevalence of MERS-CoV infection from June 2012 to April 2018 is 2206 people. The number of cases reported from Saudi Arabia is 1831 (83%) with mortality rate of 787 (35.67%). The main clinical manifestations are fever, chills, generalized myalgia, cough, shortness of breath, nausea, vomiting and diarrhea. The age-allied prevalence of MERS-CoV was highest amongst elderly people with chronic debilitating diseases such as pulmonary diseases, end-stage renal illness, diabetes mellitus and malignancy. CONCLUSIONS: MERS-CoV infection is an emerging global health concern, affected people in 27 countries in the various continents. MERS-CoV infection has been identified mainly in the Middle East, Europe, Africa, Asia and North America. Early detection and management of MERS-CoV infection is of critical importance to minimize the burden of the disease. SN - 2284-0729 UR - https://www.unboundmedicine.com/medline/citation/30070331/Middle_East_Respiratory_Syndrome_Coronavirus__MERS_CoV__infection:_epidemiology_pathogenesis_and_clinical_characteristics_ L2 - https://www.europeanreview.org/article/15635 DB - PRIME DP - Unbound Medicine ER -