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Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection: epidemiology, pathogenesis and clinical characteristics.
Eur Rev Med Pharmacol Sci. 2018 08; 22(15):4956-4961.ER

Abstract

OBJECTIVE

Middle East Respiratory Syndrome Coronavirus-(MERS-CoV) infection is an evolving worldwide health crisis. The early diagnosis and management of the disease remains a major challenge. This study designed to discuss the epidemiology, pathogenesis and clinical appearances of MERS-CoV infections.

MATERIALS AND METHODS

We conducted a broad search of the English-language literature in "PubMed" "Medline" "Web of knowledge", "EMBASE" and "Google Scholar" World Health Organization-WHO" using the key words "Middle East Respiratory Syndrome", "MERS", "MERS-CoV" "Epidemiology" "Transmission" "Pathogenesis" "Clinical Characteristics". We reviewed the literature on epidemiology, pathogenesis and clinical appearances of MERS-CoV infection and the required information was documented.

RESULTS

The global prevalence of MERS-CoV infection from June 2012 to April 2018 is 2206 people. The number of cases reported from Saudi Arabia is 1831 (83%) with mortality rate of 787 (35.67%). The main clinical manifestations are fever, chills, generalized myalgia, cough, shortness of breath, nausea, vomiting and diarrhea. The age-allied prevalence of MERS-CoV was highest amongst elderly people with chronic debilitating diseases such as pulmonary diseases, end-stage renal illness, diabetes mellitus and malignancy.

CONCLUSIONS

MERS-CoV infection is an emerging global health concern, affected people in 27 countries in the various continents. MERS-CoV infection has been identified mainly in the Middle East, Europe, Africa, Asia and North America. Early detection and management of MERS-CoV infection is of critical importance to minimize the burden of the disease.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Nassar MS
King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi Arabia. sultanmeo@hotmail.com.
Bakhrebah MA
No affiliation info available
Meo SA
No affiliation info available
Alsuabeyl MS
No affiliation info available
Zaher WA
No affiliation info available

MeSH

AdultAgedCoronavirus InfectionsDatabases, FactualDiarrheaFemaleFeverGlobal HealthHumansMaleMiddle AgedMiddle East Respiratory Syndrome CoronavirusPrevalenceSaudi ArabiaSurvival RateVomiting

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30070331

Clinical Trial Links

Primary Prevention of Infection by COVID-19 in Workers

Citation

Nassar, M S., et al. "Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection: Epidemiology, Pathogenesis and Clinical Characteristics." European Review for Medical and Pharmacological Sciences, vol. 22, no. 15, 2018, pp. 4956-4961.
Nassar MS, Bakhrebah MA, Meo SA, et al. Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection: epidemiology, pathogenesis and clinical characteristics. Eur Rev Med Pharmacol Sci. 2018;22(15):4956-4961.
Nassar, M. S., Bakhrebah, M. A., Meo, S. A., Alsuabeyl, M. S., & Zaher, W. A. (2018). Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection: epidemiology, pathogenesis and clinical characteristics. European Review for Medical and Pharmacological Sciences, 22(15), 4956-4961. https://doi.org/10.26355/eurrev_201808_15635
Nassar MS, et al. Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection: Epidemiology, Pathogenesis and Clinical Characteristics. Eur Rev Med Pharmacol Sci. 2018;22(15):4956-4961. PubMed PMID: 30070331.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection: epidemiology, pathogenesis and clinical characteristics. AU - Nassar,M S, AU - Bakhrebah,M A, AU - Meo,S A, AU - Alsuabeyl,M S, AU - Zaher,W A, PY - 2018/8/3/entrez PY - 2018/8/3/pubmed PY - 2019/11/5/medline SP - 4956 EP - 4961 JF - European review for medical and pharmacological sciences JO - Eur Rev Med Pharmacol Sci VL - 22 IS - 15 N2 - OBJECTIVE: Middle East Respiratory Syndrome Coronavirus-(MERS-CoV) infection is an evolving worldwide health crisis. The early diagnosis and management of the disease remains a major challenge. This study designed to discuss the epidemiology, pathogenesis and clinical appearances of MERS-CoV infections. MATERIALS AND METHODS: We conducted a broad search of the English-language literature in "PubMed" "Medline" "Web of knowledge", "EMBASE" and "Google Scholar" World Health Organization-WHO" using the key words "Middle East Respiratory Syndrome", "MERS", "MERS-CoV" "Epidemiology" "Transmission" "Pathogenesis" "Clinical Characteristics". We reviewed the literature on epidemiology, pathogenesis and clinical appearances of MERS-CoV infection and the required information was documented. RESULTS: The global prevalence of MERS-CoV infection from June 2012 to April 2018 is 2206 people. The number of cases reported from Saudi Arabia is 1831 (83%) with mortality rate of 787 (35.67%). The main clinical manifestations are fever, chills, generalized myalgia, cough, shortness of breath, nausea, vomiting and diarrhea. The age-allied prevalence of MERS-CoV was highest amongst elderly people with chronic debilitating diseases such as pulmonary diseases, end-stage renal illness, diabetes mellitus and malignancy. CONCLUSIONS: MERS-CoV infection is an emerging global health concern, affected people in 27 countries in the various continents. MERS-CoV infection has been identified mainly in the Middle East, Europe, Africa, Asia and North America. Early detection and management of MERS-CoV infection is of critical importance to minimize the burden of the disease. SN - 2284-0729 UR - https://www.unboundmedicine.com/medline/citation/30070331/Middle_East_Respiratory_Syndrome_Coronavirus__MERS_CoV__infection:_epidemiology_pathogenesis_and_clinical_characteristics_ DB - PRIME DP - Unbound Medicine ER -