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Body iron status of children and adolescents with transfusion dependent β-thalassaemia: trends of serum ferritin and associations of optimal body iron control.
BMC Res Notes 2018; 11(1):547BR

Abstract

OBJECTIVE

This cross sectional study aims to describe the body iron status, trends of serum ferritin and associations of optimal body iron control in patients aged below 16 years with transfusion dependent β-thalassaemia attending Paediatric and Adolescent Thalassaemia Centres of the Colombo North Teaching Hospital of Sri Lanka.

RESULTS

Out of 54 children, 51% were males and a majority were aged 11-16 years; 83% had β-thalassaemia major while 13% had HbE β-thalassaemia. Mean serum ferritin was 1778(± 1458) µg/l and 29% had optimal serum ferritin (below 1000 µg/l). Trend of mean serum ferritin over time showed gradual decline between 2011 and 2017 and longitudinal trend of individual patients at yearly intervals showed gradual rise until 5 years of age and plateauing thereafter. All except two patients were receiving iron chelator medication of which the most commonly used was oral deferasirox (92%). The most common iron-related complications were short stature (24.1%) and pubertal delay (42.8% of > 14 years). None of the patients had hypothyroidism, hypoparathyroidism or diabetes. Optimal serum ferritin levels were significantly associated with the diagnosis of thalassaemia at a later age (23.6 vs 9.0 months) and higher family income (OR-4.81;95%CI 1.17-19.67) however was not associated with the age of the patient or duration of transfusion.

Authors+Show Affiliations

Colombo North Teaching Hospital, Ragama, Sri Lanka.Department of Paediatrics, Faculty of Medicine, University of Kelaniya, Thalagolla Road, Ragama, 11010, Sri Lanka.Department of Pharmacology, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.Colombo North Teaching Hospital, Ragama, Sri Lanka. Department of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.Colombo North Teaching Hospital, Ragama, Sri Lanka. sachith.mettananda@kln.ac.lk. Department of Paediatrics, Faculty of Medicine, University of Kelaniya, Thalagolla Road, Ragama, 11010, Sri Lanka. sachith.mettananda@kln.ac.lk.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30071883

Citation

Suriapperuma, Tharindi, et al. "Body Iron Status of Children and Adolescents With Transfusion Dependent Β-thalassaemia: Trends of Serum Ferritin and Associations of Optimal Body Iron Control." BMC Research Notes, vol. 11, no. 1, 2018, p. 547.
Suriapperuma T, Peiris R, Mettananda C, et al. Body iron status of children and adolescents with transfusion dependent β-thalassaemia: trends of serum ferritin and associations of optimal body iron control. BMC Res Notes. 2018;11(1):547.
Suriapperuma, T., Peiris, R., Mettananda, C., Premawardhena, A., & Mettananda, S. (2018). Body iron status of children and adolescents with transfusion dependent β-thalassaemia: trends of serum ferritin and associations of optimal body iron control. BMC Research Notes, 11(1), p. 547. doi:10.1186/s13104-018-3634-9.
Suriapperuma T, et al. Body Iron Status of Children and Adolescents With Transfusion Dependent Β-thalassaemia: Trends of Serum Ferritin and Associations of Optimal Body Iron Control. BMC Res Notes. 2018 Aug 2;11(1):547. PubMed PMID: 30071883.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Body iron status of children and adolescents with transfusion dependent β-thalassaemia: trends of serum ferritin and associations of optimal body iron control. AU - Suriapperuma,Tharindi, AU - Peiris,Ravindu, AU - Mettananda,Chamila, AU - Premawardhena,Anuja, AU - Mettananda,Sachith, Y1 - 2018/08/02/ PY - 2018/06/28/received PY - 2018/07/20/accepted PY - 2018/8/4/entrez PY - 2018/8/4/pubmed PY - 2019/1/4/medline KW - Chelation KW - Iron overload KW - Serum ferritin KW - Transfusion dependent β-thalassaemia SP - 547 EP - 547 JF - BMC research notes JO - BMC Res Notes VL - 11 IS - 1 N2 - OBJECTIVE: This cross sectional study aims to describe the body iron status, trends of serum ferritin and associations of optimal body iron control in patients aged below 16 years with transfusion dependent β-thalassaemia attending Paediatric and Adolescent Thalassaemia Centres of the Colombo North Teaching Hospital of Sri Lanka. RESULTS: Out of 54 children, 51% were males and a majority were aged 11-16 years; 83% had β-thalassaemia major while 13% had HbE β-thalassaemia. Mean serum ferritin was 1778(± 1458) µg/l and 29% had optimal serum ferritin (below 1000 µg/l). Trend of mean serum ferritin over time showed gradual decline between 2011 and 2017 and longitudinal trend of individual patients at yearly intervals showed gradual rise until 5 years of age and plateauing thereafter. All except two patients were receiving iron chelator medication of which the most commonly used was oral deferasirox (92%). The most common iron-related complications were short stature (24.1%) and pubertal delay (42.8% of > 14 years). None of the patients had hypothyroidism, hypoparathyroidism or diabetes. Optimal serum ferritin levels were significantly associated with the diagnosis of thalassaemia at a later age (23.6 vs 9.0 months) and higher family income (OR-4.81;95%CI 1.17-19.67) however was not associated with the age of the patient or duration of transfusion. SN - 1756-0500 UR - https://www.unboundmedicine.com/medline/citation/30071883/Body_iron_status_of_children_and_adolescents_with_transfusion_dependent_β_thalassaemia:_trends_of_serum_ferritin_and_associations_of_optimal_body_iron_control_ L2 - https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-018-3634-9 DB - PRIME DP - Unbound Medicine ER -