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Nail abnormalities identified in an ageing study of 30 inbred mouse strains.
Exp Dermatol 2019; 28(4):383-390ED

Abstract

In a large-scale ageing study, 30 inbred mouse strains were systematically screened for histologic evidence of lesions in all organ systems. Ten strains were diagnosed with similar nail abnormalities. The highest frequency was noted in NON/ShiLtJ mice. Lesions identified fell into two main categories: acute to chronic penetration of the third phalangeal bone through the hyponychium with associated inflammation and bone remodelling or metaplasia of the nail matrix and nail bed associated with severe orthokeratotic hyperkeratosis replacing the nail plate. Penetration of the distal phalanx through the hyponychium appeared to be the initiating feature resulting in nail abnormalities. The accompanying acute to subacute inflammatory response was associated with osteolysis of the distal phalanx. Evaluation of young NON/ShiLtJ mice revealed that these lesions were not often found, or affected only one digit. The only other nail unit abnormality identified was sporadic subungual epidermoid inclusion cysts which closely resembled similar lesions in human patients. These abnormalities, being age-related developments, may have contributed to weight loss due to impacts upon feeding and should be a consideration for future research due to the potential to interact with other experimental factors in ageing studies using the affected strains of mice.

Authors+Show Affiliations

The Ohio State University College of Veterinary Medicine, Columbus, Ohio.Purdue University College of Veterinary Medicine, West Lafayette, Indiana.The Jackson Laboratory, Bar Harbor, Maine.The Jackson Laboratory, Bar Harbor, Maine.The Jackson Laboratory, Bar Harbor, Maine.The Jackson Laboratory, Bar Harbor, Maine.Computational Bioscience Research Center, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.Computational Bioscience Research Center, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.The Jackson Laboratory, Bar Harbor, Maine. Department of Physiology Development and Neuroscience, University of Cambridge, Cambridge, UK.The Jackson Laboratory, Bar Harbor, Maine.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30074290

Citation

Linn, Sarah C., et al. "Nail Abnormalities Identified in an Ageing Study of 30 Inbred Mouse Strains." Experimental Dermatology, vol. 28, no. 4, 2019, pp. 383-390.
Linn SC, Mustonen AM, Silva KA, et al. Nail abnormalities identified in an ageing study of 30 inbred mouse strains. Exp Dermatol. 2019;28(4):383-390.
Linn, S. C., Mustonen, A. M., Silva, K. A., Kennedy, V. E., Sundberg, B. A., Bechtold, L. S., ... Sundberg, J. P. (2019). Nail abnormalities identified in an ageing study of 30 inbred mouse strains. Experimental Dermatology, 28(4), pp. 383-390. doi:10.1111/exd.13759.
Linn SC, et al. Nail Abnormalities Identified in an Ageing Study of 30 Inbred Mouse Strains. Exp Dermatol. 2019;28(4):383-390. PubMed PMID: 30074290.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nail abnormalities identified in an ageing study of 30 inbred mouse strains. AU - Linn,Sarah C, AU - Mustonen,Allison M, AU - Silva,Kathleen A, AU - Kennedy,Victoria E, AU - Sundberg,Beth A, AU - Bechtold,Lesley S, AU - Alghamdi,Sarah, AU - Hoehndorf,Robert, AU - Schofield,Paul N, AU - Sundberg,John P, Y1 - 2018/09/04/ PY - 2018/03/23/received PY - 2018/07/27/accepted PY - 2020/04/01/pmc-release PY - 2018/8/4/pubmed PY - 2018/8/4/medline PY - 2018/8/4/entrez KW - nail dystrophy KW - pododermatitis circumscripta KW - subungual intraosseous epidermoid inclusion cysts SP - 383 EP - 390 JF - Experimental dermatology JO - Exp. Dermatol. VL - 28 IS - 4 N2 - In a large-scale ageing study, 30 inbred mouse strains were systematically screened for histologic evidence of lesions in all organ systems. Ten strains were diagnosed with similar nail abnormalities. The highest frequency was noted in NON/ShiLtJ mice. Lesions identified fell into two main categories: acute to chronic penetration of the third phalangeal bone through the hyponychium with associated inflammation and bone remodelling or metaplasia of the nail matrix and nail bed associated with severe orthokeratotic hyperkeratosis replacing the nail plate. Penetration of the distal phalanx through the hyponychium appeared to be the initiating feature resulting in nail abnormalities. The accompanying acute to subacute inflammatory response was associated with osteolysis of the distal phalanx. Evaluation of young NON/ShiLtJ mice revealed that these lesions were not often found, or affected only one digit. The only other nail unit abnormality identified was sporadic subungual epidermoid inclusion cysts which closely resembled similar lesions in human patients. These abnormalities, being age-related developments, may have contributed to weight loss due to impacts upon feeding and should be a consideration for future research due to the potential to interact with other experimental factors in ageing studies using the affected strains of mice. SN - 1600-0625 UR - https://www.unboundmedicine.com/medline/citation/30074290/Nail_abnormalities_identified_in_an_ageing_study_of_30_inbred_mouse_strains L2 - https://doi.org/10.1111/exd.13759 DB - PRIME DP - Unbound Medicine ER -