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Investigating the possible causal association of coffee consumption with osteoarthritis risk using a Mendelian randomization analysis.
Clin Rheumatol 2018; 37(11):3133-3139CR

Abstract

This study examined whether coffee consumption is causally associated with osteoarthritis. A two-sample Mendelian randomization (MR) analysis using inverse-variance weighted (IVW) and weighted median estimates, and the MR-Egger regression method were performed. The publicly available summary statistical datasets of coffee consumption genome-wide association studies (GWASs) meta-analyses on coffee intake from eight Caucasian cohorts (n = 18,176), GWAS meta-analyses of predominately regular-type coffee consumers of European ancestry (n = up to 91,462), and a GWAS in 7410 patients with osteoarthritis in the arcOGEN study with 11,009 controls of European ancestry were evaluated. Four single-nucleotide polymorphisms (SNPs) from GWASs of coffee consumption as instrumental variables (IVs) to improve inference were selected. These SNPs were located at neurocalcin delta (NCALD) (rs16868941), cytochrome p450 oxidoreductase (POR) (rs17685), cytochrome p450 family 1 subfamily A member 1 (CYP1A1) (rs2470893), and neuronal cell adhesion molecule (NRCAM) (rs382140). The IVW method (beta = 0.381, SE = 0.170, p = 0.025) and the weighted median approach (beta = 0.419, SE = 0.206, p = 0.047) showed evidence to support a causal association between coffee consumption and osteoarthritis. MR-Egger regression revealed that directional pleiotropy was unlikely to be biasing the result (intercept = 0.064; p = 0.549), but showed no causal association between coffee consumption and osteoarthritis (beta = - 0.518, SE = 1.270, p = 0.723). Cochran's Q test and the funnel plot indicated no evidence of heterogeneity between IV estimates based on the individual variants. The results of MR analysis support the observation that coffee consumption is causally associated with an increased risk of osteoarthritis.

Authors+Show Affiliations

Department of Rheumatology, Korea University College of Medicine, Korea University Anam Hospital, 73, Inchon-ro, Seongbuk-gu, Seoul, 02841, South Korea. lyhcgh@korea.ac.kr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30076541

Citation

Lee, Young Ho. "Investigating the Possible Causal Association of Coffee Consumption With Osteoarthritis Risk Using a Mendelian Randomization Analysis." Clinical Rheumatology, vol. 37, no. 11, 2018, pp. 3133-3139.
Lee YH. Investigating the possible causal association of coffee consumption with osteoarthritis risk using a Mendelian randomization analysis. Clin Rheumatol. 2018;37(11):3133-3139.
Lee, Y. H. (2018). Investigating the possible causal association of coffee consumption with osteoarthritis risk using a Mendelian randomization analysis. Clinical Rheumatology, 37(11), pp. 3133-3139. doi:10.1007/s10067-018-4252-6.
Lee YH. Investigating the Possible Causal Association of Coffee Consumption With Osteoarthritis Risk Using a Mendelian Randomization Analysis. Clin Rheumatol. 2018;37(11):3133-3139. PubMed PMID: 30076541.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Investigating the possible causal association of coffee consumption with osteoarthritis risk using a Mendelian randomization analysis. A1 - Lee,Young Ho, Y1 - 2018/08/03/ PY - 2018/07/02/received PY - 2018/07/30/accepted PY - 2018/07/22/revised PY - 2018/8/5/pubmed PY - 2018/8/5/medline PY - 2018/8/5/entrez KW - Coffee KW - Mendelian randomization KW - Osteoarthritis SP - 3133 EP - 3139 JF - Clinical rheumatology JO - Clin. Rheumatol. VL - 37 IS - 11 N2 - This study examined whether coffee consumption is causally associated with osteoarthritis. A two-sample Mendelian randomization (MR) analysis using inverse-variance weighted (IVW) and weighted median estimates, and the MR-Egger regression method were performed. The publicly available summary statistical datasets of coffee consumption genome-wide association studies (GWASs) meta-analyses on coffee intake from eight Caucasian cohorts (n = 18,176), GWAS meta-analyses of predominately regular-type coffee consumers of European ancestry (n = up to 91,462), and a GWAS in 7410 patients with osteoarthritis in the arcOGEN study with 11,009 controls of European ancestry were evaluated. Four single-nucleotide polymorphisms (SNPs) from GWASs of coffee consumption as instrumental variables (IVs) to improve inference were selected. These SNPs were located at neurocalcin delta (NCALD) (rs16868941), cytochrome p450 oxidoreductase (POR) (rs17685), cytochrome p450 family 1 subfamily A member 1 (CYP1A1) (rs2470893), and neuronal cell adhesion molecule (NRCAM) (rs382140). The IVW method (beta = 0.381, SE = 0.170, p = 0.025) and the weighted median approach (beta = 0.419, SE = 0.206, p = 0.047) showed evidence to support a causal association between coffee consumption and osteoarthritis. MR-Egger regression revealed that directional pleiotropy was unlikely to be biasing the result (intercept = 0.064; p = 0.549), but showed no causal association between coffee consumption and osteoarthritis (beta = - 0.518, SE = 1.270, p = 0.723). Cochran's Q test and the funnel plot indicated no evidence of heterogeneity between IV estimates based on the individual variants. The results of MR analysis support the observation that coffee consumption is causally associated with an increased risk of osteoarthritis. SN - 1434-9949 UR - https://www.unboundmedicine.com/medline/citation/30076541/Investigating_the_possible_causal_association_of_coffee_consumption_with_osteoarthritis_risk_using_a_Mendelian_randomization_analysis_ L2 - https://dx.doi.org/10.1007/s10067-018-4252-6 DB - PRIME DP - Unbound Medicine ER -