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Cost-effectiveness estimates of vaccination against rotavirus in Piedmont, Italy.
J Infect Public Health. 2018 Nov - Dec; 11(6):867-872.JI

Abstract

BACKGROUND

Rotavirus-induced gastroenteritis (RVGE) represents the most frequent form of severe gastroenteritis in children. In such a scenario, the availability of an efficient anti-Rotavirus (anti-RV) vaccine represents an effective prevention tool able to prevent those complications mainly linked to the moderate-severe forms of this disease, which require hospital care. The aim of the present study is to estimate the cost effectiveness of universal routine infant RV vaccination program and its budget impact on the Regional Health Service (RHS) of Piedmont, Italy, in order to evaluate the opportunity of the implementation of a national anti-Rotavirus vaccination programme.

METHODS

The researchers performed a cost-effectiveness analysis comparing costs and benefits of a Rotarix two-dose vaccination versus non vaccination and a budget impact analysis (BIA), complementary to the cost-effectiveness analysis.

RESULTS

Our results show that the mass implementation of an anti-RV vaccination in Piedmont, in addition to the expected public health benefits, also allows the RHS to save a considerable amount of money within a short period of time, due to the remarkable reduction of direct health costs associated with RVGE management. In fact, as the analysis shows, a universal vaccination against RV results in money-saving for the RHS already from the 2nd year (with a vaccination coverage of 50%). During the five year period, the active and free offer of the anti-RV vaccination would determine a total saving for RHS of about € 503.000. The cost-effectiveness analysis results showed a cost-saving ICER (incremental cost-effectiveness ratio) relevant to the RHS and equal to - €12.197/QALY.

CONCLUSION

In conclusion the adoption of a universal preventive strategy for all the infants in the Piedmont Region may contribute significantly towards the control of RVGE incidence, thus allowing a noteworthy saving of economic and social resources for both the RHS and the general public.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Department of Public Health, University of Turin, Turin, Italy. Electronic address: mariarosaria.gualano@unito.it.

Department of Public Health, University of Turin, Turin, Italy.

Department of Public Health, University of Turin, Turin, Italy.

Department of Public Health, University of Turin, Turin, Italy.

Department of Public Health, University of Turin, Turin, Italy.

Department of Public Health, University of Turin, Turin, Italy.

MeSH

Child, PreschoolCost-Benefit AnalysisFemaleHumansIncidenceInfantInfant, NewbornItalyMaleRotavirus InfectionsRotavirus VaccinesVaccinationVaccines, Attenuated

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30078657

Citation

Gualano, Maria R., et al. "Cost-effectiveness Estimates of Vaccination Against Rotavirus in Piedmont, Italy." Journal of Infection and Public Health, vol. 11, no. 6, 2018, pp. 867-872.

Gualano MR, Thomas R, Gili R, et al. Cost-effectiveness estimates of vaccination against rotavirus in Piedmont, Italy. J Infect Public Health. 2018;11(6):867-872.

Gualano, M. R., Thomas, R., Gili, R., Scaioli, G., Voglino, G., & Zotti, C. (2018). Cost-effectiveness estimates of vaccination against rotavirus in Piedmont, Italy. Journal of Infection and Public Health, 11(6), 867-872. https://doi.org/10.1016/j.jiph.2018.07.008

Gualano MR, et al. Cost-effectiveness Estimates of Vaccination Against Rotavirus in Piedmont, Italy. J Infect Public Health. 2018 Nov - Dec;11(6):867-872. PubMed PMID: 30078657.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Cost-effectiveness estimates of vaccination against rotavirus in Piedmont, Italy. AU - Gualano,Maria R, AU - Thomas,Robin, AU - Gili,Renata, AU - Scaioli,Giacomo, AU - Voglino,Gianluca, AU - Zotti,Carla, Y1 - 2018/08/02/ PY - 2018/04/24/received PY - 2018/06/29/revised PY - 2018/07/16/accepted PY - 2018/8/7/pubmed PY - 2018/12/18/medline PY - 2018/8/7/entrez KW - Burden of disease KW - Cost-effectiveness KW - Economic analysis KW - Rotavirus KW - Vaccine SP - 867 EP - 872 JF - Journal of infection and public health JO - J Infect Public Health VL - 11 IS - 6 N2 - BACKGROUND: Rotavirus-induced gastroenteritis (RVGE) represents the most frequent form of severe gastroenteritis in children. In such a scenario, the availability of an efficient anti-Rotavirus (anti-RV) vaccine represents an effective prevention tool able to prevent those complications mainly linked to the moderate-severe forms of this disease, which require hospital care. The aim of the present study is to estimate the cost effectiveness of universal routine infant RV vaccination program and its budget impact on the Regional Health Service (RHS) of Piedmont, Italy, in order to evaluate the opportunity of the implementation of a national anti-Rotavirus vaccination programme. METHODS: The researchers performed a cost-effectiveness analysis comparing costs and benefits of a Rotarix two-dose vaccination versus non vaccination and a budget impact analysis (BIA), complementary to the cost-effectiveness analysis. RESULTS: Our results show that the mass implementation of an anti-RV vaccination in Piedmont, in addition to the expected public health benefits, also allows the RHS to save a considerable amount of money within a short period of time, due to the remarkable reduction of direct health costs associated with RVGE management. In fact, as the analysis shows, a universal vaccination against RV results in money-saving for the RHS already from the 2nd year (with a vaccination coverage of 50%). During the five year period, the active and free offer of the anti-RV vaccination would determine a total saving for RHS of about € 503.000. The cost-effectiveness analysis results showed a cost-saving ICER (incremental cost-effectiveness ratio) relevant to the RHS and equal to - €12.197/QALY. CONCLUSION: In conclusion the adoption of a universal preventive strategy for all the infants in the Piedmont Region may contribute significantly towards the control of RVGE incidence, thus allowing a noteworthy saving of economic and social resources for both the RHS and the general public. SN - 1876-035X UR - https://www.unboundmedicine.com/medline/citation/30078657/Cost_effectiveness_estimates_of_vaccination_against_rotavirus_in_Piedmont_Italy_ DB - PRIME DP - Unbound Medicine ER -