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Increasing influenza vaccine uptake in children: A randomised controlled trial.
Vaccine. 2018 09 05; 36(37):5524-5535.V

Abstract

BACKGROUND

Influenza vaccine is not included in the Hong Kong Government's universal Childhood Immunisation Programme but eligible children can receive subsidised vaccine through the private sector using the Vaccination Subsidy Scheme (VSS). This study examined whether a simple intervention package can increase influenza vaccine uptake in Hong Kong children.

METHODS

Two study samples were enrolled: families of children who had participated in a previous knowledge, attitudes and practices study; and mother-infant pairs recruited from postnatal wards. Control groups received publicly available leaflets about VSS. Intervention groups additionally received: (1) a concise information sheet about influenza and its vaccine; (2) semi-completed forms to utilise the subsidy; (3) contacts of VSS clinics that did not charge above the subsidy; and (4) text message reminders for vaccination. Enrolled mothers were contacted when children were approximately 1 and 2 years old to determine influenza vaccination status of the families and their plan to vaccinate their children. Mothers' attitudes towards influenza vaccine were assessed at enrolment and at the end of the study.

RESULTS

A total of 833 eligible mother-infant pairs were enrolled from the two samples. The intervention package improved influenza vaccine uptake by 22% at one year and 25% at two years of age. Maternal influenza vaccine uptake in intervention group was higher during this two-year period in those who had never been previously vaccinated. Mothers' self-efficacy regarding the use of influenza vaccine in her child i.e. belief and confidence in her own ability to make a good decision, was also improved with the intervention.

CONCLUSIONS

A four-component intervention package could improve influenza vaccine uptake in Hong Kong children and their mothers during the first two years of life and depending on vaccine effectiveness could potentially reduce influenza-associated hospital admissions in children below 2 years old by 13-24%.

Authors+Show Affiliations

Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong Special Administrative Region.School of Nursing, The University of Hong Kong, Hong Kong Special Administrative Region.Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong Special Administrative Region.Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong Special Administrative Region.Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong Special Administrative Region. Electronic address: tony-nelson@cuhk.edu.hk.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30078745

Citation

Yeung, Karene Hoi Ting, et al. "Increasing Influenza Vaccine Uptake in Children: a Randomised Controlled Trial." Vaccine, vol. 36, no. 37, 2018, pp. 5524-5535.
Yeung KHT, Tarrant M, Chan KCC, et al. Increasing influenza vaccine uptake in children: A randomised controlled trial. Vaccine. 2018;36(37):5524-5535.
Yeung, K. H. T., Tarrant, M., Chan, K. C. C., Tam, W. H., & Nelson, E. A. S. (2018). Increasing influenza vaccine uptake in children: A randomised controlled trial. Vaccine, 36(37), 5524-5535. https://doi.org/10.1016/j.vaccine.2018.07.066
Yeung KHT, et al. Increasing Influenza Vaccine Uptake in Children: a Randomised Controlled Trial. Vaccine. 2018 09 5;36(37):5524-5535. PubMed PMID: 30078745.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increasing influenza vaccine uptake in children: A randomised controlled trial. AU - Yeung,Karene Hoi Ting, AU - Tarrant,Marie, AU - Chan,Kate Ching Ching, AU - Tam,Wing Hung, AU - Nelson,E Anthony S, Y1 - 2018/08/02/ PY - 2018/03/22/received PY - 2018/07/19/revised PY - 2018/07/24/accepted PY - 2018/8/7/pubmed PY - 2019/2/8/medline PY - 2018/8/7/entrez KW - Hong Kong KW - Influenza vaccine KW - Intervention KW - Paediatrics KW - Randomised controlled trial KW - Reminder SP - 5524 EP - 5535 JF - Vaccine JO - Vaccine VL - 36 IS - 37 N2 - BACKGROUND: Influenza vaccine is not included in the Hong Kong Government's universal Childhood Immunisation Programme but eligible children can receive subsidised vaccine through the private sector using the Vaccination Subsidy Scheme (VSS). This study examined whether a simple intervention package can increase influenza vaccine uptake in Hong Kong children. METHODS: Two study samples were enrolled: families of children who had participated in a previous knowledge, attitudes and practices study; and mother-infant pairs recruited from postnatal wards. Control groups received publicly available leaflets about VSS. Intervention groups additionally received: (1) a concise information sheet about influenza and its vaccine; (2) semi-completed forms to utilise the subsidy; (3) contacts of VSS clinics that did not charge above the subsidy; and (4) text message reminders for vaccination. Enrolled mothers were contacted when children were approximately 1 and 2 years old to determine influenza vaccination status of the families and their plan to vaccinate their children. Mothers' attitudes towards influenza vaccine were assessed at enrolment and at the end of the study. RESULTS: A total of 833 eligible mother-infant pairs were enrolled from the two samples. The intervention package improved influenza vaccine uptake by 22% at one year and 25% at two years of age. Maternal influenza vaccine uptake in intervention group was higher during this two-year period in those who had never been previously vaccinated. Mothers' self-efficacy regarding the use of influenza vaccine in her child i.e. belief and confidence in her own ability to make a good decision, was also improved with the intervention. CONCLUSIONS: A four-component intervention package could improve influenza vaccine uptake in Hong Kong children and their mothers during the first two years of life and depending on vaccine effectiveness could potentially reduce influenza-associated hospital admissions in children below 2 years old by 13-24%. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/30078745/Increasing_influenza_vaccine_uptake_in_children:_A_randomised_controlled_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(18)31075-2 DB - PRIME DP - Unbound Medicine ER -