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Evaluating Dorsal Root Ganglion Stimulation in a Prospective Dutch Cohort.
Neuromodulation 2019; 22(1):80-86N

Abstract

OBJECTIVES

Dorsal root ganglion (DRG) stimulation is a recent neuromodulation option that has delivered safe, effective pain relief for a number of etiologies. This prospective observational study was intended to establish the effectiveness of this treatment in a typical real-world clinical context.

MATERIALS AND METHODS

Participants with chronic, intractable pain of the trunk or lower limbs were recruited from multiple pain clinics in the Netherlands. Subjects were trialed and implanted with DRG stimulation systems. Pain, function, mood, and quality of life, ratings were collected through 12 months postimplant.

RESULTS

Of the 66 subjects enrolled, failed back surgery syndrome, peripheral nerve injury, and complex regional pain syndrome formed the largest etiologies. Permanent implants were placed in 86.2% subjects (56/65). After 12 months of treatment, average pain ratings in subjects' primary area of pain decreased from 8.0 cm at baseline to 4.1 cm, and 49% of subjects had ≥50% reduction in pain (visual analog scale). In addition, functional capacity was increased, and mood and quality of life improved. No confirmed lead migrations were observed, and there was a low rate of infection.

CONCLUSIONS

DRG stimulation significantly reduced the severity of subjects' pain and enabled participatory changes that improved quality of life through 12-months postimplant.

Authors+Show Affiliations

Erasmus University, Rotterdam, The Netherlands.Maastricht University Medical Centre, Maastricht, The Netherlands.St. Antonius Hospital, Nieuwegein, The Netherlands.Abbott Laboratories, Sunnyvale, CA, USA.Abbott Laboratories, Sunnyvale, CA, USA.

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

30079622

Citation

Huygen, Frank J P M., et al. "Evaluating Dorsal Root Ganglion Stimulation in a Prospective Dutch Cohort." Neuromodulation : Journal of the International Neuromodulation Society, vol. 22, no. 1, 2019, pp. 80-86.
Huygen FJPM, Liem L, Nijhuis H, et al. Evaluating Dorsal Root Ganglion Stimulation in a Prospective Dutch Cohort. Neuromodulation. 2019;22(1):80-86.
Huygen, F. J. P. M., Liem, L., Nijhuis, H., Cusack, W., & Kramer, J. (2019). Evaluating Dorsal Root Ganglion Stimulation in a Prospective Dutch Cohort. Neuromodulation : Journal of the International Neuromodulation Society, 22(1), pp. 80-86. doi:10.1111/ner.12798.
Huygen FJPM, et al. Evaluating Dorsal Root Ganglion Stimulation in a Prospective Dutch Cohort. Neuromodulation. 2019;22(1):80-86. PubMed PMID: 30079622.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluating Dorsal Root Ganglion Stimulation in a Prospective Dutch Cohort. AU - Huygen,Frank J P M, AU - Liem,Liong, AU - Nijhuis,Harold, AU - Cusack,William, AU - Kramer,Jeffery, Y1 - 2018/08/05/ PY - 2018/02/06/received PY - 2018/04/09/revised PY - 2018/04/29/accepted PY - 2018/8/7/pubmed PY - 2019/4/6/medline PY - 2018/8/7/entrez KW - dorsal root ganglion KW - function KW - neuropathic KW - pain KW - quality of life KW - spinal cord stimulation SP - 80 EP - 86 JF - Neuromodulation : journal of the International Neuromodulation Society JO - Neuromodulation VL - 22 IS - 1 N2 - OBJECTIVES: Dorsal root ganglion (DRG) stimulation is a recent neuromodulation option that has delivered safe, effective pain relief for a number of etiologies. This prospective observational study was intended to establish the effectiveness of this treatment in a typical real-world clinical context. MATERIALS AND METHODS: Participants with chronic, intractable pain of the trunk or lower limbs were recruited from multiple pain clinics in the Netherlands. Subjects were trialed and implanted with DRG stimulation systems. Pain, function, mood, and quality of life, ratings were collected through 12 months postimplant. RESULTS: Of the 66 subjects enrolled, failed back surgery syndrome, peripheral nerve injury, and complex regional pain syndrome formed the largest etiologies. Permanent implants were placed in 86.2% subjects (56/65). After 12 months of treatment, average pain ratings in subjects' primary area of pain decreased from 8.0 cm at baseline to 4.1 cm, and 49% of subjects had ≥50% reduction in pain (visual analog scale). In addition, functional capacity was increased, and mood and quality of life improved. No confirmed lead migrations were observed, and there was a low rate of infection. CONCLUSIONS: DRG stimulation significantly reduced the severity of subjects' pain and enabled participatory changes that improved quality of life through 12-months postimplant. SN - 1525-1403 UR - https://www.unboundmedicine.com/medline/citation/30079622/Evaluating_Dorsal_Root_Ganglion_Stimulation_in_a_Prospective_Dutch_Cohort_ L2 - https://doi.org/10.1111/ner.12798 DB - PRIME DP - Unbound Medicine ER -