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Abnormal Human Sperm Parameters Contribute to Sperm DNA Fragmentation in Men with Varicocele.
World J Mens Health 2018; 36(3):239-247WJ

Abstract

PURPOSE

This study was performed to evaluate and compare threshold sperm parameters and sperm DNA fragmentation index (DFI), and further analyzed whether sperm DFI could be predicted from sperm parameters in men with varicocele.

MATERIALS AND METHODS

A total of 157 semen samples underwent both semen analysis and sperm DNA fragmentation (SDF) testing in men with varicocele. Sperm parameters were assessed using the World Health Organization guidelines. SDF testing was performed using the Halosperm kit. Sperm parameters and sperm DFI results were compared.

RESULTS

The overall sperm parameter results and sperm DFI showed normal values; however, the morphology value was at the lower limit of normal. High sperm DFI was associated with significantly lower motility and viability (p<0.001, respectively). Sperm motility and morphology were significantly higher in the higher sperm count group compared to the lower sperm count group (p<0.05), while sperm DFI was higher in the lower sperm count group (p<0.05). Sperm count and viability and sperm DFI were significantly associated with the quality of sperm motility (p<0.001). Sperm motility and sperm DFI were significantly different (p<0.001) between normal and abnormal sperm viability groups. Between normal and abnormal sperm morphology groups, sperm count, motility, and sperm DFI showed significant differences (p<0.001).

CONCLUSIONS

In this study, a correlation between SDF and sperm parameters was confirmed in men with varicocele. SDF may be contributing factors to sperm motility, viability, and morphology. Abnormal sperm count, motility, and viability showed high sperm DFI. Therefore, lower sperm parameters were indicative of increasing SDF in men with varicocele.

Authors+Show Affiliations

Laboratory of Reproductive Medicine, Cheil General Hospital and Women's Healthcare Center, Dankook University College of Medicine, Seoul, Korea.Laboratory of Reproductive Medicine, Cheil General Hospital and Women's Healthcare Center, Dankook University College of Medicine, Seoul, Korea. Division of Developmental Biology and Physiology, School of Biosciences and Chemistry, Sungshin Women's University, Seoul, Korea.Laboratory of Reproductive Medicine, Cheil General Hospital and Women's Healthcare Center, Dankook University College of Medicine, Seoul, Korea.Department of Urology, Cheil General Hospital and Women's Healthcare Center, Dankook University College of Medicine, Seoul, Korea.Department of Urology, Cheil General Hospital and Women's Healthcare Center, Dankook University College of Medicine, Seoul, Korea.Department of Urology, Cheil General Hospital and Women's Healthcare Center, Dankook University College of Medicine, Seoul, Korea. jtandro@cgh.co.kr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30079641

Citation

Park, Yong Seog, et al. "Abnormal Human Sperm Parameters Contribute to Sperm DNA Fragmentation in Men With Varicocele." The World Journal of Men's Health, vol. 36, no. 3, 2018, pp. 239-247.
Park YS, Lee SH, Choi HW, et al. Abnormal Human Sperm Parameters Contribute to Sperm DNA Fragmentation in Men with Varicocele. World J Mens Health. 2018;36(3):239-247.
Park, Y. S., Lee, S. H., Choi, H. W., Lee, H. S., Lee, J. S., & Seo, J. T. (2018). Abnormal Human Sperm Parameters Contribute to Sperm DNA Fragmentation in Men with Varicocele. The World Journal of Men's Health, 36(3), pp. 239-247. doi:10.5534/wjmh.180014.
Park YS, et al. Abnormal Human Sperm Parameters Contribute to Sperm DNA Fragmentation in Men With Varicocele. World J Mens Health. 2018;36(3):239-247. PubMed PMID: 30079641.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abnormal Human Sperm Parameters Contribute to Sperm DNA Fragmentation in Men with Varicocele. AU - Park,Yong Seog, AU - Lee,Sun Hee, AU - Choi,Hye Won, AU - Lee,Hyo Serk, AU - Lee,Joong Shik, AU - Seo,Ju Tae, Y1 - 2018/07/30/ PY - 2018/02/26/received PY - 2018/05/16/revised PY - 2018/05/23/accepted PY - 2018/8/7/pubmed PY - 2018/8/7/medline PY - 2018/8/7/entrez KW - DNA fragmentation KW - Infertility KW - Semen analysis KW - Sperm KW - Spermatogenesis KW - Varicocele SP - 239 EP - 247 JF - The world journal of men's health JO - World J Mens Health VL - 36 IS - 3 N2 - PURPOSE: This study was performed to evaluate and compare threshold sperm parameters and sperm DNA fragmentation index (DFI), and further analyzed whether sperm DFI could be predicted from sperm parameters in men with varicocele. MATERIALS AND METHODS: A total of 157 semen samples underwent both semen analysis and sperm DNA fragmentation (SDF) testing in men with varicocele. Sperm parameters were assessed using the World Health Organization guidelines. SDF testing was performed using the Halosperm kit. Sperm parameters and sperm DFI results were compared. RESULTS: The overall sperm parameter results and sperm DFI showed normal values; however, the morphology value was at the lower limit of normal. High sperm DFI was associated with significantly lower motility and viability (p<0.001, respectively). Sperm motility and morphology were significantly higher in the higher sperm count group compared to the lower sperm count group (p<0.05), while sperm DFI was higher in the lower sperm count group (p<0.05). Sperm count and viability and sperm DFI were significantly associated with the quality of sperm motility (p<0.001). Sperm motility and sperm DFI were significantly different (p<0.001) between normal and abnormal sperm viability groups. Between normal and abnormal sperm morphology groups, sperm count, motility, and sperm DFI showed significant differences (p<0.001). CONCLUSIONS: In this study, a correlation between SDF and sperm parameters was confirmed in men with varicocele. SDF may be contributing factors to sperm motility, viability, and morphology. Abnormal sperm count, motility, and viability showed high sperm DFI. Therefore, lower sperm parameters were indicative of increasing SDF in men with varicocele. SN - 2287-4208 UR - https://www.unboundmedicine.com/medline/citation/30079641/Abnormal_Human_Sperm_Parameters_Contribute_to_Sperm_DNA_Fragmentation_in_Men_with_Varicocele_ L2 - https://wjmh.org/DOIx.php?id=10.5534/wjmh.180014 DB - PRIME DP - Unbound Medicine ER -