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Milk thistle (Silybum marianum): A concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases.
Phytother Res 2018; 32(11):2202-2213PR

Abstract

Milk thistle (MT; Silybum marianum), a member of the Asteraceae family, is a therapeutic herb with a 2,000-year history of use. MT fruits contain a mixture of flavonolignans collectively known as silymarin, being silybin (also named silibinin) the main component. This article reviews the chemistry of MT, the pharmacokinetics and bioavailability, the pharmacologically relevant actions for liver diseases (e.g., anti-inflammatory, immunomodulating, antifibrotic, antioxidant, and liver-regenerating properties) as well as the clinical potential in patients with alcoholic liver disease, nonalcoholic fatty liver disease, viral hepatitis, drug-induced liver injury, and mushroom poisoning. Overall, literature data suggest that, despite encouraging preclinical data, further well-designed randomized clinical trials are needed to fully substantiate the real value of MT preparations in liver diseases.

Authors+Show Affiliations

Department of Health Sciences, University Magna Graecia, Catanzaro, Italy.Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy.Department of Pharmacy, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy.Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy.Department of Agricultural Sciences, University of Naples Federico II, Naples, Italy.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30080294

Citation

Abenavoli, Ludovico, et al. "Milk Thistle (Silybum Marianum): a Concise Overview On Its Chemistry, Pharmacological, and Nutraceutical Uses in Liver Diseases." Phytotherapy Research : PTR, vol. 32, no. 11, 2018, pp. 2202-2213.
Abenavoli L, Izzo AA, Milić N, et al. Milk thistle (Silybum marianum): A concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases. Phytother Res. 2018;32(11):2202-2213.
Abenavoli, L., Izzo, A. A., Milić, N., Cicala, C., Santini, A., & Capasso, R. (2018). Milk thistle (Silybum marianum): A concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases. Phytotherapy Research : PTR, 32(11), pp. 2202-2213. doi:10.1002/ptr.6171.
Abenavoli L, et al. Milk Thistle (Silybum Marianum): a Concise Overview On Its Chemistry, Pharmacological, and Nutraceutical Uses in Liver Diseases. Phytother Res. 2018;32(11):2202-2213. PubMed PMID: 30080294.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Milk thistle (Silybum marianum): A concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases. AU - Abenavoli,Ludovico, AU - Izzo,Angelo A, AU - Milić,Natasa, AU - Cicala,Carla, AU - Santini,Antonello, AU - Capasso,Raffaele, Y1 - 2018/08/06/ PY - 2018/03/30/received PY - 2018/07/06/revised PY - 2018/07/09/accepted PY - 2018/8/7/pubmed PY - 2018/11/22/medline PY - 2018/8/7/entrez KW - liver fibrosis KW - oxidative stress KW - silybin KW - silymarin SP - 2202 EP - 2213 JF - Phytotherapy research : PTR JO - Phytother Res VL - 32 IS - 11 N2 - Milk thistle (MT; Silybum marianum), a member of the Asteraceae family, is a therapeutic herb with a 2,000-year history of use. MT fruits contain a mixture of flavonolignans collectively known as silymarin, being silybin (also named silibinin) the main component. This article reviews the chemistry of MT, the pharmacokinetics and bioavailability, the pharmacologically relevant actions for liver diseases (e.g., anti-inflammatory, immunomodulating, antifibrotic, antioxidant, and liver-regenerating properties) as well as the clinical potential in patients with alcoholic liver disease, nonalcoholic fatty liver disease, viral hepatitis, drug-induced liver injury, and mushroom poisoning. Overall, literature data suggest that, despite encouraging preclinical data, further well-designed randomized clinical trials are needed to fully substantiate the real value of MT preparations in liver diseases. SN - 1099-1573 UR - https://www.unboundmedicine.com/medline/citation/30080294/Milk_thistle__Silybum_marianum_:_A_concise_overview_on_its_chemistry_pharmacological_and_nutraceutical_uses_in_liver_diseases_ L2 - https://doi.org/10.1002/ptr.6171 DB - PRIME DP - Unbound Medicine ER -