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Alterations in plasma acylcarnitine and amino acid profiles may indicate poor nutrition during the suckling period due to maternal intake of an unbalanced diet and may predict later metabolic dysfunction.
FASEB J 2019; 33(1):796-807FJ

Abstract

Plasma profiles of acylcarnitines (ACs) and amino acids (AAs) may have interest as potential biomarkers. Here we analyzed plasma AC and AA profiles in 2 rat models with different metabolic programming outcomes: offspring of dams fed a cafeteria diet during lactation (O-CAF, with a thin-outside-fat-inside phenotype) and the offspring of dams with diet-induced obesity subjected to dietary normalization before gestation [offspring of postcafeteria dams (O-PCaf), nonaltered phenotype]. The purpose was to identify early variables that might indicate a propensity for a dysmetabolic state. O-CAF rats presented higher circulating levels of most of the lipid-derived ACs and higher hepatic expression of genes related to fatty acid oxidation (Ppara and Cpt1a) than controls [offspring of control dams (O-C)]. They also exhibited an altered plasma AA profile. These differences were not observed in O-PCaf animals. A partial least squares-discriminant analysis score plot of the metabolomics data showed a clear separation between O-CAF and O-C animals. The long-chain ACs (C18, C18:1, C18:2, C16:1, and C16DC) and the AAs glycine, alanine, isoleucine, serine, and proline are the variables mainly influencing this separation. In summary, we have identified a cluster of ACs and AAs whose alterations may indicate poor nutrition during lactation due to maternal unbalanced diet intake and predict the later dysmetabolic phenotype observed in the offspring.-Pomar, C. A., Kuda, O., Kopecky, J., Rombaldova, M., Castro, H., Picó, C., Sánchez, J., Palou, A. Alterations in plasma acylcarnitine and amino acid profiles may indicate poor nutrition during the suckling period due to maternal intake of an unbalanced diet and may predict later metabolic dysfunction.

Authors+Show Affiliations

Laboratory of Molecular Biology, Nutrition, and Biotechnology (Nutrigenomics and Obesity), Palma de Mallorca, Spain. Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBEROBN), University of the Balearic Islands, Palma de Mallorca, Spain.Department of Adipose Tissue Biology, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.Department of Adipose Tissue Biology, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.Department of Adipose Tissue Biology, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.Laboratory of Molecular Biology, Nutrition, and Biotechnology (Nutrigenomics and Obesity), Palma de Mallorca, Spain. Facultad de Salud Pública y Nutrición, Universidad Autónoma de Nuevo León, Nuevo León, Mexico; and.Laboratory of Molecular Biology, Nutrition, and Biotechnology (Nutrigenomics and Obesity), Palma de Mallorca, Spain. Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBEROBN), University of the Balearic Islands, Palma de Mallorca, Spain. Instituto de Investigación Sanitaria Illes Balears, Palma de Mallorca, Spain.Laboratory of Molecular Biology, Nutrition, and Biotechnology (Nutrigenomics and Obesity), Palma de Mallorca, Spain. Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBEROBN), University of the Balearic Islands, Palma de Mallorca, Spain. Instituto de Investigación Sanitaria Illes Balears, Palma de Mallorca, Spain.Laboratory of Molecular Biology, Nutrition, and Biotechnology (Nutrigenomics and Obesity), Palma de Mallorca, Spain. Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBEROBN), University of the Balearic Islands, Palma de Mallorca, Spain. Instituto de Investigación Sanitaria Illes Balears, Palma de Mallorca, Spain.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30080446

Citation

Pomar, Catalina A., et al. "Alterations in Plasma Acylcarnitine and Amino Acid Profiles May Indicate Poor Nutrition During the Suckling Period Due to Maternal Intake of an Unbalanced Diet and May Predict Later Metabolic Dysfunction." FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology, vol. 33, no. 1, 2019, pp. 796-807.
Pomar CA, Kuda O, Kopecky J, et al. Alterations in plasma acylcarnitine and amino acid profiles may indicate poor nutrition during the suckling period due to maternal intake of an unbalanced diet and may predict later metabolic dysfunction. FASEB J. 2019;33(1):796-807.
Pomar, C. A., Kuda, O., Kopecky, J., Rombaldova, M., Castro, H., Picó, C., ... Palou, A. (2019). Alterations in plasma acylcarnitine and amino acid profiles may indicate poor nutrition during the suckling period due to maternal intake of an unbalanced diet and may predict later metabolic dysfunction. FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology, 33(1), pp. 796-807. doi:10.1096/fj.201800327RR.
Pomar CA, et al. Alterations in Plasma Acylcarnitine and Amino Acid Profiles May Indicate Poor Nutrition During the Suckling Period Due to Maternal Intake of an Unbalanced Diet and May Predict Later Metabolic Dysfunction. FASEB J. 2019;33(1):796-807. PubMed PMID: 30080446.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alterations in plasma acylcarnitine and amino acid profiles may indicate poor nutrition during the suckling period due to maternal intake of an unbalanced diet and may predict later metabolic dysfunction. AU - Pomar,Catalina A, AU - Kuda,Ondrej, AU - Kopecky,Jan, AU - Rombaldova,Martina, AU - Castro,Heriberto, AU - Picó,Catalina, AU - Sánchez,Juana, AU - Palou,Andreu, Y1 - 2018/08/06/ PY - 2018/8/7/pubmed PY - 2019/8/20/medline PY - 2018/8/7/entrez KW - cafeteria diet KW - early biomarkers KW - perinatal nutrition KW - postcafeteria SP - 796 EP - 807 JF - FASEB journal : official publication of the Federation of American Societies for Experimental Biology JO - FASEB J. VL - 33 IS - 1 N2 - Plasma profiles of acylcarnitines (ACs) and amino acids (AAs) may have interest as potential biomarkers. Here we analyzed plasma AC and AA profiles in 2 rat models with different metabolic programming outcomes: offspring of dams fed a cafeteria diet during lactation (O-CAF, with a thin-outside-fat-inside phenotype) and the offspring of dams with diet-induced obesity subjected to dietary normalization before gestation [offspring of postcafeteria dams (O-PCaf), nonaltered phenotype]. The purpose was to identify early variables that might indicate a propensity for a dysmetabolic state. O-CAF rats presented higher circulating levels of most of the lipid-derived ACs and higher hepatic expression of genes related to fatty acid oxidation (Ppara and Cpt1a) than controls [offspring of control dams (O-C)]. They also exhibited an altered plasma AA profile. These differences were not observed in O-PCaf animals. A partial least squares-discriminant analysis score plot of the metabolomics data showed a clear separation between O-CAF and O-C animals. The long-chain ACs (C18, C18:1, C18:2, C16:1, and C16DC) and the AAs glycine, alanine, isoleucine, serine, and proline are the variables mainly influencing this separation. In summary, we have identified a cluster of ACs and AAs whose alterations may indicate poor nutrition during lactation due to maternal unbalanced diet intake and predict the later dysmetabolic phenotype observed in the offspring.-Pomar, C. A., Kuda, O., Kopecky, J., Rombaldova, M., Castro, H., Picó, C., Sánchez, J., Palou, A. Alterations in plasma acylcarnitine and amino acid profiles may indicate poor nutrition during the suckling period due to maternal intake of an unbalanced diet and may predict later metabolic dysfunction. SN - 1530-6860 UR - https://www.unboundmedicine.com/medline/citation/30080446/Alterations_in_plasma_acylcarnitine_and_amino_acid_profiles_may_indicate_poor_nutrition_during_the_suckling_period_due_to_maternal_intake_of_an_unbalanced_diet_and_may_predict_later_metabolic_dysfunction_ L2 - http://www.fasebj.org/doi/full/10.1096/fj.201800327RR?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -