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Oxidative stress in opium users after using lead-adulterated opium: The role of genetic polymorphism.
Food Chem Toxicol 2018; 120:571-577FC

Abstract

Use of lead-adulterated opium has become one of the major sources of lead poisoning in Iran. This study was designed to assess clinical effects and oxidative stress and its association with GSTM1, GSTT1, NQO1, and ALAD genes polymorphisms and blood lead level (BLL) in lead-adulterated opium users. The oxidative stress status in 192 opium users with lead poisoning symptoms measured and compared with 102 healthy individuals. Gluthatione S-transferase (GST)-M1 and -T1 genes deletion, NQO1 rs1800566, and δ-aminolevulinic acid dehydratase (ALAD) rs1800435 polymorphisms were determined using PCR and PCR-RFLP. The relation between the polymorphisms, BLL, and oxidative stress parameters were analysed using multivariate linear regressions. The common symptoms of lead toxicity were gastrointestinal and neurologic complications. Oxidative stress was significantly higher in opium addicts and lipid peroxidation significantly correlated with BLL. There was significant association between ALAD rs1800435 and BLL, and the BLL was significantly lower in the patients with ALAD 1-2 genotype. Use of lead-adulterated opium causes high frequency of lead toxicity symptoms, hematological and biochemical abnormalities, and oxidative stress which are associated with BLL. Route of opioid use and the polymorphism of rs1800435 in ALAD gene are the major determinants of BLL in lead-adulterated opium users.

Authors+Show Affiliations

Department of Pharmacology, School of Veterinary, Shiraz University, Iran; Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran. Electronic address: drsaeideh@yahoo.com.Department of Pharmacology, School of Veterinary, Shiraz University, Iran. Electronic address: mfazeli@shirazu.ac.ir.Gastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran; Department of Toxicology & Pharmacology, School of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran. Electronic address: zoghabian@kmu.ac.ir.Department of Toxicology & Pharmacology, School of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran; Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran. Electronic address: leyla.pourgholi5@gmail.com.Department of Toxicology & Pharmacology, School of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran; Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran. Electronic address: alimandegary@kmu.ac.ir.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30081045

Citation

Shojaeepour, Saeedeh, et al. "Oxidative Stress in Opium Users After Using Lead-adulterated Opium: the Role of Genetic Polymorphism." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 120, 2018, pp. 571-577.
Shojaeepour S, Fazeli M, Oghabian Z, et al. Oxidative stress in opium users after using lead-adulterated opium: The role of genetic polymorphism. Food Chem Toxicol. 2018;120:571-577.
Shojaeepour, S., Fazeli, M., Oghabian, Z., Pourgholi, L., & Mandegary, A. (2018). Oxidative stress in opium users after using lead-adulterated opium: The role of genetic polymorphism. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 120, pp. 571-577. doi:10.1016/j.fct.2018.07.061.
Shojaeepour S, et al. Oxidative Stress in Opium Users After Using Lead-adulterated Opium: the Role of Genetic Polymorphism. Food Chem Toxicol. 2018;120:571-577. PubMed PMID: 30081045.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative stress in opium users after using lead-adulterated opium: The role of genetic polymorphism. AU - Shojaeepour,Saeedeh, AU - Fazeli,Mehdi, AU - Oghabian,Zohreh, AU - Pourgholi,Leyla, AU - Mandegary,Ali, Y1 - 2018/08/03/ PY - 2017/11/28/received PY - 2018/05/15/revised PY - 2018/07/31/accepted PY - 2018/8/7/pubmed PY - 2018/12/12/medline PY - 2018/8/7/entrez KW - ALAD KW - GST KW - Genetic polymorphism KW - Lead poisoning KW - NQO1 KW - Opium KW - Oxidative stress SP - 571 EP - 577 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem. Toxicol. VL - 120 N2 - Use of lead-adulterated opium has become one of the major sources of lead poisoning in Iran. This study was designed to assess clinical effects and oxidative stress and its association with GSTM1, GSTT1, NQO1, and ALAD genes polymorphisms and blood lead level (BLL) in lead-adulterated opium users. The oxidative stress status in 192 opium users with lead poisoning symptoms measured and compared with 102 healthy individuals. Gluthatione S-transferase (GST)-M1 and -T1 genes deletion, NQO1 rs1800566, and δ-aminolevulinic acid dehydratase (ALAD) rs1800435 polymorphisms were determined using PCR and PCR-RFLP. The relation between the polymorphisms, BLL, and oxidative stress parameters were analysed using multivariate linear regressions. The common symptoms of lead toxicity were gastrointestinal and neurologic complications. Oxidative stress was significantly higher in opium addicts and lipid peroxidation significantly correlated with BLL. There was significant association between ALAD rs1800435 and BLL, and the BLL was significantly lower in the patients with ALAD 1-2 genotype. Use of lead-adulterated opium causes high frequency of lead toxicity symptoms, hematological and biochemical abnormalities, and oxidative stress which are associated with BLL. Route of opioid use and the polymorphism of rs1800435 in ALAD gene are the major determinants of BLL in lead-adulterated opium users. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/30081045/Oxidative_stress_in_opium_users_after_using_lead_adulterated_opium:_The_role_of_genetic_polymorphism_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(18)30506-4 DB - PRIME DP - Unbound Medicine ER -