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[Piracetam correction of deficient GABA-ergic inhibition due to early postnatal exposure to cycloheximide].
Biull Eksp Biol Med. 1986 Apr; 101(4):447-9.BE

Abstract

Cycloheximide, administered to 7-day-old rats, caused the delay of CNS activity changes in grown-up rats. The animals showed impaired memory function, expressed in the decrease of habituation in the "open field" test, and the alteration of passive avoidance reflex. The increased number of intersignal reactions due to hypermotility was found during elaboration of avoidance reflex. The analysis of evoked potential recovery revealed the deficiency of GABA-ergic inhibition in the neocortex. Piracetam was shown to prevent completely behavioural disturbances and deficiency of GABA-ergic processes in grown-up animals.

Authors

Burov IuV
No affiliation info available
Ostrovskaia RU
No affiliation info available
Smol'nikova NM
No affiliation info available
Trofimov SS
No affiliation info available
Molodavkin GM
No affiliation info available

MeSH

AnimalsBody WeightConditioning, ClassicalCycloheximideEscape ReactionIsotonic SolutionsLearningMemoryMotor ActivityNeural InhibitionPiracetamPyrrolidinonesRatsReceptors, GABA-ASodium ChlorideTime Factors

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

rus

PubMed ID

3008881

Citation

Burov, Iu V., et al. "[Piracetam Correction of Deficient GABA-ergic Inhibition Due to Early Postnatal Exposure to Cycloheximide]." Biulleten' Eksperimental'noi Biologii I Meditsiny, vol. 101, no. 4, 1986, pp. 447-9.
Burov IuV, Ostrovskaia RU, Smol'nikova NM, et al. [Piracetam correction of deficient GABA-ergic inhibition due to early postnatal exposure to cycloheximide]. Biull Eksp Biol Med. 1986;101(4):447-9.
Burov, I. u. V., Ostrovskaia, R. U., Smol'nikova, N. M., Trofimov, S. S., & Molodavkin, G. M. (1986). [Piracetam correction of deficient GABA-ergic inhibition due to early postnatal exposure to cycloheximide]. Biulleten' Eksperimental'noi Biologii I Meditsiny, 101(4), 447-9.
Burov IuV, et al. [Piracetam Correction of Deficient GABA-ergic Inhibition Due to Early Postnatal Exposure to Cycloheximide]. Biull Eksp Biol Med. 1986;101(4):447-9. PubMed PMID: 3008881.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Piracetam correction of deficient GABA-ergic inhibition due to early postnatal exposure to cycloheximide]. AU - Burov,Iu V, AU - Ostrovskaia,R U, AU - Smol'nikova,N M, AU - Trofimov,S S, AU - Molodavkin,G M, PY - 1986/4/1/pubmed PY - 1986/4/1/medline PY - 1986/4/1/entrez SP - 447 EP - 9 JF - Biulleten' eksperimental'noi biologii i meditsiny JO - Biull Eksp Biol Med VL - 101 IS - 4 N2 - Cycloheximide, administered to 7-day-old rats, caused the delay of CNS activity changes in grown-up rats. The animals showed impaired memory function, expressed in the decrease of habituation in the "open field" test, and the alteration of passive avoidance reflex. The increased number of intersignal reactions due to hypermotility was found during elaboration of avoidance reflex. The analysis of evoked potential recovery revealed the deficiency of GABA-ergic inhibition in the neocortex. Piracetam was shown to prevent completely behavioural disturbances and deficiency of GABA-ergic processes in grown-up animals. SN - 0365-9615 UR - https://www.unboundmedicine.com/medline/citation/3008881/[Piracetam_correction_of_deficient_GABA_ergic_inhibition_due_to_early_postnatal_exposure_to_cycloheximide]_ DB - PRIME DP - Unbound Medicine ER -