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Fatigue is not associated with vitamin D deficiency in inflammatory bowel disease patients.
World J Gastroenterol 2018; 24(29):3293-3301WJ

Abstract

AIM

To investigate if vitamin D deficiency is associated with fatigue in patients with inflammatory bowel disease (IBD).

METHODS

IBD patients were recruited from nine hospitals in the southeastern and western regions of Norway to participate in a multicenter cross-sectional study lasting from March 2013 to April 2014. Data were collected by interviews, from medical records and laboratory tests. The Fatigue Questionnaire (FQ) was used to measure fatigue. Linear and logistic regression models were applied to explore the possible association between vitamin D deficiency and total fatigue scores and chronic fatigue, respectively. The analyses were adjusted for age, gender, disease activity, depressive symptoms and sleep disturbance.

RESULTS

In total, 405 patients were included in the analyses, of which 227 (56%) had Crohn's disease (CD) and 178 (44%) had ulcerative colitis (UC). Vitamin D deficiency (< 50 nmol/L) was present in half (203/405) of the patients. Chronic fatigue was reported by 116 (29%) of all included patients with substantial fatigue reported by 194 (48%). Vitamin D levels were neither associated with total fatigue nor with chronic fatigue. Higher total fatigue scores and chronic fatigue were both associated with increased disease activity scores in patients with UC and CD, but not with increased CRP or fecal calprotectin. In UC patients, female gender was associated with fatigue in the univariate analysis, but no such difference was found when adjusted for elevated disease activity scores. Sleep disturbance and more depressive symptoms were associated with total fatigue scores in both UC and CD patients, but with chronic fatigue only in CD patients.

CONCLUSION

In this study, no significant association between fatigue and vitamin D deficiency in IBD patients was revealed.

Authors+Show Affiliations

Department of Medicine, Vestre Viken Bærum Hospital, Gjettum 1346, Norway.Department of Gastroenterology, Oslo University Hospital, Oslo 0424, Norway.Department of Gastroenterology, Akershus University Hospital, Lørenskog 1478, Norway.Faculty of Health Sciences, Oslo Metropolitan University, Oslo 0130, Norway.Department of Gastroenterology, Stavanger University Hospital, Stavanger 4068, Norway.Department of Medicine, Ålesund Hospital Trust, Ålesund 6026, Norway.Department of Gastroenterology, Telemark Hospital Trust, Skien 3710, Norway.Department of Medicine, Innlandet Hospital Trust, Gjøvik 2819, Norway.Department of Research and Development, Vestfold Hospital Trust, Tønsberg 3103, Norway.Department of Gastroenterology, Oslo University Hospital, Oslo 0424, Norway.Department of Gastroenterology, Østfold Hospital Kalnes, Grålum 1714, Norway.

Pub Type(s)

Journal Article
Multicenter Study
Observational Study

Language

eng

PubMed ID

30090009

Citation

Frigstad, Svein Oskar, et al. "Fatigue Is Not Associated With Vitamin D Deficiency in Inflammatory Bowel Disease Patients." World Journal of Gastroenterology, vol. 24, no. 29, 2018, pp. 3293-3301.
Frigstad SO, Høivik ML, Jahnsen J, et al. Fatigue is not associated with vitamin D deficiency in inflammatory bowel disease patients. World J Gastroenterol. 2018;24(29):3293-3301.
Frigstad, S. O., Høivik, M. L., Jahnsen, J., Cvancarova, M., Grimstad, T., Berset, I. P., ... Jelsness-Jørgensen, L. P. (2018). Fatigue is not associated with vitamin D deficiency in inflammatory bowel disease patients. World Journal of Gastroenterology, 24(29), pp. 3293-3301. doi:10.3748/wjg.v24.i29.3293.
Frigstad SO, et al. Fatigue Is Not Associated With Vitamin D Deficiency in Inflammatory Bowel Disease Patients. World J Gastroenterol. 2018 Aug 7;24(29):3293-3301. PubMed PMID: 30090009.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fatigue is not associated with vitamin D deficiency in inflammatory bowel disease patients. AU - Frigstad,Svein Oskar, AU - Høivik,Marte Lie, AU - Jahnsen,Jørgen, AU - Cvancarova,Milada, AU - Grimstad,Tore, AU - Berset,Ingrid Prytz, AU - Huppertz-Hauss,Gert, AU - Hovde,Øistein, AU - Bernklev,Tomm, AU - Moum,Bjørn, AU - Jelsness-Jørgensen,Lars-Petter, PY - 2018/04/04/received PY - 2018/06/17/revised PY - 2018/06/27/accepted PY - 2018/8/10/entrez PY - 2018/8/10/pubmed PY - 2018/11/10/medline KW - Chronic fatigue KW - Crohn’s disease KW - Fatigue KW - Inflammatory bowel disease KW - Ulcerative colitis KW - Vitamin D deficiency SP - 3293 EP - 3301 JF - World journal of gastroenterology JO - World J. Gastroenterol. VL - 24 IS - 29 N2 - AIM: To investigate if vitamin D deficiency is associated with fatigue in patients with inflammatory bowel disease (IBD). METHODS: IBD patients were recruited from nine hospitals in the southeastern and western regions of Norway to participate in a multicenter cross-sectional study lasting from March 2013 to April 2014. Data were collected by interviews, from medical records and laboratory tests. The Fatigue Questionnaire (FQ) was used to measure fatigue. Linear and logistic regression models were applied to explore the possible association between vitamin D deficiency and total fatigue scores and chronic fatigue, respectively. The analyses were adjusted for age, gender, disease activity, depressive symptoms and sleep disturbance. RESULTS: In total, 405 patients were included in the analyses, of which 227 (56%) had Crohn's disease (CD) and 178 (44%) had ulcerative colitis (UC). Vitamin D deficiency (< 50 nmol/L) was present in half (203/405) of the patients. Chronic fatigue was reported by 116 (29%) of all included patients with substantial fatigue reported by 194 (48%). Vitamin D levels were neither associated with total fatigue nor with chronic fatigue. Higher total fatigue scores and chronic fatigue were both associated with increased disease activity scores in patients with UC and CD, but not with increased CRP or fecal calprotectin. In UC patients, female gender was associated with fatigue in the univariate analysis, but no such difference was found when adjusted for elevated disease activity scores. Sleep disturbance and more depressive symptoms were associated with total fatigue scores in both UC and CD patients, but with chronic fatigue only in CD patients. CONCLUSION: In this study, no significant association between fatigue and vitamin D deficiency in IBD patients was revealed. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/30090009/Fatigue_is_not_associated_with_vitamin_D_deficiency_in_inflammatory_bowel_disease_patients_ L2 - http://www.wjgnet.com/1007-9327/full/v24/i29/3293.htm DB - PRIME DP - Unbound Medicine ER -