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Hydrogels for biomedical applications from glycol chitosan and PEG diglycidyl ether exhibit pro-angiogenic and antibacterial activity.
Carbohydr Polym 2018; 198:124-130CP

Abstract

We aimed at producing a hydrogel from a chitosan (CS) derivative soluble in physiological conditions to avoid any purification step thus allowing to use the materials also as an in-situ forming material. So, we crosslinked glycol chitosan (GCS) with poly(ethylene glycol) diglycidyl ether (PEGDE) in water at 37 °C. The scaffolds, referred as GCS-PEG, were specifically designed to be used as wound dressing materials as such (after crosslinking) or as in-situ forming materials. Different amounts of PEGDE were tested. The obtained scaffolds showed macroscopic pores and a tailorable swelling in water by controlling the crosslinking degree. Moreover, GCS-PEG scaffolds displayed a significant antimicrobial activity against Staphylococcus aureus. In-vivo study using the chick embryo choriallantoic membrane resulted in a highly pronounced pro-angiogenic activity suggesting important tissue regeneration properties. Moreover, the employed materials are commercially available, no organic solvents are required and the scaling up is quite predictable.

Authors+Show Affiliations

Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.Department of Pharmacy-Drug Sciences, University of Bari "Aldo Moro", Via Orabona 4, 70125 Bari, Italy.Department of Pharmacy-Drug Sciences, University of Bari "Aldo Moro", Via Orabona 4, 70125 Bari, Italy.CNR-IFN Bari, Via Amendola 173, Bari, Italy.Department of Basic Medical Sciences, Neurosciences, and Sensory Organs, University of Bari Medical School, Piazza Giulio Cesare 11, 70100 Bari, Italy.Department of Pharmacy-Drug Sciences, University of Bari "Aldo Moro", Via Orabona 4, 70125 Bari, Italy.Department of Basic Medical Sciences, Neurosciences, and Sensory Organs, University of Bari Medical School, Piazza Giulio Cesare 11, 70100 Bari, Italy; Cancer Institute "Giovanni Paolo II", 70100 Bari, Italy.Department of Pharmacy-Drug Sciences, University of Bari "Aldo Moro", Via Orabona 4, 70125 Bari, Italy. Electronic address: delia.mandracchia@uniba.it.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30092982

Citation

Tripodo, G, et al. "Hydrogels for Biomedical Applications From Glycol Chitosan and PEG Diglycidyl Ether Exhibit Pro-angiogenic and Antibacterial Activity." Carbohydrate Polymers, vol. 198, 2018, pp. 124-130.
Tripodo G, Trapani A, Rosato A, et al. Hydrogels for biomedical applications from glycol chitosan and PEG diglycidyl ether exhibit pro-angiogenic and antibacterial activity. Carbohydr Polym. 2018;198:124-130.
Tripodo, G., Trapani, A., Rosato, A., Di Franco, C., Tamma, R., Trapani, G., ... Mandracchia, D. (2018). Hydrogels for biomedical applications from glycol chitosan and PEG diglycidyl ether exhibit pro-angiogenic and antibacterial activity. Carbohydrate Polymers, 198, pp. 124-130. doi:10.1016/j.carbpol.2018.06.061.
Tripodo G, et al. Hydrogels for Biomedical Applications From Glycol Chitosan and PEG Diglycidyl Ether Exhibit Pro-angiogenic and Antibacterial Activity. Carbohydr Polym. 2018 Oct 15;198:124-130. PubMed PMID: 30092982.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hydrogels for biomedical applications from glycol chitosan and PEG diglycidyl ether exhibit pro-angiogenic and antibacterial activity. AU - Tripodo,G, AU - Trapani,A, AU - Rosato,A, AU - Di Franco,C, AU - Tamma,R, AU - Trapani,G, AU - Ribatti,D, AU - Mandracchia,D, Y1 - 2018/06/18/ PY - 2018/02/28/received PY - 2018/05/02/revised PY - 2018/06/14/accepted PY - 2018/8/11/entrez PY - 2018/8/11/pubmed PY - 2018/10/20/medline KW - Angiogenesis KW - Antibacterial KW - Crosslinking KW - Ethylene glycol diglycidyl ether (PubMed CID: 16683) KW - Glycol chitosan KW - Glycol chitosan (PubMed CID: 131636552) KW - Hydrogel KW - PEG diglycidyl ether SP - 124 EP - 130 JF - Carbohydrate polymers JO - Carbohydr Polym VL - 198 N2 - We aimed at producing a hydrogel from a chitosan (CS) derivative soluble in physiological conditions to avoid any purification step thus allowing to use the materials also as an in-situ forming material. So, we crosslinked glycol chitosan (GCS) with poly(ethylene glycol) diglycidyl ether (PEGDE) in water at 37 °C. The scaffolds, referred as GCS-PEG, were specifically designed to be used as wound dressing materials as such (after crosslinking) or as in-situ forming materials. Different amounts of PEGDE were tested. The obtained scaffolds showed macroscopic pores and a tailorable swelling in water by controlling the crosslinking degree. Moreover, GCS-PEG scaffolds displayed a significant antimicrobial activity against Staphylococcus aureus. In-vivo study using the chick embryo choriallantoic membrane resulted in a highly pronounced pro-angiogenic activity suggesting important tissue regeneration properties. Moreover, the employed materials are commercially available, no organic solvents are required and the scaling up is quite predictable. SN - 1879-1344 UR - https://www.unboundmedicine.com/medline/citation/30092982/Hydrogels_for_biomedical_applications_from_glycol_chitosan_and_PEG_diglycidyl_ether_exhibit_pro_angiogenic_and_antibacterial_activity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0144-8617(18)30715-X DB - PRIME DP - Unbound Medicine ER -