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Administration of antithymocyte serum modifies the response of Calomys musculinus to junin virus infection.
Intervirology. 1986; 25(1):56-60.I

Abstract

Approximately 80% of Calomys musculinus inoculated with an attenuated strain of Junin virus (JV) developed a lethal encephalitis. Antithymocyte serum, a potent suppressor of T-cell-mediated immunity, was studied for its effect on JV pathogenicity. Early administration of an anti-C. musculinus thymocyte serum (ACTS) to neonatal animals significantly diminished clinical disease and death and abrogated brain damage, which is usually associated with viral presence in the brain. Late ACTS administration did not modify the pattern of JV infection. These results suggest that immune mechanisms participate in the pathogenesis of JV infection for its main natural host.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3009353

Citation

Coulombié, F C., et al. "Administration of Antithymocyte Serum Modifies the Response of Calomys Musculinus to Junin Virus Infection." Intervirology, vol. 25, no. 1, 1986, pp. 56-60.
Coulombié FC, Laguens RM, Coto CE. Administration of antithymocyte serum modifies the response of Calomys musculinus to junin virus infection. Intervirology. 1986;25(1):56-60.
Coulombié, F. C., Laguens, R. M., & Coto, C. E. (1986). Administration of antithymocyte serum modifies the response of Calomys musculinus to junin virus infection. Intervirology, 25(1), 56-60.
Coulombié FC, Laguens RM, Coto CE. Administration of Antithymocyte Serum Modifies the Response of Calomys Musculinus to Junin Virus Infection. Intervirology. 1986;25(1):56-60. PubMed PMID: 3009353.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Administration of antithymocyte serum modifies the response of Calomys musculinus to junin virus infection. AU - Coulombié,F C, AU - Laguens,R M, AU - Coto,C E, PY - 1986/1/1/pubmed PY - 1986/1/1/medline PY - 1986/1/1/entrez SP - 56 EP - 60 JF - Intervirology JO - Intervirology VL - 25 IS - 1 N2 - Approximately 80% of Calomys musculinus inoculated with an attenuated strain of Junin virus (JV) developed a lethal encephalitis. Antithymocyte serum, a potent suppressor of T-cell-mediated immunity, was studied for its effect on JV pathogenicity. Early administration of an anti-C. musculinus thymocyte serum (ACTS) to neonatal animals significantly diminished clinical disease and death and abrogated brain damage, which is usually associated with viral presence in the brain. Late ACTS administration did not modify the pattern of JV infection. These results suggest that immune mechanisms participate in the pathogenesis of JV infection for its main natural host. SN - 0300-5526 UR - https://www.unboundmedicine.com/medline/citation/3009353/Administration_of_antithymocyte_serum_modifies_the_response_of_Calomys_musculinus_to_junin_virus_infection_ L2 - https://www.karger.com?DOI=10.1159/000149655 DB - PRIME DP - Unbound Medicine ER -