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[A Randomized Controlled Clinical Trial of Treatment of Moderate and Severe Persistent Allergic Rhinitis of Spleen Deficiency Pattern by Herbal Cake-partitioned Moxibustion Combined with Rhinocort Nasal Spray].
Zhen Ci Yan Jiu 2018; 43(7):450-5ZC

Abstract

OBJECTIVE

To evaluate the clinical effect of herbal cake-partitioned moxibustion combined with medication in the treatment of moderate and severe persistent allergic rhinitis (PAR) patients of spleen deficiency pattern.

METHODS

Sixty patients with moderate and severe PAR of spleen deficiency pattern were randomized into medication (Rhinocort) group and herbal cake-partitioned moxibustion combined with medication group (combination group, n=30 cases in each). Medicinal cake-partitioned moxibustion was applied to Yintang (GV 29, for about 20 min), Shenque(CV 8, about 50 min), bilateral Zusanli (ST 36, about 40 min)and Hegu(LI 4, about 40 min)once every other day for successive 8 weeks. All the patients received treatment with Rhinocort nasal spray, 2 jets/day for each nostril (64 µg/jet) for 8 weeks. The patients' conditions (symptoms of nasal sufferings, sleeping, sniffle, eye, emotion, etc.) were assessed by visual analogue scale (VAS) and rhino conjunctivitis quality of life questionnaire (RQLQ, 24 items of 7 aspects, 0-6 points/item), respectively. The spleen deficiency syndrome score was determined according to "Guiding Principles for Clinical Research of New Drugs of Chinese Materia Medica" (2002). The therapeutic effect was assessed by referring to "the Diagnostic and Therapeutic Principles and Recommended Schemes for Allergic Rhinitis" (2004).

RESULTS

Following the treatment, the scores of VAS, RQLQ, spleen deficiency syndrome were significantly decreased on the 4thand the 8th week of treatment in both groups in comparison with those of their own individual pre-treatment (P<0.05, P<0.01). Four weeks' follow-up survey showed that the VAS score and RQLQ score of the combination group were obviously lower than those of the medication groups (P<0.05), suggesting a better post-effect of moxibustion. Of the two 30 cases in the medication and combination groups, 9 and 9 experienced marked improvement in their symptoms, 16 and 17 were effective, and 5 and 4 ineffective, with the effective rate being 83.3% and 86.7%, respectively. No significant differences were found between the two groups in the VAS and RQLQ scores on the 4th and 8th week during treatment and in the effective rate (P>0.05).

CONCLUSION

Herbal cake-partitioned moxibustion combined with hormone (Rhinocort) nasal spray is effective in relieving symptoms of moderate and severe PAR patients of spleen deficiency syndrome, and has a better post-effect.

Authors+Show Affiliations

Derpartment of Acupuncture-moxibustion, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China.Derpartment of Acupuncture-moxibustion, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China.Derpartment of Acupuncture-moxibustion, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China.Derpartment of Acupuncture-moxibustion, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China.Derpartment of Otorhinolaryngology, Chaoyang Hospital, Capital Medical University, Beijing 100020.Derpartment of Acupuncture-moxibustion, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China.Derpartment of Acupuncture-moxibustion, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China.Derpartment of Acupuncture-moxibustion, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China.Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

chi

PubMed ID

30094983

Citation

Qu, Shu-Han, et al. "[A Randomized Controlled Clinical Trial of Treatment of Moderate and Severe Persistent Allergic Rhinitis of Spleen Deficiency Pattern By Herbal Cake-partitioned Moxibustion Combined With Rhinocort Nasal Spray]." Zhen Ci Yan Jiu = Acupuncture Research, vol. 43, no. 7, 2018, pp. 450-5.
Qu SH, Zhao JP, Chen S, et al. [A Randomized Controlled Clinical Trial of Treatment of Moderate and Severe Persistent Allergic Rhinitis of Spleen Deficiency Pattern by Herbal Cake-partitioned Moxibustion Combined with Rhinocort Nasal Spray]. Zhen Ci Yan Jiu. 2018;43(7):450-5.
Qu, S. H., Zhao, J. P., Chen, S., Wen, Z. H., Zhang, Y., Hou, X. S., ... Jing, X. H. (2018). [A Randomized Controlled Clinical Trial of Treatment of Moderate and Severe Persistent Allergic Rhinitis of Spleen Deficiency Pattern by Herbal Cake-partitioned Moxibustion Combined with Rhinocort Nasal Spray]. Zhen Ci Yan Jiu = Acupuncture Research, 43(7), pp. 450-5. doi:10.13702/j.1000-0607.170662.
Qu SH, et al. [A Randomized Controlled Clinical Trial of Treatment of Moderate and Severe Persistent Allergic Rhinitis of Spleen Deficiency Pattern By Herbal Cake-partitioned Moxibustion Combined With Rhinocort Nasal Spray]. Zhen Ci Yan Jiu. 2018 Jul 25;43(7):450-5. PubMed PMID: 30094983.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [A Randomized Controlled Clinical Trial of Treatment of Moderate and Severe Persistent Allergic Rhinitis of Spleen Deficiency Pattern by Herbal Cake-partitioned Moxibustion Combined with Rhinocort Nasal Spray]. AU - Qu,Shu-Han, AU - Zhao,Ji-Ping, AU - Chen,Sheng, AU - Wen,Zhi-Hong, AU - Zhang,Yi, AU - Hou,Xue-Si, AU - Zeng,Wei-Mei, AU - Jia,Yi-Fan, AU - Jing,Xiang-Hong, PY - 2018/8/11/entrez PY - 2018/8/11/pubmed PY - 2019/4/6/medline KW - Allergic rhinitis KW - Combined treatment KW - Herbal cake-partitioned moxibustion KW - Randomized controlled trial (RCT) SP - 450 EP - 5 JF - Zhen ci yan jiu = Acupuncture research JO - Zhen Ci Yan Jiu VL - 43 IS - 7 N2 - OBJECTIVE: To evaluate the clinical effect of herbal cake-partitioned moxibustion combined with medication in the treatment of moderate and severe persistent allergic rhinitis (PAR) patients of spleen deficiency pattern. METHODS: Sixty patients with moderate and severe PAR of spleen deficiency pattern were randomized into medication (Rhinocort) group and herbal cake-partitioned moxibustion combined with medication group (combination group, n=30 cases in each). Medicinal cake-partitioned moxibustion was applied to Yintang (GV 29, for about 20 min), Shenque(CV 8, about 50 min), bilateral Zusanli (ST 36, about 40 min)and Hegu(LI 4, about 40 min)once every other day for successive 8 weeks. All the patients received treatment with Rhinocort nasal spray, 2 jets/day for each nostril (64 µg/jet) for 8 weeks. The patients' conditions (symptoms of nasal sufferings, sleeping, sniffle, eye, emotion, etc.) were assessed by visual analogue scale (VAS) and rhino conjunctivitis quality of life questionnaire (RQLQ, 24 items of 7 aspects, 0-6 points/item), respectively. The spleen deficiency syndrome score was determined according to "Guiding Principles for Clinical Research of New Drugs of Chinese Materia Medica" (2002). The therapeutic effect was assessed by referring to "the Diagnostic and Therapeutic Principles and Recommended Schemes for Allergic Rhinitis" (2004). RESULTS: Following the treatment, the scores of VAS, RQLQ, spleen deficiency syndrome were significantly decreased on the 4thand the 8th week of treatment in both groups in comparison with those of their own individual pre-treatment (P<0.05, P<0.01). Four weeks' follow-up survey showed that the VAS score and RQLQ score of the combination group were obviously lower than those of the medication groups (P<0.05), suggesting a better post-effect of moxibustion. Of the two 30 cases in the medication and combination groups, 9 and 9 experienced marked improvement in their symptoms, 16 and 17 were effective, and 5 and 4 ineffective, with the effective rate being 83.3% and 86.7%, respectively. No significant differences were found between the two groups in the VAS and RQLQ scores on the 4th and 8th week during treatment and in the effective rate (P>0.05). CONCLUSION: Herbal cake-partitioned moxibustion combined with hormone (Rhinocort) nasal spray is effective in relieving symptoms of moderate and severe PAR patients of spleen deficiency syndrome, and has a better post-effect. SN - 1000-0607 UR - https://www.unboundmedicine.com/medline/citation/30094983/[A_Randomized_Controlled_Clinical_Trial_of_Treatment_of_Moderate_and_Severe_Persistent_Allergic_Rhinitis_of_Spleen_Deficiency_Pattern_by_Herbal_Cake_partitioned_Moxibustion_Combined_with_Rhinocort_Nasal_Spray]_ L2 - http://www.diseaseinfosearch.org/result/7665 DB - PRIME DP - Unbound Medicine ER -