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Experimental infection of Akodon molinae (Rodentia, Cricetidae) with Junín virus.
J Med Virol. 1986 May; 19(1):47-54.JM

Abstract

Experimental infection with the XJ-Clone 3 strain of Junín virus in laboratory bred Akodon molinae, a cricetid rodent inhabiting the borders of endemic Argentine hemorrhagic fever areas, was studied. Suckling animals inoculated intracerebrally proved sensitive and became chronically infected. Sixty percent of the rodents showed neurologic involvement, with mortality reaching 60%. Virus was recovered from the brain at 7, 15, 21, 37, and 57 days postinfection (pi). By immunofluorescence (IF), viral antigens were observed up to 182 days pi in cells of the central nervous system (CNS). Concurrently, immunoglobulin deposits were detected in infected CNS cells from 21 up to 182 days pi. These deposits increased with the progression of the immune response as measured by IF antibodies. The detection of immune complexes in brain cells of apparently healthy animals suggests that neither viral replication nor the development of a humoral immune response are necessary requisites for neurovirulence in this host. Infection of adult rodents by different routes failed to induce disease or mortality and virus could not be recovered from oral swabs, blood, or organs. Our data suggest that Akodon molinae could play a role in nature as an alternative reservoir of Junín virus in addition to the main reservoir, Calomys musculinus.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3009705

Citation

Carballal, G, et al. "Experimental Infection of Akodon Molinae (Rodentia, Cricetidae) With Junín Virus." Journal of Medical Virology, vol. 19, no. 1, 1986, pp. 47-54.
Carballal G, Videla C, Dulout F, et al. Experimental infection of Akodon molinae (Rodentia, Cricetidae) with Junín virus. J Med Virol. 1986;19(1):47-54.
Carballal, G., Videla, C., Dulout, F., Cossio, P. M., Acuña, A. M., & Bianchi, N. O. (1986). Experimental infection of Akodon molinae (Rodentia, Cricetidae) with Junín virus. Journal of Medical Virology, 19(1), 47-54.
Carballal G, et al. Experimental Infection of Akodon Molinae (Rodentia, Cricetidae) With Junín Virus. J Med Virol. 1986;19(1):47-54. PubMed PMID: 3009705.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Experimental infection of Akodon molinae (Rodentia, Cricetidae) with Junín virus. AU - Carballal,G, AU - Videla,C, AU - Dulout,F, AU - Cossio,P M, AU - Acuña,A M, AU - Bianchi,N O, PY - 1986/5/1/pubmed PY - 1986/5/1/medline PY - 1986/5/1/entrez SP - 47 EP - 54 JF - Journal of medical virology JO - J Med Virol VL - 19 IS - 1 N2 - Experimental infection with the XJ-Clone 3 strain of Junín virus in laboratory bred Akodon molinae, a cricetid rodent inhabiting the borders of endemic Argentine hemorrhagic fever areas, was studied. Suckling animals inoculated intracerebrally proved sensitive and became chronically infected. Sixty percent of the rodents showed neurologic involvement, with mortality reaching 60%. Virus was recovered from the brain at 7, 15, 21, 37, and 57 days postinfection (pi). By immunofluorescence (IF), viral antigens were observed up to 182 days pi in cells of the central nervous system (CNS). Concurrently, immunoglobulin deposits were detected in infected CNS cells from 21 up to 182 days pi. These deposits increased with the progression of the immune response as measured by IF antibodies. The detection of immune complexes in brain cells of apparently healthy animals suggests that neither viral replication nor the development of a humoral immune response are necessary requisites for neurovirulence in this host. Infection of adult rodents by different routes failed to induce disease or mortality and virus could not be recovered from oral swabs, blood, or organs. Our data suggest that Akodon molinae could play a role in nature as an alternative reservoir of Junín virus in addition to the main reservoir, Calomys musculinus. SN - 0146-6615 UR - https://www.unboundmedicine.com/medline/citation/3009705/Experimental_infection_of_Akodon_molinae__Rodentia_Cricetidae__with_Junín_virus_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0146-6615&date=1986&volume=19&issue=1&spage=47 DB - PRIME DP - Unbound Medicine ER -