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Dimethyl Sulfoxide-Induced Tonic-Clonic Seizure and Cardiac Arrest During Infusion of Autologous Peripheral Blood Stem Cells.
Cell Tissue Bank. 2018 Dec; 19(4):831-832.CT

Abstract

Various side effects associated with dimethyl sulfoxide (DMSO) which is used for cryopreservation of bone marrow or peripheral blood progenitor cells (PBPCs) have been reported. Among the central nervous system side effects the epileptic seizures, stroke, transient and temporary leucoencephalopathy, and global amnesia are well known. Herein we report a 52-year-old man who experienced tonic-clonic seizure within minutes after the initiation of DMSO cryopreserved autologous PBPC infusion. Unfortunately, he also developed cardiac arrest and required intubation for ventilation after the seizure. Pathophysiology of acute neurological and cardiac toxicity is unclear, but may also be idiosyncratic. Clinicians should be aware of the toxicity of cryoprotectant agents during PBSC infusion. Determining the risk factors associated with increased DMSO toxicity and taking preventive actions is utmost important.

Authors+Show Affiliations

Department of Hematology, Dıskapı Yildirim Beyazit Training and Research Hospital, Dışkapı Yıldırım Beyazıt E.A.H. Şehit Ömer Halisdemir Cad. Dışkapı, Ankara, Turkey. senemmaral@gmail.com.Department of Hematology, Dıskapı Yildirim Beyazit Training and Research Hospital, Dışkapı Yıldırım Beyazıt E.A.H. Şehit Ömer Halisdemir Cad. Dışkapı, Ankara, Turkey.Department of Hematology, Dıskapı Yildirim Beyazit Training and Research Hospital, Dışkapı Yıldırım Beyazıt E.A.H. Şehit Ömer Halisdemir Cad. Dışkapı, Ankara, Turkey.Department of Hematology, Dıskapı Yildirim Beyazit Training and Research Hospital, Dışkapı Yıldırım Beyazıt E.A.H. Şehit Ömer Halisdemir Cad. Dışkapı, Ankara, Turkey.Department of Hematology, Dıskapı Yildirim Beyazit Training and Research Hospital, Dışkapı Yıldırım Beyazıt E.A.H. Şehit Ömer Halisdemir Cad. Dışkapı, Ankara, Turkey.Department of Hematology, Dıskapı Yildirim Beyazit Training and Research Hospital, Dışkapı Yıldırım Beyazıt E.A.H. Şehit Ömer Halisdemir Cad. Dışkapı, Ankara, Turkey.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

30099684

Citation

Maral, Senem, et al. "Dimethyl Sulfoxide-Induced Tonic-Clonic Seizure and Cardiac Arrest During Infusion of Autologous Peripheral Blood Stem Cells." Cell and Tissue Banking, vol. 19, no. 4, 2018, pp. 831-832.
Maral S, Albayrak M, Pala C, et al. Dimethyl Sulfoxide-Induced Tonic-Clonic Seizure and Cardiac Arrest During Infusion of Autologous Peripheral Blood Stem Cells. Cell Tissue Bank. 2018;19(4):831-832.
Maral, S., Albayrak, M., Pala, C., Yildiz, A., Sahin, O., & Ozturk, H. B. (2018). Dimethyl Sulfoxide-Induced Tonic-Clonic Seizure and Cardiac Arrest During Infusion of Autologous Peripheral Blood Stem Cells. Cell and Tissue Banking, 19(4), 831-832. https://doi.org/10.1007/s10561-018-9718-x
Maral S, et al. Dimethyl Sulfoxide-Induced Tonic-Clonic Seizure and Cardiac Arrest During Infusion of Autologous Peripheral Blood Stem Cells. Cell Tissue Bank. 2018;19(4):831-832. PubMed PMID: 30099684.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dimethyl Sulfoxide-Induced Tonic-Clonic Seizure and Cardiac Arrest During Infusion of Autologous Peripheral Blood Stem Cells. AU - Maral,Senem, AU - Albayrak,Murat, AU - Pala,Cigdem, AU - Yildiz,Abdulkerim, AU - Sahin,Osman, AU - Ozturk,Hacer Berna, Y1 - 2018/08/11/ PY - 2018/02/11/received PY - 2018/07/28/accepted PY - 2018/8/14/pubmed PY - 2019/1/22/medline PY - 2018/8/13/entrez KW - Autologous stem cell KW - Dimethyl sulfoxide KW - Tonic–clonic seizure SP - 831 EP - 832 JF - Cell and tissue banking JO - Cell Tissue Bank VL - 19 IS - 4 N2 - Various side effects associated with dimethyl sulfoxide (DMSO) which is used for cryopreservation of bone marrow or peripheral blood progenitor cells (PBPCs) have been reported. Among the central nervous system side effects the epileptic seizures, stroke, transient and temporary leucoencephalopathy, and global amnesia are well known. Herein we report a 52-year-old man who experienced tonic-clonic seizure within minutes after the initiation of DMSO cryopreserved autologous PBPC infusion. Unfortunately, he also developed cardiac arrest and required intubation for ventilation after the seizure. Pathophysiology of acute neurological and cardiac toxicity is unclear, but may also be idiosyncratic. Clinicians should be aware of the toxicity of cryoprotectant agents during PBSC infusion. Determining the risk factors associated with increased DMSO toxicity and taking preventive actions is utmost important. SN - 1573-6814 UR - https://www.unboundmedicine.com/medline/citation/30099684/Dimethyl_Sulfoxide_Induced_Tonic_Clonic_Seizure_and_Cardiac_Arrest_During_Infusion_of_Autologous_Peripheral_Blood_Stem_Cells_ L2 - https://doi.org/10.1007/s10561-018-9718-x DB - PRIME DP - Unbound Medicine ER -