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Nutritional Metabolomics: Postprandial Response of Meals Relating to Vegan, Lacto-Ovo Vegetarian, and Omnivore Diets.
Nutrients. 2018 Aug 10; 10(8)N

Abstract

Metabolomics provide an unbiased tool for exploring the modulation of the human metabolome in response to food intake. This study applied metabolomics to capture the postprandial metabolic response to breakfast meals corresponding to vegan (VE), lacto ovo-vegetarian (LOV), and omnivore (OM) diets. In a cross over design 32 healthy volunteers (16 men and 16 females) consumed breakfast meals in a randomized order during three consecutive days. Fasting and 3 h postprandial serum samples were collected and then subjected to metabolite profiling using ¹H-nuclear magnetic resonance (NMR) spectroscopy. Changes in concentration of identified and discriminating metabolites, between fasting and postprandial state, were compared across meals. Betaine, choline, and creatine displayed higher concentration in the OM breakfast, while 3-hydroxyisobutyrate, carnitine, proline, and tyrosine showed an increase for the LOV and unidentified free fatty acids displayed a higher concentration after the VE breakfast. Using ¹H NMR metabolomics it was possible to detect and distinguish the metabolic response of three different breakfast meals corresponding to vegan, lacto-ovo vegetarian, and omnivore diets in serum.

Authors+Show Affiliations

Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, Box 459, 405 30 Gothenburg, Sweden. millie.radjursoga@gu.se.Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, Box 459, 405 30 Gothenburg, Sweden. helen.lindqvist@gu.se.Swedish NMR Centre, University of Gothenburg, Box 465, 405 30 Gothenburg, Sweden. anders.pedersen@nmr.gu.se.Swedish NMR Centre, University of Gothenburg, Box 465, 405 30 Gothenburg, Sweden. goran.karlsson@nmr.gu.se.Swedish NMR Centre, University of Gothenburg, Box 465, 405 30 Gothenburg, Sweden. daniel.malmodin@nmr.gu.se.Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, Box 459, 405 30 Gothenburg, Sweden. lasse.ellegard@nutrition.gu.se.Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, Box 459, 405 30 Gothenburg, Sweden. anna.winkvist@nutrition.gu.se.

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

30103400

Citation

Rådjursöga, Millie, et al. "Nutritional Metabolomics: Postprandial Response of Meals Relating to Vegan, Lacto-Ovo Vegetarian, and Omnivore Diets." Nutrients, vol. 10, no. 8, 2018.
Rådjursöga M, Lindqvist HM, Pedersen A, et al. Nutritional Metabolomics: Postprandial Response of Meals Relating to Vegan, Lacto-Ovo Vegetarian, and Omnivore Diets. Nutrients. 2018;10(8).
Rådjursöga, M., Lindqvist, H. M., Pedersen, A., Karlsson, B. G., Malmodin, D., Ellegård, L., & Winkvist, A. (2018). Nutritional Metabolomics: Postprandial Response of Meals Relating to Vegan, Lacto-Ovo Vegetarian, and Omnivore Diets. Nutrients, 10(8). https://doi.org/10.3390/nu10081063
Rådjursöga M, et al. Nutritional Metabolomics: Postprandial Response of Meals Relating to Vegan, Lacto-Ovo Vegetarian, and Omnivore Diets. Nutrients. 2018 Aug 10;10(8) PubMed PMID: 30103400.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nutritional Metabolomics: Postprandial Response of Meals Relating to Vegan, Lacto-Ovo Vegetarian, and Omnivore Diets. AU - Rådjursöga,Millie, AU - Lindqvist,Helen M, AU - Pedersen,Anders, AU - Karlsson,B Göran, AU - Malmodin,Daniel, AU - Ellegård,Lars, AU - Winkvist,Anna, Y1 - 2018/08/10/ PY - 2018/06/29/received PY - 2018/07/26/revised PY - 2018/08/06/accepted PY - 2018/8/15/entrez PY - 2018/8/15/pubmed PY - 2018/11/27/medline KW - NMR KW - diets KW - human metabolome KW - metabolomics KW - nutrition KW - omnivore KW - postprandial KW - serum KW - vegan KW - vegetarian JF - Nutrients JO - Nutrients VL - 10 IS - 8 N2 - Metabolomics provide an unbiased tool for exploring the modulation of the human metabolome in response to food intake. This study applied metabolomics to capture the postprandial metabolic response to breakfast meals corresponding to vegan (VE), lacto ovo-vegetarian (LOV), and omnivore (OM) diets. In a cross over design 32 healthy volunteers (16 men and 16 females) consumed breakfast meals in a randomized order during three consecutive days. Fasting and 3 h postprandial serum samples were collected and then subjected to metabolite profiling using ¹H-nuclear magnetic resonance (NMR) spectroscopy. Changes in concentration of identified and discriminating metabolites, between fasting and postprandial state, were compared across meals. Betaine, choline, and creatine displayed higher concentration in the OM breakfast, while 3-hydroxyisobutyrate, carnitine, proline, and tyrosine showed an increase for the LOV and unidentified free fatty acids displayed a higher concentration after the VE breakfast. Using ¹H NMR metabolomics it was possible to detect and distinguish the metabolic response of three different breakfast meals corresponding to vegan, lacto-ovo vegetarian, and omnivore diets in serum. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/30103400/Nutritional_Metabolomics:_Postprandial_Response_of_Meals_Relating_to_Vegan_Lacto_Ovo_Vegetarian_and_Omnivore_Diets_ L2 - https://www.mdpi.com/resolver?pii=nu10081063 DB - PRIME DP - Unbound Medicine ER -