Tags

Type your tag names separated by a space and hit enter

One-pot green synthesis and structural characterisation of silver nanoparticles using aqueous leaves extract of Carissa carandas: antioxidant, anticancer and antibacterial activities.
IET Nanobiotechnol. 2018 Sep; 12(6):748-756.IN

Abstract

Facile green synthesis of silver nanoparticles (AgNPs) using an aqueous extract of Carissa carandas (C. carandas) leaves was studied. Fabrication of AgNPs was confirmed by the UV-visible spectroscopy which gives absorption maxima at 420 nm. C. carandas leaves are the rich source of the bioactive molecules, acts as a reducing and stabilising agent in AgNPs, confirmed by Fourier transforms infrared spectroscopy. The field emission scanning electron microscope revealed the spherical shape of biosynthesised AgNPs. A distinctive peak of silver at 3 keV was determined by energy dispersive X-ray spectroscopy. X-ray diffraction showed the facecentred cubic structure of biosynthesised AgNPs and thermal stability was confirmed by the thermogravimetric analysis. Total flavonoid and total phenolic contents were evaluated in biosynthesised AgNPs. Biosynthesised AgNPs showed free radical scavenging activities against 2, 2-diphenyl-1-picrylhydrazyl test and ferric reducing antioxidant power assay. In vitro cytotoxicity against hepatic cell lines (HUH-7) and renal cell lines (HEK-293) were also assessed. Finally, biosynthesised AgNPs were scrutinised for their antibacterial activity against methicillin-resistant Staphylococcus aureus, Shigella sonnei, Shigella boydii and Salmonella typhimurium. This study demonstrated the biofabrication of AgNPs by using C. carandas leaves extract and a potential in vitro biological application as antioxidant, anticancer and antibacterial agents.

Authors+Show Affiliations

Department of Pharmaceutical Science, Faculty of Health Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences, Allahabad, UP 211007, India. deepika_singh1888@rediffmail.com.Natural Product Drug Discovery Laboratory, Department of Pharmaceutical Sciences, Faculty of Health Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences, Allahabad, UP 211007, India.Department of Pharmaceutical Science, Faculty of Health Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences, Allahabad, UP 211007, India.Department of Pharmaceutical Science, Faculty of Health Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences, Allahabad, UP 211007, India.Department of Computer Sciences, HMFA Institute of Engineering and Technology, Handia, Allahabad, UP, India.Department of Mechanical & Industrial Engineering, Indian Institute of Technology, Roorkee, Uttrakhand, India.Bio-organic & Medicinal Chemistry Research Laboratory, Department of Pharmaceutical Sciences, Faculty of Health Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences, Allahabad, UP 211007, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30104448

Citation

Singh, Deepika, et al. "One-pot Green Synthesis and Structural Characterisation of Silver Nanoparticles Using Aqueous Leaves Extract of Carissa Carandas: Antioxidant, Anticancer and Antibacterial Activities." IET Nanobiotechnology, vol. 12, no. 6, 2018, pp. 748-756.
Singh D, Kumar V, Yadav E, et al. One-pot green synthesis and structural characterisation of silver nanoparticles using aqueous leaves extract of Carissa carandas: antioxidant, anticancer and antibacterial activities. IET Nanobiotechnol. 2018;12(6):748-756.
Singh, D., Kumar, V., Yadav, E., Falls, N., Singh, M., Komal, U., & Verma, A. (2018). One-pot green synthesis and structural characterisation of silver nanoparticles using aqueous leaves extract of Carissa carandas: antioxidant, anticancer and antibacterial activities. IET Nanobiotechnology, 12(6), 748-756. https://doi.org/10.1049/iet-nbt.2017.0261
Singh D, et al. One-pot Green Synthesis and Structural Characterisation of Silver Nanoparticles Using Aqueous Leaves Extract of Carissa Carandas: Antioxidant, Anticancer and Antibacterial Activities. IET Nanobiotechnol. 2018;12(6):748-756. PubMed PMID: 30104448.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - One-pot green synthesis and structural characterisation of silver nanoparticles using aqueous leaves extract of Carissa carandas: antioxidant, anticancer and antibacterial activities. AU - Singh,Deepika, AU - Kumar,Vikas, AU - Yadav,Ekta, AU - Falls,Neha, AU - Singh,Manvendra, AU - Komal,Ujendra, AU - Verma,Amita, PY - 2018/8/15/entrez PY - 2018/8/15/pubmed PY - 2019/10/8/medline SP - 748 EP - 756 JF - IET nanobiotechnology JO - IET Nanobiotechnol VL - 12 IS - 6 N2 - Facile green synthesis of silver nanoparticles (AgNPs) using an aqueous extract of Carissa carandas (C. carandas) leaves was studied. Fabrication of AgNPs was confirmed by the UV-visible spectroscopy which gives absorption maxima at 420 nm. C. carandas leaves are the rich source of the bioactive molecules, acts as a reducing and stabilising agent in AgNPs, confirmed by Fourier transforms infrared spectroscopy. The field emission scanning electron microscope revealed the spherical shape of biosynthesised AgNPs. A distinctive peak of silver at 3 keV was determined by energy dispersive X-ray spectroscopy. X-ray diffraction showed the facecentred cubic structure of biosynthesised AgNPs and thermal stability was confirmed by the thermogravimetric analysis. Total flavonoid and total phenolic contents were evaluated in biosynthesised AgNPs. Biosynthesised AgNPs showed free radical scavenging activities against 2, 2-diphenyl-1-picrylhydrazyl test and ferric reducing antioxidant power assay. In vitro cytotoxicity against hepatic cell lines (HUH-7) and renal cell lines (HEK-293) were also assessed. Finally, biosynthesised AgNPs were scrutinised for their antibacterial activity against methicillin-resistant Staphylococcus aureus, Shigella sonnei, Shigella boydii and Salmonella typhimurium. This study demonstrated the biofabrication of AgNPs by using C. carandas leaves extract and a potential in vitro biological application as antioxidant, anticancer and antibacterial agents. SN - 1751-8741 UR - https://www.unboundmedicine.com/medline/citation/30104448/One_pot_green_synthesis_and_structural_characterisation_of_silver_nanoparticles_using_aqueous_leaves_extract_of_Carissa_carandas:_antioxidant_anticancer_and_antibacterial_activities_ L2 - https://doi.org/10.1049/iet-nbt.2017.0261 DB - PRIME DP - Unbound Medicine ER -