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Patient's perception: shorter and more severe prodromal phase in GBA-associated PD.
Eur J Neurol 2019; 26(4):694-698EJ

Abstract

BACKGROUND

Prevalence and time of occurrence of prodromal symptoms of Parkinson's disease (PD) in relation to the onset of classical motor manifestation varies between patients. Possible modifying factors might be different genetic architectures predisposing to varying burden of manifestations.

OBJECTIVES

To characterize the prodromal phase in PD patients with heterozygous mutations in the GBA gene compared to PD patients without GBA mutation.

METHODS

In a retrospective design, 151 participants [47 PD patients carrying a GBA mutation (PDGBA), 52 idiopathic PD patients (PDidiopathic), 52 healthy elderly (CON)] underwent a validated structured interview designed to assess prevalence and time of occurrence of prodromal symptoms.

RESULTS

PDGBA showed a higher prevalence of prodromal symptoms and almost simultaneous occurrence of non-motor and early motor symptoms shortly before PD diagnosis whereas PDidiopathic reported a longer prodromal phase starting with non-motor symptoms.

CONCLUSION

The short and severe prodromal phase in PDGBA might call for shorter assessment intervals in yet premanifest GBA mutation carriers.

Authors+Show Affiliations

Department of Neurodegeneration, Hertie-Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany. German Center for Neurodegenerative Diseases (DZNE), Tuebingen, Germany.Department of Neurodegeneration, Hertie-Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany. German Center for Neurodegenerative Diseases (DZNE), Tuebingen, Germany.Department of Neurodegeneration, Hertie-Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany.Department of Neurodegeneration, Hertie-Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany. German Center for Neurodegenerative Diseases (DZNE), Tuebingen, Germany.Department of Neurodegeneration, Hertie-Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany. German Center for Neurodegenerative Diseases (DZNE), Tuebingen, Germany.Department of Neurodegeneration, Hertie-Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany. German Center for Neurodegenerative Diseases (DZNE), Tuebingen, Germany.Gertrudis Klinik, Leun-Biskirchen, Germany.Department of Neurodegeneration, Hertie-Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany. Department of Neurology, Christian-Albrechts-University of Kiel, Kiel, Germany.Department of Neurodegeneration, Hertie-Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany. German Center for Neurodegenerative Diseases (DZNE), Tuebingen, Germany.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30107068

Citation

Zimmermann, M, et al. "Patient's Perception: Shorter and More Severe Prodromal Phase in GBA-associated PD." European Journal of Neurology, vol. 26, no. 4, 2019, pp. 694-698.
Zimmermann M, Gaenslen A, Prahl K, et al. Patient's perception: shorter and more severe prodromal phase in GBA-associated PD. Eur J Neurol. 2019;26(4):694-698.
Zimmermann, M., Gaenslen, A., Prahl, K., Srulijes, K., Hauser, A. K., Schulte, C., ... Brockmann, K. (2019). Patient's perception: shorter and more severe prodromal phase in GBA-associated PD. European Journal of Neurology, 26(4), pp. 694-698. doi:10.1111/ene.13776.
Zimmermann M, et al. Patient's Perception: Shorter and More Severe Prodromal Phase in GBA-associated PD. Eur J Neurol. 2019;26(4):694-698. PubMed PMID: 30107068.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Patient's perception: shorter and more severe prodromal phase in GBA-associated PD. AU - Zimmermann,M, AU - Gaenslen,A, AU - Prahl,K, AU - Srulijes,K, AU - Hauser,A-K, AU - Schulte,C, AU - Csoti,I, AU - Berg,D, AU - Brockmann,K, Y1 - 2018/09/14/ PY - 2018/02/09/received PY - 2018/08/09/accepted PY - 2018/8/15/pubmed PY - 2018/8/15/medline PY - 2018/8/15/entrez KW - GBA KW - Parkinson's disease KW - Prodromal phase SP - 694 EP - 698 JF - European journal of neurology JO - Eur. J. Neurol. VL - 26 IS - 4 N2 - BACKGROUND: Prevalence and time of occurrence of prodromal symptoms of Parkinson's disease (PD) in relation to the onset of classical motor manifestation varies between patients. Possible modifying factors might be different genetic architectures predisposing to varying burden of manifestations. OBJECTIVES: To characterize the prodromal phase in PD patients with heterozygous mutations in the GBA gene compared to PD patients without GBA mutation. METHODS: In a retrospective design, 151 participants [47 PD patients carrying a GBA mutation (PDGBA), 52 idiopathic PD patients (PDidiopathic), 52 healthy elderly (CON)] underwent a validated structured interview designed to assess prevalence and time of occurrence of prodromal symptoms. RESULTS: PDGBA showed a higher prevalence of prodromal symptoms and almost simultaneous occurrence of non-motor and early motor symptoms shortly before PD diagnosis whereas PDidiopathic reported a longer prodromal phase starting with non-motor symptoms. CONCLUSION: The short and severe prodromal phase in PDGBA might call for shorter assessment intervals in yet premanifest GBA mutation carriers. SN - 1468-1331 UR - https://www.unboundmedicine.com/medline/citation/30107068/Patient's_perception:_shorter_and_more_severe_prodromal_phase_in_GBA_associated_PD_ L2 - https://doi.org/10.1111/ene.13776 DB - PRIME DP - Unbound Medicine ER -