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Lidocaine-prilocaine cream versus local infiltration anesthesia in pain relief during repair of perineal trauma after vaginal delivery: a systematic review and meta-analysis.

Abstract

BACKGROUND

Perineal trauma is a common problem that may affect women during vaginal delivery; this trauma can be either spontaneous (tear) or intentional (episiotomy). When repair of perineal trauma is required, adequate analgesics must be obtained. Topical products as lidocaine-prilocaine (EMLA) cream is one of the suggested methods, but still there is lack of evidence with regard to its efficacy and safety.

OBJECTIVE

The aim of this review is to assess the evidence of utilizing EMLA cream in comparison to local perineal infiltration anesthesia for pain control during perineal repair after vaginal delivery.

DATA SOURCES

Medline, Embase, Dynamed Plus, ScienceDirect, TRIP database, ClinicalTrials.gov and the Cochrane Library were searched electronically from January 2006 to May 2018 for studies investigating the effect of lidocaine-prilocaine cream in relieving pain during repair of perineal trauma.

METHODS OF STUDY SELECTION

All randomized controlled trials assessing effect of lidocaine-prilocaine cream versus local infiltration anesthesia in relieving pain during repair of perineal trauma were considered for this meta-analysis. Fifteen studies were identified of which four studies deemed eligible for this review. Quality and risk of bias assessment was performed for all studies.

DATA EXTRACTION

Two researchers independently extracted the data from the individual articles and entered into RevMan software. The weighted mean difference (WMD) and 95% confidence interval (CI) was calculated. Statistical heterogeneity between studies was assessed by the Higgins chi-square and (I2) statistics. When heterogeneity was significant, a random-effects model was used for meta-analysis. Otherwise, the fixed effect meta-analysis was used when there was no significant heterogeneity.

RESULTS

Pooled analysis of result in "pain score" was insignificant between the two groups (WMD -1.11; 95% CI (-2.55 to 0.33); p = .13). Furthermore, the use of additional analgesia showed no statistically significant difference between the two groups (WMD 1.34; 95% CI (0.66-2.71), p = .42). Regarding patient satisfaction, an overall analysis of three studies showed significant results favoring EMLA cream group users (WMD 4.65; 95% CI (1.96-11.03), p = .0005). The pooled analysis of the outcome "duration of repair" showed the significantly shorter duration of repair in EMLA cream users (n = 92) than local infiltration anesthesia (n = 95) (1.72 min; 95% CI (-2.76 to -0.67), p = .001).

CONCLUSIONS

This meta-analysis suggests that topical lidocaine-prilocaine cream gives comparable results in reducing pain during perineal repair after vaginal delivery.

Authors+Show Affiliations

a Department of Obstetrics and Gynaecology, Faculty of Medicine , Assiut University , Assiut , Egypt.a Department of Obstetrics and Gynaecology, Faculty of Medicine , Assiut University , Assiut , Egypt. b Department of Obstetrics and Gynaecology , University of Nottingham, Royal Derby Hospital , Derby , United Kingdom.c Kasr Al-Ainy Faculty of Medicine , Cairo University , Cairo , Egypt.d Derby Teaching Hospitals NHS Foundation Trust , Derby , United Kingdom.d Derby Teaching Hospitals NHS Foundation Trust , Derby , United Kingdom.c Kasr Al-Ainy Faculty of Medicine , Cairo University , Cairo , Egypt.a Department of Obstetrics and Gynaecology, Faculty of Medicine , Assiut University , Assiut , Egypt.e Department of Obstetrics and Gynaecology, Faculty of Medicine , Beni-Suef University , Cairo , Egypt.f Department of Obstetrics and Gynaecology, Faculty of Medicine , Cairo University , Cairo , Egypt.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30107755

Citation

Abbas, Ahmed M., et al. "Lidocaine-prilocaine Cream Versus Local Infiltration Anesthesia in Pain Relief During Repair of Perineal Trauma After Vaginal Delivery: a Systematic Review and Meta-analysis." The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2018, pp. 1-8.
Abbas AM, Mohamed AA, Mattar OM, et al. Lidocaine-prilocaine cream versus local infiltration anesthesia in pain relief during repair of perineal trauma after vaginal delivery: a systematic review and meta-analysis. J Matern Fetal Neonatal Med. 2018.
Abbas, A. M., Mohamed, A. A., Mattar, O. M., El Shamy, T., James, C., Namous, L. O., ... Samy, A. (2018). Lidocaine-prilocaine cream versus local infiltration anesthesia in pain relief during repair of perineal trauma after vaginal delivery: a systematic review and meta-analysis. The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, pp. 1-8. doi:10.1080/14767058.2018.1512576.
Abbas AM, et al. Lidocaine-prilocaine Cream Versus Local Infiltration Anesthesia in Pain Relief During Repair of Perineal Trauma After Vaginal Delivery: a Systematic Review and Meta-analysis. J Matern Fetal Neonatal Med. 2018 Sep 5;1-8. PubMed PMID: 30107755.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lidocaine-prilocaine cream versus local infiltration anesthesia in pain relief during repair of perineal trauma after vaginal delivery: a systematic review and meta-analysis. AU - Abbas,Ahmed M, AU - Mohamed,Ahmed A, AU - Mattar,Omar M, AU - El Shamy,Tarek, AU - James,Cathryn, AU - Namous,Lubaba O, AU - Yosef,Ali H, AU - Khamis,Yasser, AU - Samy,Ahmed, Y1 - 2018/09/05/ PY - 2018/8/16/pubmed PY - 2018/8/16/medline PY - 2018/8/16/entrez KW - Episiotomy KW - lidocaine-prilocaine KW - local anesthesia KW - perineal tear KW - vaginal delivery SP - 1 EP - 8 JF - The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians JO - J. Matern. Fetal. Neonatal. Med. N2 - BACKGROUND: Perineal trauma is a common problem that may affect women during vaginal delivery; this trauma can be either spontaneous (tear) or intentional (episiotomy). When repair of perineal trauma is required, adequate analgesics must be obtained. Topical products as lidocaine-prilocaine (EMLA) cream is one of the suggested methods, but still there is lack of evidence with regard to its efficacy and safety. OBJECTIVE: The aim of this review is to assess the evidence of utilizing EMLA cream in comparison to local perineal infiltration anesthesia for pain control during perineal repair after vaginal delivery. DATA SOURCES: Medline, Embase, Dynamed Plus, ScienceDirect, TRIP database, ClinicalTrials.gov and the Cochrane Library were searched electronically from January 2006 to May 2018 for studies investigating the effect of lidocaine-prilocaine cream in relieving pain during repair of perineal trauma. METHODS OF STUDY SELECTION: All randomized controlled trials assessing effect of lidocaine-prilocaine cream versus local infiltration anesthesia in relieving pain during repair of perineal trauma were considered for this meta-analysis. Fifteen studies were identified of which four studies deemed eligible for this review. Quality and risk of bias assessment was performed for all studies. DATA EXTRACTION: Two researchers independently extracted the data from the individual articles and entered into RevMan software. The weighted mean difference (WMD) and 95% confidence interval (CI) was calculated. Statistical heterogeneity between studies was assessed by the Higgins chi-square and (I2) statistics. When heterogeneity was significant, a random-effects model was used for meta-analysis. Otherwise, the fixed effect meta-analysis was used when there was no significant heterogeneity. RESULTS: Pooled analysis of result in "pain score" was insignificant between the two groups (WMD -1.11; 95% CI (-2.55 to 0.33); p = .13). Furthermore, the use of additional analgesia showed no statistically significant difference between the two groups (WMD 1.34; 95% CI (0.66-2.71), p = .42). Regarding patient satisfaction, an overall analysis of three studies showed significant results favoring EMLA cream group users (WMD 4.65; 95% CI (1.96-11.03), p = .0005). The pooled analysis of the outcome "duration of repair" showed the significantly shorter duration of repair in EMLA cream users (n = 92) than local infiltration anesthesia (n = 95) (1.72 min; 95% CI (-2.76 to -0.67), p = .001). CONCLUSIONS: This meta-analysis suggests that topical lidocaine-prilocaine cream gives comparable results in reducing pain during perineal repair after vaginal delivery. SN - 1476-4954 UR - https://www.unboundmedicine.com/medline/citation/30107755/Lidocaine-prilocaine_cream_versus_local_infiltration_anesthesia_in_pain_relief_during_repair_of_perineal_trauma_after_vaginal_delivery:_a_systematic_review_and_meta-analysis L2 - http://www.tandfonline.com/doi/full/10.1080/14767058.2018.1512576 DB - PRIME DP - Unbound Medicine ER -