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Bioactivity evaluations of betulin identified from the bark of Betula platyphylla var. japonica for cancer therapy.
Arch Pharm Res. 2018 Aug; 41(8):815-822.AP

Abstract

Identification of bioactive natural products with anticancer activity as well as alleviating effects on chemotherapy-induced side effects has significant implications for cancer treatment. Betula platyphylla var. japonica, commonly known as Asian white birch, has been used in Chinese traditional medicine for a variety of purposes. In this study, the medicinal properties of betulin from B. platyphylla var. japonica useful for cancer management were investigated. LC/MS analysis revealed that betulin is a main chemical component of the EtOH extract of B. platyphylla var. japonica bark, and betulin was isolated from EtOH extract using an LC/MS-guided isolation method. Its structure was identified with 1H and 13C NMR spectroscopic data and LC/MS analysis and then compared to the previously reported spectroscopic and physical data. We first verified the cytotoxicity of betulin against three human lung adenocarcinoma cell lines, A549, H1264, and Calu-6, with IC50 values ranging from 18.7 to 39.6 μM. Regarding alleviation of side effects associated with anticancer chemotherapy, betulin ameliorated cisplatin-induced renal cell damage to 80% of the control value from the concentration of 5 μM. In addition, betulin showed anti-gastritis activity against ethanol-induced gastric damage in rats and notably reduced the gastric damage index compared to control in a concentration-dependent manner. These findings provide the first experimental evidence for potential use of B. platyphylla var. japonica as a functional food for cancer treatment that simultaneously alleviates the side effects of chemotherapy.

Authors+Show Affiliations

School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea.School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea.School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea.School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea.College of Korean Medicine, Gachon University, Seongnam, 461-701, Republic of Korea.Research Center, Natural Medicine Research Team, Richwood Trading Company, LTD, Seoul, 08826, Republic of Korea.Department of Molecular and Cellular Biology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Suwon, 16419, Republic of Korea.Department of Food Science and Biotechnology, Kyonggi University, Suwon, 443-760, Republic of Korea.School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea. khkim83@skku.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30109574

Citation

So, Hae Min, et al. "Bioactivity Evaluations of Betulin Identified From the Bark of Betula Platyphylla Var. Japonica for Cancer Therapy." Archives of Pharmacal Research, vol. 41, no. 8, 2018, pp. 815-822.
So HM, Eom HJ, Lee D, et al. Bioactivity evaluations of betulin identified from the bark of Betula platyphylla var. japonica for cancer therapy. Arch Pharm Res. 2018;41(8):815-822.
So, H. M., Eom, H. J., Lee, D., Kim, S., Kang, K. S., Lee, I. K., Baek, K. H., Park, J. Y., & Kim, K. H. (2018). Bioactivity evaluations of betulin identified from the bark of Betula platyphylla var. japonica for cancer therapy. Archives of Pharmacal Research, 41(8), 815-822. https://doi.org/10.1007/s12272-018-1064-9
So HM, et al. Bioactivity Evaluations of Betulin Identified From the Bark of Betula Platyphylla Var. Japonica for Cancer Therapy. Arch Pharm Res. 2018;41(8):815-822. PubMed PMID: 30109574.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bioactivity evaluations of betulin identified from the bark of Betula platyphylla var. japonica for cancer therapy. AU - So,Hae Min, AU - Eom,Hee Jeong, AU - Lee,Dahae, AU - Kim,Sil, AU - Kang,Ki Sung, AU - Lee,Il Kyun, AU - Baek,Kwan-Hyuck, AU - Park,Jun Yeon, AU - Kim,Ki Hyun, Y1 - 2018/08/14/ PY - 2018/03/17/received PY - 2018/08/01/accepted PY - 2018/8/16/pubmed PY - 2018/11/9/medline PY - 2018/8/16/entrez KW - Anti-gastritis KW - Betula platyphylla var. japonica KW - Betulin KW - Cytotoxicity KW - Nephrotoxicity SP - 815 EP - 822 JF - Archives of pharmacal research JO - Arch Pharm Res VL - 41 IS - 8 N2 - Identification of bioactive natural products with anticancer activity as well as alleviating effects on chemotherapy-induced side effects has significant implications for cancer treatment. Betula platyphylla var. japonica, commonly known as Asian white birch, has been used in Chinese traditional medicine for a variety of purposes. In this study, the medicinal properties of betulin from B. platyphylla var. japonica useful for cancer management were investigated. LC/MS analysis revealed that betulin is a main chemical component of the EtOH extract of B. platyphylla var. japonica bark, and betulin was isolated from EtOH extract using an LC/MS-guided isolation method. Its structure was identified with 1H and 13C NMR spectroscopic data and LC/MS analysis and then compared to the previously reported spectroscopic and physical data. We first verified the cytotoxicity of betulin against three human lung adenocarcinoma cell lines, A549, H1264, and Calu-6, with IC50 values ranging from 18.7 to 39.6 μM. Regarding alleviation of side effects associated with anticancer chemotherapy, betulin ameliorated cisplatin-induced renal cell damage to 80% of the control value from the concentration of 5 μM. In addition, betulin showed anti-gastritis activity against ethanol-induced gastric damage in rats and notably reduced the gastric damage index compared to control in a concentration-dependent manner. These findings provide the first experimental evidence for potential use of B. platyphylla var. japonica as a functional food for cancer treatment that simultaneously alleviates the side effects of chemotherapy. SN - 0253-6269 UR - https://www.unboundmedicine.com/medline/citation/30109574/Bioactivity_evaluations_of_betulin_identified_from_the_bark_of_Betula_platyphylla_var__japonica_for_cancer_therapy_ L2 - https://dx.doi.org/10.1007/s12272-018-1064-9 DB - PRIME DP - Unbound Medicine ER -