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Cytokines, cortisol, and nitric oxide as salivary biomarkers in oral lichen planus: a systematic review.
Braz Oral Res. 2018 Aug 13; 32:e82.BO

Abstract

The etiopathogenesis of oral lichen planus (OLP) is still not fully elucidated, and it is believed that its development could involve a neuro-immune-endocrine profile. This systematic review investigated the relationship between cytokines, cortisol, and nitric oxide (NO) in the saliva of OLP patients. An electronic search was conducted in Pubmed/Medline, Scopus, LIVIVO, and Web of Science databases with no restriction of language to identify studies published up to December 2017. Data extraction was performed using the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines. A total of 140 articles were retrieved, and 32 articles fulfilled the inclusion criteria (cytokines = 17; cortisol = 9; NO = 6). The most studied cytokines in the saliva of OLP patients were interleukins IL-4, IL-6, IL-8, IFN-ү, and TNF-α, which were higher in OLP patients than in healthy controls (HC). Salivary cortisol was found to be higher in OLP than in HC in most (55.5%) of the selected studies, and all studies related to NO found higher levels of this marker in OLP than in HC. Despite controversial results, our review suggests that OLP patients have an increased inflammatory response, as indicated by the proinflammatory profile of salivary cytokines. In addition, we conclude that salivary cytokine and NO measurements may have significant diagnostic and prognostic potential for monitoring disease activity and therapeutic responses in OLP.

Authors+Show Affiliations

Universidade de São Paulo - USP, School of Dentistry of Ribeirão Preto, Department of Morphology, Physiology, and Basic Pathology, Ribeirão Preto, SP, Brazil.Universidade de São Paulo - USP, School of Dentistry of Ribeirão Preto, Department of Stomatology, Ribeirão Preto, SP, Brazil.Universidade de São Paulo - USP, School of Dentistry of Ribeirão Preto, Department of Morphology, Physiology, and Basic Pathology, Ribeirão Preto, SP, Brazil.Universidade de São Paulo - USP, School of Dentistry of Ribeirão Preto, Department of Stomatology, Ribeirão Preto, SP, Brazil.

Pub Type(s)

Journal Article
Review
Systematic Review

Language

eng

PubMed ID

30110084

Citation

Humberto, Janaina Silva Martins, et al. "Cytokines, Cortisol, and Nitric Oxide as Salivary Biomarkers in Oral Lichen Planus: a Systematic Review." Brazilian Oral Research, vol. 32, 2018, pp. e82.
Humberto JSM, Pavanin JV, Rocha MJAD, et al. Cytokines, cortisol, and nitric oxide as salivary biomarkers in oral lichen planus: a systematic review. Braz Oral Res. 2018;32:e82.
Humberto, J. S. M., Pavanin, J. V., Rocha, M. J. A. D., & Motta, A. C. F. (2018). Cytokines, cortisol, and nitric oxide as salivary biomarkers in oral lichen planus: a systematic review. Brazilian Oral Research, 32, e82. https://doi.org/10.1590/1807-3107bor-2018.vol32.0082
Humberto JSM, et al. Cytokines, Cortisol, and Nitric Oxide as Salivary Biomarkers in Oral Lichen Planus: a Systematic Review. Braz Oral Res. 2018 Aug 13;32:e82. PubMed PMID: 30110084.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytokines, cortisol, and nitric oxide as salivary biomarkers in oral lichen planus: a systematic review. AU - Humberto,Janaina Silva Martins, AU - Pavanin,Jefferson Veronezi, AU - Rocha,Maria José Alves da, AU - Motta,Ana Carolina Fragoso, Y1 - 2018/08/13/ PY - 2018/01/12/received PY - 2018/05/05/accepted PY - 2018/8/16/entrez PY - 2018/8/16/pubmed PY - 2018/9/7/medline SP - e82 EP - e82 JF - Brazilian oral research JO - Braz Oral Res VL - 32 N2 - The etiopathogenesis of oral lichen planus (OLP) is still not fully elucidated, and it is believed that its development could involve a neuro-immune-endocrine profile. This systematic review investigated the relationship between cytokines, cortisol, and nitric oxide (NO) in the saliva of OLP patients. An electronic search was conducted in Pubmed/Medline, Scopus, LIVIVO, and Web of Science databases with no restriction of language to identify studies published up to December 2017. Data extraction was performed using the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines. A total of 140 articles were retrieved, and 32 articles fulfilled the inclusion criteria (cytokines = 17; cortisol = 9; NO = 6). The most studied cytokines in the saliva of OLP patients were interleukins IL-4, IL-6, IL-8, IFN-ү, and TNF-α, which were higher in OLP patients than in healthy controls (HC). Salivary cortisol was found to be higher in OLP than in HC in most (55.5%) of the selected studies, and all studies related to NO found higher levels of this marker in OLP than in HC. Despite controversial results, our review suggests that OLP patients have an increased inflammatory response, as indicated by the proinflammatory profile of salivary cytokines. In addition, we conclude that salivary cytokine and NO measurements may have significant diagnostic and prognostic potential for monitoring disease activity and therapeutic responses in OLP. SN - 1807-3107 UR - https://www.unboundmedicine.com/medline/citation/30110084/Cytokines_cortisol_and_nitric_oxide_as_salivary_biomarkers_in_oral_lichen_planus:_a_systematic_review_ L2 - https://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242018000100403&lng=en&nrm=iso&tlng=en DB - PRIME DP - Unbound Medicine ER -