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Novel electrospun chitosan/polyvinyl alcohol/zinc oxide nanofibrous mats with antibacterial and antioxidant properties for diabetic wound healing.
Int J Biol Macromol. 2018 Dec; 120(Pt A):385-393.IJ

Abstract

Non-healing wound is a serious complication of diabetes, associated with extremely slow wound closure, and a high rate of infection, resulting in amputation or losses of limbs, high health care cost and poor quality of patient's life. In the present study, we hypothesized that nanofiber mats composed of a combination of chitosan, polyvinyl alcohol (PVA) and Zinc oxide (ZnO) could be an effective option for faster healing of diabetic wounds due to the wound healing activities of chitosan-PVA nanofibers and antibacterial properties of ZnO. Nanofiber mats of chitosan, PVA and ZnO were synthesized using electrospinning technique. The developed nanofibrous mats were characterized by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), antibacterial and antioxidant assays as well as in vivo wound healing experiments in rabbits. The results revealed that chitosan/PVA/ZnO nanofibrous membranes possessed higher antibacterial potential against E. coli, P. aeruginosa, B. subtilis and S. aureus compared to chitosan/PVA nanofibrous membranes. Moreover, chitosan/PVA/ZnO nanofibrous membranes exhibited higher antioxidant potential compared to chitosan/PVA nanofibrous mats. The in vivo wound healing studies showed that chitosan/PVA/ZnO nanofibrous membranes resulted in accelerated wound healing as compared to chitosan/PVA nanofibers. The current study, thus, reveals that chitosan/PVA/ZnO electrospun scaffolds could be effectively helpful in dressings for diabetic wounds.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Ahmed R
Department of Mechanical and Industrial Engineering, Qatar University, Doha, Qatar; Department of Biotechnology, Mirpur University of Science and Technology (MUST), Mirpur 10250, AJK, Pakistan.
Tariq M
Department of Biotechnology, Mirpur University of Science and Technology (MUST), Mirpur 10250, AJK, Pakistan. Electronic address: tariq.awan@must.edu.pk.
Ali I
Department of Biotechnology, Mirpur University of Science and Technology (MUST), Mirpur 10250, AJK, Pakistan.
Asghar R
Department of Biotechnology, Mirpur University of Science and Technology (MUST), Mirpur 10250, AJK, Pakistan.
Noorunnisa Khanam P
Department of Mechanical and Industrial Engineering, Qatar University, Doha, Qatar.
Augustine R
Department of Mechanical and Industrial Engineering, Qatar University, Doha, Qatar.
Hasan A
Department of Mechanical and Industrial Engineering, Qatar University, Doha, Qatar. Electronic address: ahasan@qu.edu.qa.

MeSH

AnimalsAnti-Bacterial AgentsAntioxidantsBandagesChitosanDiabetes MellitusEscherichia coliHumansNanofibersPolyvinyl AlcoholPseudomonas aeruginosaRabbitsStaphylococcus aureusWound HealingZinc Oxide

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30110603

Citation

Ahmed, Rashid, et al. "Novel Electrospun Chitosan/polyvinyl Alcohol/zinc Oxide Nanofibrous Mats With Antibacterial and Antioxidant Properties for Diabetic Wound Healing." International Journal of Biological Macromolecules, vol. 120, no. Pt A, 2018, pp. 385-393.
Ahmed R, Tariq M, Ali I, et al. Novel electrospun chitosan/polyvinyl alcohol/zinc oxide nanofibrous mats with antibacterial and antioxidant properties for diabetic wound healing. Int J Biol Macromol. 2018;120(Pt A):385-393.
Ahmed, R., Tariq, M., Ali, I., Asghar, R., Noorunnisa Khanam, P., Augustine, R., & Hasan, A. (2018). Novel electrospun chitosan/polyvinyl alcohol/zinc oxide nanofibrous mats with antibacterial and antioxidant properties for diabetic wound healing. International Journal of Biological Macromolecules, 120(Pt A), 385-393. https://doi.org/10.1016/j.ijbiomac.2018.08.057
Ahmed R, et al. Novel Electrospun Chitosan/polyvinyl Alcohol/zinc Oxide Nanofibrous Mats With Antibacterial and Antioxidant Properties for Diabetic Wound Healing. Int J Biol Macromol. 2018;120(Pt A):385-393. PubMed PMID: 30110603.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Novel electrospun chitosan/polyvinyl alcohol/zinc oxide nanofibrous mats with antibacterial and antioxidant properties for diabetic wound healing. AU - Ahmed,Rashid, AU - Tariq,Muhammad, AU - Ali,Imran, AU - Asghar,Rehana, AU - Noorunnisa Khanam,P, AU - Augustine,Robin, AU - Hasan,Anwarul, Y1 - 2018/08/12/ PY - 2018/04/26/received PY - 2018/08/09/revised PY - 2018/08/10/accepted PY - 2018/8/16/pubmed PY - 2019/1/8/medline PY - 2018/8/16/entrez KW - Chitosan KW - Diabetic wound healing KW - Electrospinning KW - Nanofibers KW - Polyvinyl alcohol KW - Zinc oxide SP - 385 EP - 393 JF - International journal of biological macromolecules JO - Int J Biol Macromol VL - 120 IS - Pt A N2 - Non-healing wound is a serious complication of diabetes, associated with extremely slow wound closure, and a high rate of infection, resulting in amputation or losses of limbs, high health care cost and poor quality of patient's life. In the present study, we hypothesized that nanofiber mats composed of a combination of chitosan, polyvinyl alcohol (PVA) and Zinc oxide (ZnO) could be an effective option for faster healing of diabetic wounds due to the wound healing activities of chitosan-PVA nanofibers and antibacterial properties of ZnO. Nanofiber mats of chitosan, PVA and ZnO were synthesized using electrospinning technique. The developed nanofibrous mats were characterized by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), antibacterial and antioxidant assays as well as in vivo wound healing experiments in rabbits. The results revealed that chitosan/PVA/ZnO nanofibrous membranes possessed higher antibacterial potential against E. coli, P. aeruginosa, B. subtilis and S. aureus compared to chitosan/PVA nanofibrous membranes. Moreover, chitosan/PVA/ZnO nanofibrous membranes exhibited higher antioxidant potential compared to chitosan/PVA nanofibrous mats. The in vivo wound healing studies showed that chitosan/PVA/ZnO nanofibrous membranes resulted in accelerated wound healing as compared to chitosan/PVA nanofibers. The current study, thus, reveals that chitosan/PVA/ZnO electrospun scaffolds could be effectively helpful in dressings for diabetic wounds. SN - 1879-0003 UR - https://www.unboundmedicine.com/medline/citation/30110603/Novel_electrospun_chitosan/polyvinyl_alcohol/zinc_oxide_nanofibrous_mats_with_antibacterial_and_antioxidant_properties_for_diabetic_wound_healing_ DB - PRIME DP - Unbound Medicine ER -