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Dietary Intake of Vitamin B12 is Better for Restoring a Low B12 Status Than a Daily High-Dose Vitamin Pill: An Experimental Study in Rats.
Nutrients. 2018 Aug 15; 10(8)N

Abstract

Vitamin B12 (B12) is present in foods of animal origin, and vegans are encouraged to take supplements with synthetic B12 in order to ensure a sufficient uptake. Recent rat studies suggest that natural (hydroxo-B12, HO-B12) and synthetic (cyano-B12, CN-B12) B12 behave differently in the body. Here, we test if a daily vitamin pill matches dietary B12 in ability to restore a low B12 status in rats. B12-depleted male Wistar rats (n = 60) were divided into five groups (n = 12 in each) and subjected to two weeks intervention with various schemes of B12 supplementation. Two "dietary" groups received a low-B12 chow that was fortified with either HO-B12 or CN-B12 providing a continuous supply. Two "pill" groups received a single daily dose of CN-B12, where the vitamin content either matched or exceeded by factor four the provisions for the "dietary" groups. A control group received the low-B12 chow without B12 fortification. B12 was measured in plasma and tissues. Dietary B12 provides 35% more B12 to the tissues than an equivalent single daily dose (p < 0.0001). Natural B12 delivers 25% more B12 to the liver than synthetic B12 (p = 0.0007). A fourfold increase in B12, supplemented as a single daily dose, does not provide any extra B12 to the tissues (p = 0.45). We conclude that dietary B12 is better at rescuing a low B12 status than a daily vitamin pill.

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Authors+Show Affiliations

Greibe E
Department of Clinical Biochemistry, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark. greibe@clin.au.dk.
Nymark O
Department of Clinical Biochemistry, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark. au335591@post.au.dk.
Fedosov SN
Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 10, 8000 Aarhus C, Denmark. SNFedosov1960@gmail.com.
Heegaard CW
Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 10, 8000 Aarhus C, Denmark. cwh@mbg.au.dk.
Nexo E
Department of Clinical Biochemistry, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark. e.nexo@dadlnet.dk.

MeSH

Animal FeedAnimalsDietDietary SupplementsMaleRatsRats, WistarVitamin B 12Vitamin B 12 Deficiency

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30111759

Citation

Greibe, Eva, et al. "Dietary Intake of Vitamin B12 Is Better for Restoring a Low B12 Status Than a Daily High-Dose Vitamin Pill: an Experimental Study in Rats." Nutrients, vol. 10, no. 8, 2018.
Greibe E, Nymark O, Fedosov SN, et al. Dietary Intake of Vitamin B12 is Better for Restoring a Low B12 Status Than a Daily High-Dose Vitamin Pill: An Experimental Study in Rats. Nutrients. 2018;10(8).
Greibe, E., Nymark, O., Fedosov, S. N., Heegaard, C. W., & Nexo, E. (2018). Dietary Intake of Vitamin B12 is Better for Restoring a Low B12 Status Than a Daily High-Dose Vitamin Pill: An Experimental Study in Rats. Nutrients, 10(8). https://doi.org/10.3390/nu10081096
Greibe E, et al. Dietary Intake of Vitamin B12 Is Better for Restoring a Low B12 Status Than a Daily High-Dose Vitamin Pill: an Experimental Study in Rats. Nutrients. 2018 Aug 15;10(8) PubMed PMID: 30111759.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary Intake of Vitamin B12 is Better for Restoring a Low B12 Status Than a Daily High-Dose Vitamin Pill: An Experimental Study in Rats. AU - Greibe,Eva, AU - Nymark,Ole, AU - Fedosov,Sergey N, AU - Heegaard,Christian W, AU - Nexo,Ebba, Y1 - 2018/08/15/ PY - 2018/07/06/received PY - 2018/08/13/revised PY - 2018/08/14/accepted PY - 2018/8/17/entrez PY - 2018/8/17/pubmed PY - 2018/12/13/medline KW - B12-depleted rats KW - cyanocobalamin KW - dietary vitamin B12 KW - hydroxocobalamin KW - tissue distribution KW - vegan KW - vitamin pills JF - Nutrients JO - Nutrients VL - 10 IS - 8 N2 - Vitamin B12 (B12) is present in foods of animal origin, and vegans are encouraged to take supplements with synthetic B12 in order to ensure a sufficient uptake. Recent rat studies suggest that natural (hydroxo-B12, HO-B12) and synthetic (cyano-B12, CN-B12) B12 behave differently in the body. Here, we test if a daily vitamin pill matches dietary B12 in ability to restore a low B12 status in rats. B12-depleted male Wistar rats (n = 60) were divided into five groups (n = 12 in each) and subjected to two weeks intervention with various schemes of B12 supplementation. Two "dietary" groups received a low-B12 chow that was fortified with either HO-B12 or CN-B12 providing a continuous supply. Two "pill" groups received a single daily dose of CN-B12, where the vitamin content either matched or exceeded by factor four the provisions for the "dietary" groups. A control group received the low-B12 chow without B12 fortification. B12 was measured in plasma and tissues. Dietary B12 provides 35% more B12 to the tissues than an equivalent single daily dose (p < 0.0001). Natural B12 delivers 25% more B12 to the liver than synthetic B12 (p = 0.0007). A fourfold increase in B12, supplemented as a single daily dose, does not provide any extra B12 to the tissues (p = 0.45). We conclude that dietary B12 is better at rescuing a low B12 status than a daily vitamin pill. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/30111759/Dietary_Intake_of_Vitamin_B12_is_Better_for_Restoring_a_Low_B12_Status_Than_a_Daily_High_Dose_Vitamin_Pill:_An_Experimental_Study_in_Rats_ DB - PRIME DP - Unbound Medicine ER -