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Modulating reconsolidation and extinction to regulate drug reward memory.
Eur J Neurosci. 2019 08; 50(3):2503-2512.EJ

Abstract

Drug addiction is an aberrant memory that shares the same memory processes as other memories. Brief exposure to drug-associated cues could result in reconsolidation, a hypothetical process during which original memory could be updated. In contrast, longer exposure times to drug-associated cues could trigger extinction, a process that decreases the conditioned responding. In this review, we discuss the pharmacological and non-pharmacological manipulations on the reconsolidation and extinction that could be used to interfere with drug reward memories. Pharmacological agents such as β-adrenergic receptor antagonist propranolol can interfere with reconsolidation to disrupt drug reward memory. Pharmacological agents such as the NMDA receptor glycine site agonists d-cycloserine and d-serine can facilitate extinction and then attenuate the expression of drug reward memory. Besides pharmacological interventions, drug-free behavioral approaches by utilizing the reconsolidation and extinction, such as 'post-retrieval extinction' and 'UCS-retrieval extinction', are also effective to erase or inhibit the recall of drug reward memory. Taken together, pharmacological modulation and non-pharmacological modulation of reconsolidation and extinction are promising approaches to regulate drug reward memory and prevent relapse.

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Authors+Show Affiliations

Liu JF
Department of Pharmacology and Toxicology, University at Buffalo, The State University of New York, 955 Main Street, Buffalo, NY, 14203, USA.
Tian J
Department of Pharmacology and Toxicology, University at Buffalo, The State University of New York, 955 Main Street, Buffalo, NY, 14203, USA. School of Pharmacy, Yantai University, Yantai, Shandong Province, China.
Li JX
Department of Pharmacology and Toxicology, University at Buffalo, The State University of New York, 955 Main Street, Buffalo, NY, 14203, USA.

MeSH

Adrenergic beta-AntagonistsAnimalsConditioning, ClassicalExtinction, PsychologicalHumansMemoryMental RecallRewardSubstance-Related Disorders

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

30113098

Citation

Liu, Jian-Feng, et al. "Modulating Reconsolidation and Extinction to Regulate Drug Reward Memory." The European Journal of Neuroscience, vol. 50, no. 3, 2019, pp. 2503-2512.
Liu JF, Tian J, Li JX. Modulating reconsolidation and extinction to regulate drug reward memory. Eur J Neurosci. 2019;50(3):2503-2512.
Liu, J. F., Tian, J., & Li, J. X. (2019). Modulating reconsolidation and extinction to regulate drug reward memory. The European Journal of Neuroscience, 50(3), 2503-2512. https://doi.org/10.1111/ejn.14072
Liu JF, Tian J, Li JX. Modulating Reconsolidation and Extinction to Regulate Drug Reward Memory. Eur J Neurosci. 2019;50(3):2503-2512. PubMed PMID: 30113098.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulating reconsolidation and extinction to regulate drug reward memory. AU - Liu,Jian-Feng, AU - Tian,Jingwei, AU - Li,Jun-Xu, Y1 - 2018/08/16/ PY - 2018/03/17/received PY - 2018/06/20/revised PY - 2018/06/28/accepted PY - 2018/8/17/pubmed PY - 2020/8/8/medline PY - 2018/8/17/entrez KW - drug addiction KW - drug reward memory KW - extinction KW - reconsolidation KW - relapse SP - 2503 EP - 2512 JF - The European journal of neuroscience JO - Eur J Neurosci VL - 50 IS - 3 N2 - Drug addiction is an aberrant memory that shares the same memory processes as other memories. Brief exposure to drug-associated cues could result in reconsolidation, a hypothetical process during which original memory could be updated. In contrast, longer exposure times to drug-associated cues could trigger extinction, a process that decreases the conditioned responding. In this review, we discuss the pharmacological and non-pharmacological manipulations on the reconsolidation and extinction that could be used to interfere with drug reward memories. Pharmacological agents such as β-adrenergic receptor antagonist propranolol can interfere with reconsolidation to disrupt drug reward memory. Pharmacological agents such as the NMDA receptor glycine site agonists d-cycloserine and d-serine can facilitate extinction and then attenuate the expression of drug reward memory. Besides pharmacological interventions, drug-free behavioral approaches by utilizing the reconsolidation and extinction, such as 'post-retrieval extinction' and 'UCS-retrieval extinction', are also effective to erase or inhibit the recall of drug reward memory. Taken together, pharmacological modulation and non-pharmacological modulation of reconsolidation and extinction are promising approaches to regulate drug reward memory and prevent relapse. SN - 1460-9568 UR - https://www.unboundmedicine.com/medline/citation/30113098/Modulating_reconsolidation_and_extinction_to_regulate_drug_reward_memory_ DB - PRIME DP - Unbound Medicine ER -