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Prevalence of restless legs syndrome in individuals with migraine: a systematic review and meta-analysis of observational studies.
Neurol Sci. 2018 Nov; 39(11):1927-1934.NS

Abstract

OBJECTIVE

Recent studies have shown an association between migraine and restless legs syndrome (RLS), but RLS prevalence among individuals with migraine differs substantially across studies. The present work aimed to comprehensively assess available evidence to estimate RLS prevalence among individuals with migraine and non-migraine controls.

METHOD

Web of Science, PubMed, Embase, Chinese National Knowledge Infrastructure, Wanfang, and SinoMed databases were searched for observational and case-control studies of RLS prevalence among individuals with migraine. Eligible studies were meta-analyzed using Stata 12.0 software.

RESULTS

Pooled RLS prevalence in migraine was 19%, and the prevalence was lower in Asia (16%) than outside Asia (21%). Pooled RLS prevalence was 18.8% among individuals with migraine with aura, and 18.5% among individuals with migraine without aura; the RLS prevalence in migraine with aura (MA) was higher than that of migraine without aura (MO) (OR 1.17, 95%CI 1.01-1.34; p = 0.037). Pooled RLS prevalence in a case-control study was significantly higher among individuals with migraine (17.9%) than among non-migraine controls (7.1%) (OR 2.65, 95%CI 2.26-3.10; p < 0.001).

CONCLUSION

Our meta-analysis provides the first reliable pooled estimate of RLS prevalence among individuals with migraine, and it provides strong evidence that RLS risk is higher among individuals with migraine than among controls.

Authors+Show Affiliations

Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan, People's Republic of China.Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan, People's Republic of China.Department of Neurology, The Seventh People's Hospital of Chengdu, Chengdu, 650041, Sichuan, People's Republic of China.Department of Anesthesia, Kunming Xishan District People's Hospital, Kunming, 650100, Yunnan, People's Republic of China.Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan, People's Republic of China.Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan, People's Republic of China.Department of Neurology, West China Hospital, SCU, Chengdu, 650041, Sichuan, People's Republic of China.Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan, People's Republic of China. rh-3338@163.com.Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan, People's Republic of China. xz0702@126.com.

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

30116981

Citation

Yang, Xinglong, et al. "Prevalence of Restless Legs Syndrome in Individuals With Migraine: a Systematic Review and Meta-analysis of Observational Studies." Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, vol. 39, no. 11, 2018, pp. 1927-1934.
Yang X, Liu B, Yang B, et al. Prevalence of restless legs syndrome in individuals with migraine: a systematic review and meta-analysis of observational studies. Neurol Sci. 2018;39(11):1927-1934.
Yang, X., Liu, B., Yang, B., Li, S., Wang, F., Li, K., Hu, F., Ren, H., & Xu, Z. (2018). Prevalence of restless legs syndrome in individuals with migraine: a systematic review and meta-analysis of observational studies. Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 39(11), 1927-1934. https://doi.org/10.1007/s10072-018-3527-7
Yang X, et al. Prevalence of Restless Legs Syndrome in Individuals With Migraine: a Systematic Review and Meta-analysis of Observational Studies. Neurol Sci. 2018;39(11):1927-1934. PubMed PMID: 30116981.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of restless legs syndrome in individuals with migraine: a systematic review and meta-analysis of observational studies. AU - Yang,Xinglong, AU - Liu,Bin, AU - Yang,Baiyuan, AU - Li,Shimei, AU - Wang,Fang, AU - Li,Kelu, AU - Hu,Fayun, AU - Ren,Hui, AU - Xu,Zhong, Y1 - 2018/08/17/ PY - 2018/05/22/received PY - 2018/08/05/accepted PY - 2018/8/18/pubmed PY - 2018/11/18/medline PY - 2018/8/18/entrez KW - Meta-analysis KW - Migraine KW - Prevalence KW - Restless legs syndrome SP - 1927 EP - 1934 JF - Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology JO - Neurol Sci VL - 39 IS - 11 N2 - OBJECTIVE: Recent studies have shown an association between migraine and restless legs syndrome (RLS), but RLS prevalence among individuals with migraine differs substantially across studies. The present work aimed to comprehensively assess available evidence to estimate RLS prevalence among individuals with migraine and non-migraine controls. METHOD: Web of Science, PubMed, Embase, Chinese National Knowledge Infrastructure, Wanfang, and SinoMed databases were searched for observational and case-control studies of RLS prevalence among individuals with migraine. Eligible studies were meta-analyzed using Stata 12.0 software. RESULTS: Pooled RLS prevalence in migraine was 19%, and the prevalence was lower in Asia (16%) than outside Asia (21%). Pooled RLS prevalence was 18.8% among individuals with migraine with aura, and 18.5% among individuals with migraine without aura; the RLS prevalence in migraine with aura (MA) was higher than that of migraine without aura (MO) (OR 1.17, 95%CI 1.01-1.34; p = 0.037). Pooled RLS prevalence in a case-control study was significantly higher among individuals with migraine (17.9%) than among non-migraine controls (7.1%) (OR 2.65, 95%CI 2.26-3.10; p < 0.001). CONCLUSION: Our meta-analysis provides the first reliable pooled estimate of RLS prevalence among individuals with migraine, and it provides strong evidence that RLS risk is higher among individuals with migraine than among controls. SN - 1590-3478 UR - https://www.unboundmedicine.com/medline/citation/30116981/Prevalence_of_restless_legs_syndrome_in_individuals_with_migraine:_a_systematic_review_and_meta_analysis_of_observational_studies_ L2 - https://link.springer.com/10.1007/s10072-018-3527-7 DB - PRIME DP - Unbound Medicine ER -