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Effects of aerobic exercise and vitamin C supplementation on rhinitis symptoms in allergic rhinitis patients.
Asian Pac J Allergy Immunol. 2018 Dec; 36(4):222-231.AP

Abstract

INTRODUCTION

Exercise training and vitamin C supplementation have both been recommended as an effective adjuvant treatment in the management of symptoms in patients with many diseases. However, its effects on rhinitis symptoms remain unclear. The aim of the present study was to determine the effects of exercise training alone, and in combination with vitamin C supplementation, on rhinitis symptoms in allergic rhinitis patients.

METHODS

Twenty-seven rhinitis patients were randomized into 3 groups: control (CON; n = 8), exercise (EX; n = 9), and exercise combined with vitamin C (EX + Vit.C; n = 10). The exercise training protocol consisted of walking and/or running on a treadmill at 65-70% heart rate reserve for 30 min per session, 3 times per week for 8 weeks. The EX + Vit.C group ingested 2,000 mg vitamin C per day.

RESULTS

After 8 weeks, both EX and EX + Vit.C groups increased peak aerobic capacity and peak nasal inspiratory flow (PNIF) and exhibited significantly decreased rhinitis symptoms, nasal blood flow (NBF) and malondialdehylde levels compared to pre-test. Rhinitis symptoms and NBF after nasal challenge with house dust mite decreased significantly in the EX and EX + Vit.C groups. The EX and EX + Vit.C groups had significantly lower nasal secretion interleukin (IL)-4, but higher nasal secretion IL-2 levels, than the CON group.

CONCLUSIONS

This study clearly confirms that aerobic exercise training significantly improved clinical of allergic rhinitis and cytokine profiles. Nonetheless, with the limited power of small sample size, whether adding vitamin C is any beneficial is not shown. A larger randomized controlled trial is thus warranted.

Authors+Show Affiliations

Faculty of Sports Science, Chulalongkorn University, Bangkok, Thailand.Division of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine, Allergy and Clinical Immunology Research Group, Chulalongkorn University, Bangkok, Thailand.Department of Kinesiology, School of Public Health, Indiana University, Bloomington, Indiana, USA.Faculty of Sports Science, Chulalongkorn University, Bangkok, Thailand.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

30118241

Citation

Tongtako, Wannaporn, et al. "Effects of Aerobic Exercise and Vitamin C Supplementation On Rhinitis Symptoms in Allergic Rhinitis Patients." Asian Pacific Journal of Allergy and Immunology, vol. 36, no. 4, 2018, pp. 222-231.
Tongtako W, Klaewsongkram J, Mickleborough TD, et al. Effects of aerobic exercise and vitamin C supplementation on rhinitis symptoms in allergic rhinitis patients. Asian Pac J Allergy Immunol. 2018;36(4):222-231.
Tongtako, W., Klaewsongkram, J., Mickleborough, T. D., & Suksom, D. (2018). Effects of aerobic exercise and vitamin C supplementation on rhinitis symptoms in allergic rhinitis patients. Asian Pacific Journal of Allergy and Immunology, 36(4), 222-231. https://doi.org/10.12932/AP-040417-0066
Tongtako W, et al. Effects of Aerobic Exercise and Vitamin C Supplementation On Rhinitis Symptoms in Allergic Rhinitis Patients. Asian Pac J Allergy Immunol. 2018;36(4):222-231. PubMed PMID: 30118241.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of aerobic exercise and vitamin C supplementation on rhinitis symptoms in allergic rhinitis patients. AU - Tongtako,Wannaporn, AU - Klaewsongkram,Jettanong, AU - Mickleborough,Timothy D, AU - Suksom,Daroonwan, PY - 2018/8/18/pubmed PY - 2020/6/18/medline PY - 2018/8/18/entrez SP - 222 EP - 231 JF - Asian Pacific journal of allergy and immunology JO - Asian Pac. J. Allergy Immunol. VL - 36 IS - 4 N2 - INTRODUCTION: Exercise training and vitamin C supplementation have both been recommended as an effective adjuvant treatment in the management of symptoms in patients with many diseases. However, its effects on rhinitis symptoms remain unclear. The aim of the present study was to determine the effects of exercise training alone, and in combination with vitamin C supplementation, on rhinitis symptoms in allergic rhinitis patients. METHODS: Twenty-seven rhinitis patients were randomized into 3 groups: control (CON; n = 8), exercise (EX; n = 9), and exercise combined with vitamin C (EX + Vit.C; n = 10). The exercise training protocol consisted of walking and/or running on a treadmill at 65-70% heart rate reserve for 30 min per session, 3 times per week for 8 weeks. The EX + Vit.C group ingested 2,000 mg vitamin C per day. RESULTS: After 8 weeks, both EX and EX + Vit.C groups increased peak aerobic capacity and peak nasal inspiratory flow (PNIF) and exhibited significantly decreased rhinitis symptoms, nasal blood flow (NBF) and malondialdehylde levels compared to pre-test. Rhinitis symptoms and NBF after nasal challenge with house dust mite decreased significantly in the EX and EX + Vit.C groups. The EX and EX + Vit.C groups had significantly lower nasal secretion interleukin (IL)-4, but higher nasal secretion IL-2 levels, than the CON group. CONCLUSIONS: This study clearly confirms that aerobic exercise training significantly improved clinical of allergic rhinitis and cytokine profiles. Nonetheless, with the limited power of small sample size, whether adding vitamin C is any beneficial is not shown. A larger randomized controlled trial is thus warranted. SN - 0125-877X UR - https://www.unboundmedicine.com/medline/citation/30118241/Effects_of_aerobic_exercise_and_vitamin_C_supplementation_on_rhinitis_symptoms_in_allergic_rhinitis_patients_ L2 - http://apjai-journal.org/wp-content/uploads/2019/01/3EffectsAPJAIVol36No4December2018P.pdf DB - PRIME DP - Unbound Medicine ER -