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Reduction of cisplatin-induced renal and hepatic side effects in rat through antioxidative and anti-inflammatory properties of Malva sylvestris L. extract.
Biomed Pharmacother. 2018 Oct; 106:1767-1774.BP

Abstract

BACKGROUND

Cisplatin is widely used in the chemotherapy of solid organ cancers. However, its application is associated with serious side effects in various organs including the kidneys and liver.

OBJECTIVES

The aim of this study was to investigate the effects of mallow extract on the side effects of cisplatin in the kidneys and liver.

METHODS

Hydroalcoholic extract of mallow, at doses of 200, 400, and 600 mg/kg BW, was administered to the animals for seven days intraperitoneally (ip). Animals in the Cis + Mallow group received a dose of cisplatin (8 mg/kg, ip) on the third day. Renal and hepatic functional disturbances were evaluated by measuring concentrations of creatinine, urea-nitrogen, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in the plasma. In order to assess oxidative stress, malondialdehyde (MDA) and ferric reducing antioxidant power (FRAP) levels were measured in the kidney tissue. Then, degree of mRNA expressions of TNF-α and ICAM-1 were measured to examine renal inflammation. Hematoxylin and Eosin (H & E) staining of kidney and liver tissues was performed to study tissue damage and leukocyte infiltration.

RESULTS

Cisplatin increased levels of plasma creatinine, urea-nitrogen, AST, and ALT; levels of tissue damage and leukocytes infiltration in the kidneys and liver; and MDA level and expression of pro-inflammatory factors in the kidney tissue. Meanwhile, it decreased FRAP level in the kidney tissue. Pretreatment by mallow extract resulted in significant improvement in all measured variables although 200-mg and 400-mg doses yielded better results.

CONCLUSION

Results showed that mallow supplement protects the kidneys and liver against side effects of cisplatin, and reduces the resultant oxidative stress and inflammation.

Authors+Show Affiliations

Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.Department of Pathology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address: houshang.najafi@gmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30119252

Citation

Mohamadi Yarijani, Zeynab, et al. "Reduction of Cisplatin-induced Renal and Hepatic Side Effects in Rat Through Antioxidative and Anti-inflammatory Properties of Malva Sylvestris L. Extract." Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, vol. 106, 2018, pp. 1767-1774.
Mohamadi Yarijani Z, Godini A, Madani SH, et al. Reduction of cisplatin-induced renal and hepatic side effects in rat through antioxidative and anti-inflammatory properties of Malva sylvestris L. extract. Biomed Pharmacother. 2018;106:1767-1774.
Mohamadi Yarijani, Z., Godini, A., Madani, S. H., & Najafi, H. (2018). Reduction of cisplatin-induced renal and hepatic side effects in rat through antioxidative and anti-inflammatory properties of Malva sylvestris L. extract. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 106, 1767-1774. https://doi.org/10.1016/j.biopha.2018.07.115
Mohamadi Yarijani Z, et al. Reduction of Cisplatin-induced Renal and Hepatic Side Effects in Rat Through Antioxidative and Anti-inflammatory Properties of Malva Sylvestris L. Extract. Biomed Pharmacother. 2018;106:1767-1774. PubMed PMID: 30119252.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduction of cisplatin-induced renal and hepatic side effects in rat through antioxidative and anti-inflammatory properties of Malva sylvestris L. extract. AU - Mohamadi Yarijani,Zeynab, AU - Godini,Aliashraf, AU - Madani,Seyed Hamid, AU - Najafi,Houshang, Y1 - 2018/07/31/ PY - 2018/06/10/received PY - 2018/07/23/revised PY - 2018/07/24/accepted PY - 2018/8/19/pubmed PY - 2018/12/12/medline PY - 2018/8/19/entrez KW - Cisplatin KW - Inflammation KW - Malva sylvestris KW - Nephrotoxicity KW - Oxidative stress SP - 1767 EP - 1774 JF - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie JO - Biomed Pharmacother VL - 106 N2 - BACKGROUND: Cisplatin is widely used in the chemotherapy of solid organ cancers. However, its application is associated with serious side effects in various organs including the kidneys and liver. OBJECTIVES: The aim of this study was to investigate the effects of mallow extract on the side effects of cisplatin in the kidneys and liver. METHODS: Hydroalcoholic extract of mallow, at doses of 200, 400, and 600 mg/kg BW, was administered to the animals for seven days intraperitoneally (ip). Animals in the Cis + Mallow group received a dose of cisplatin (8 mg/kg, ip) on the third day. Renal and hepatic functional disturbances were evaluated by measuring concentrations of creatinine, urea-nitrogen, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in the plasma. In order to assess oxidative stress, malondialdehyde (MDA) and ferric reducing antioxidant power (FRAP) levels were measured in the kidney tissue. Then, degree of mRNA expressions of TNF-α and ICAM-1 were measured to examine renal inflammation. Hematoxylin and Eosin (H & E) staining of kidney and liver tissues was performed to study tissue damage and leukocyte infiltration. RESULTS: Cisplatin increased levels of plasma creatinine, urea-nitrogen, AST, and ALT; levels of tissue damage and leukocytes infiltration in the kidneys and liver; and MDA level and expression of pro-inflammatory factors in the kidney tissue. Meanwhile, it decreased FRAP level in the kidney tissue. Pretreatment by mallow extract resulted in significant improvement in all measured variables although 200-mg and 400-mg doses yielded better results. CONCLUSION: Results showed that mallow supplement protects the kidneys and liver against side effects of cisplatin, and reduces the resultant oxidative stress and inflammation. SN - 1950-6007 UR - https://www.unboundmedicine.com/medline/citation/30119252/Reduction_of_cisplatin_induced_renal_and_hepatic_side_effects_in_rat_through_antioxidative_and_anti_inflammatory_properties_of_Malva_sylvestris_L__extract_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0753-3322(18)33941-6 DB - PRIME DP - Unbound Medicine ER -