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Evaluation of in vitro antioxidant, antiglycation and antimicrobial potential of indigenous Myanmar medicinal plants.
J Integr Med. 2018 09; 16(5):358-366.JI

Abstract

OBJECTIVE

Myanmar has a long history of using medicinal plants for treatment of various diseases. To the best of our knowledge there are no previous reports on antiglycation activities of medicinal plants from Myanmar. Therefore, this study was aimed to evaluate the antioxidant, antiglycation and antimicrobial properties of 20 ethanolic extracts from 17 medicinal plants indigenous to Myanmar.

METHODS

In vitro scavenging assays of 2,2-diphenyl-1-picrylhydrazyl (DPPH), nitric oxide (NO), superoxide (SO) radicals were used to determine the antioxidant activities. Folin-Ciocalteu's method was performed to determine the total phenolic content. Antiglycation and antimicrobial activities were detected by bovine serum albumin-fluorescent assay and agar well diffusion method.

RESULTS

Terminalia chebula Retz. (Fruit), containing the highest total phenolic content, showed high antioxidant activities with inhibition of 77.98% ± 0.92%, 88.95% ± 2.42%, 88.56% ± 1.87% and 70.74%± 2.57% for DPPH, NO, SO assays and antiglycation activity respectively. It also showed the antimicrobial activities against Staphylococcus aureus, Bacillus cereus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans with inhibition zone of 19, 18, 17, 25 and 15 mm, respectively. Garcinia mangostana Linn. showed the strongest activities for SO and antiglycation assays with inhibition of 93.68% ± 2.63% and 82.37% ± 1.78%. Bark of Melia sp. was the best NO radical scavenger with inhibition rate of 89.39%± 0.60%.

CONCLUSION

The results suggest that these plants are potential sources of antioxidants with free radical-scavenging and antiglycation activities and could be useful for decreasing the oxidative stress and glycation end-product formation in glycation-related diseases.

Authors+Show Affiliations

Pharmaceutical Research Laboratory, Biotechnology Research Department, Ministry of Education, Mandalay Division, Kyaukse 05151, Myanmar. Electronic address: thesumoe@gmail.com.Pharmaceutical Research Laboratory, Biotechnology Research Department, Ministry of Education, Mandalay Division, Kyaukse 05151, Myanmar.Department of Research and Innovation (DRI), Ministry of Education, Yangon 11081, Myanmar.Pharmaceutical Research Laboratory, Biotechnology Research Department, Ministry of Education, Mandalay Division, Kyaukse 05151, Myanmar.Pharmaceutical Research Laboratory, Biotechnology Research Department, Ministry of Education, Mandalay Division, Kyaukse 05151, Myanmar.Cell Culture Laboratory, Biotechnology Research Department, Ministry of Education, Mandalay Division, Kyaukse 05151, Myanmar.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30120077

Citation

Moe, The Su, et al. "Evaluation of in Vitro Antioxidant, Antiglycation and Antimicrobial Potential of Indigenous Myanmar Medicinal Plants." Journal of Integrative Medicine, vol. 16, no. 5, 2018, pp. 358-366.
Moe TS, Win HH, Hlaing TT, et al. Evaluation of in vitro antioxidant, antiglycation and antimicrobial potential of indigenous Myanmar medicinal plants. J Integr Med. 2018;16(5):358-366.
Moe, T. S., Win, H. H., Hlaing, T. T., Lwin, W. W., Htet, Z. M., & Mya, K. M. (2018). Evaluation of in vitro antioxidant, antiglycation and antimicrobial potential of indigenous Myanmar medicinal plants. Journal of Integrative Medicine, 16(5), 358-366. https://doi.org/10.1016/j.joim.2018.08.001
Moe TS, et al. Evaluation of in Vitro Antioxidant, Antiglycation and Antimicrobial Potential of Indigenous Myanmar Medicinal Plants. J Integr Med. 2018;16(5):358-366. PubMed PMID: 30120077.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of in vitro antioxidant, antiglycation and antimicrobial potential of indigenous Myanmar medicinal plants. AU - Moe,The Su, AU - Win,Htet Htet, AU - Hlaing,Thin Thin, AU - Lwin,War War, AU - Htet,Zaw Min, AU - Mya,Khin Mar, Y1 - 2018/08/04/ PY - 2018/02/02/received PY - 2018/06/08/accepted PY - 2018/8/19/pubmed PY - 2018/12/18/medline PY - 2018/8/19/entrez KW - 2,2-Diphenyl-1-picrylhydrazyl KW - Antiglycation KW - Antimicrobial agents KW - Antioxidant KW - Medicinal plants KW - Nitric oxide KW - Superoxide SP - 358 EP - 366 JF - Journal of integrative medicine JO - J Integr Med VL - 16 IS - 5 N2 - OBJECTIVE: Myanmar has a long history of using medicinal plants for treatment of various diseases. To the best of our knowledge there are no previous reports on antiglycation activities of medicinal plants from Myanmar. Therefore, this study was aimed to evaluate the antioxidant, antiglycation and antimicrobial properties of 20 ethanolic extracts from 17 medicinal plants indigenous to Myanmar. METHODS: In vitro scavenging assays of 2,2-diphenyl-1-picrylhydrazyl (DPPH), nitric oxide (NO), superoxide (SO) radicals were used to determine the antioxidant activities. Folin-Ciocalteu's method was performed to determine the total phenolic content. Antiglycation and antimicrobial activities were detected by bovine serum albumin-fluorescent assay and agar well diffusion method. RESULTS: Terminalia chebula Retz. (Fruit), containing the highest total phenolic content, showed high antioxidant activities with inhibition of 77.98% ± 0.92%, 88.95% ± 2.42%, 88.56% ± 1.87% and 70.74%± 2.57% for DPPH, NO, SO assays and antiglycation activity respectively. It also showed the antimicrobial activities against Staphylococcus aureus, Bacillus cereus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans with inhibition zone of 19, 18, 17, 25 and 15 mm, respectively. Garcinia mangostana Linn. showed the strongest activities for SO and antiglycation assays with inhibition of 93.68% ± 2.63% and 82.37% ± 1.78%. Bark of Melia sp. was the best NO radical scavenger with inhibition rate of 89.39%± 0.60%. CONCLUSION: The results suggest that these plants are potential sources of antioxidants with free radical-scavenging and antiglycation activities and could be useful for decreasing the oxidative stress and glycation end-product formation in glycation-related diseases. SN - 2095-4964 UR - https://www.unboundmedicine.com/medline/citation/30120077/Evaluation_of_in_vitro_antioxidant_antiglycation_and_antimicrobial_potential_of_indigenous_Myanmar_medicinal_plants_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2095-4964(18)30083-9 DB - PRIME DP - Unbound Medicine ER -