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Evaluation of optic nerve head changes with optic coherence tomography in patients with idiopathic intracranial hypertension.
Acta Neurol Belg. 2019 Sep; 119(3):351-357.AN

Abstract

In the case of mild papilledema, fundoscopy findings may sometimes be insufficient, leading to false and misleading indices in the diagnosis of early-stage idiopathic intracranial hypertension (IIH). This study aims to evaluate these patients through optic coherence tomography (OCT). The study included 54 individuals diagnosed with IIH and 48 healthy individuals in the control group. All patients underwent neurological and ophthalmologic examinations. Opening pressure values of patients' cerebrospinal fluid (CSF) were recorded. We measured the thickness of the retinal nerve fiber layer (RNFL) and the ganglion cell complex, cup volume, and the optical disc area, as well as the neuroretinal rim in both groups. A total of 108 eyes from the patient group and 96 eyes from the control group were evaluated. It was found that the mean value of the RNFL thickness of the IIH patients was greater than the control group in the following eight segments: superior nasal, superior temporal, inferior nasal, inferior temporal, nasal superior, nasal inferior, temporal superior, and temporal inferior (p < 0.01 for all). In contrast to the control group, the disc and rim area values of the patient group were higher (p < 0.01), while the cup volume was smaller (p < 0.01) than in the control group. In the patient group, a positive correlation was observed between the papilledema grade and the RNFL thickness (r = 0.64, p < 0.01), CSF opening pressure (r = 0.59, p < 0.01), disc area (r = 0.68, p < 0.01), and rim area (r = 0.70, p < 0.01). Furthermore, RNFL thickness, CSF opening pressure (r = 0.61, p < 0.01), disc area (r = 0.71, p < 0.01), and rim area (r = 0.71, p < 0.01) values were determined to be positively correlated to each other. OCT is believed to contribute to the diagnosis of IIH, by providing reliable data on optical cup volume, optical disc and rim area, and a greater RNFL thickness.

Authors+Show Affiliations

Neurology Clinic of Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey. yeren.72@hotmail.com.Opthalmology Clinic of Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.Neurology Clinic of Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.Neurology Clinic of Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.Opthalmology Clinic of Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30120685

Citation

Eren, Yasemin, et al. "Evaluation of Optic Nerve Head Changes With Optic Coherence Tomography in Patients With Idiopathic Intracranial Hypertension." Acta Neurologica Belgica, vol. 119, no. 3, 2019, pp. 351-357.
Eren Y, Kabatas N, Guven H, et al. Evaluation of optic nerve head changes with optic coherence tomography in patients with idiopathic intracranial hypertension. Acta Neurol Belg. 2019;119(3):351-357.
Eren, Y., Kabatas, N., Guven, H., Comoglu, S., & Gurdal, C. (2019). Evaluation of optic nerve head changes with optic coherence tomography in patients with idiopathic intracranial hypertension. Acta Neurologica Belgica, 119(3), 351-357. https://doi.org/10.1007/s13760-018-1000-2
Eren Y, et al. Evaluation of Optic Nerve Head Changes With Optic Coherence Tomography in Patients With Idiopathic Intracranial Hypertension. Acta Neurol Belg. 2019;119(3):351-357. PubMed PMID: 30120685.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of optic nerve head changes with optic coherence tomography in patients with idiopathic intracranial hypertension. AU - Eren,Yasemin, AU - Kabatas,Naciye, AU - Guven,Hayat, AU - Comoglu,Selcuk, AU - Gurdal,Canan, Y1 - 2018/08/17/ PY - 2018/01/09/received PY - 2018/08/13/accepted PY - 2018/8/19/pubmed PY - 2020/2/13/medline PY - 2018/8/19/entrez KW - Disc area KW - Idiopathic intracranial hypertension KW - OCT KW - RNLF SP - 351 EP - 357 JF - Acta neurologica Belgica JO - Acta Neurol Belg VL - 119 IS - 3 N2 - In the case of mild papilledema, fundoscopy findings may sometimes be insufficient, leading to false and misleading indices in the diagnosis of early-stage idiopathic intracranial hypertension (IIH). This study aims to evaluate these patients through optic coherence tomography (OCT). The study included 54 individuals diagnosed with IIH and 48 healthy individuals in the control group. All patients underwent neurological and ophthalmologic examinations. Opening pressure values of patients' cerebrospinal fluid (CSF) were recorded. We measured the thickness of the retinal nerve fiber layer (RNFL) and the ganglion cell complex, cup volume, and the optical disc area, as well as the neuroretinal rim in both groups. A total of 108 eyes from the patient group and 96 eyes from the control group were evaluated. It was found that the mean value of the RNFL thickness of the IIH patients was greater than the control group in the following eight segments: superior nasal, superior temporal, inferior nasal, inferior temporal, nasal superior, nasal inferior, temporal superior, and temporal inferior (p < 0.01 for all). In contrast to the control group, the disc and rim area values of the patient group were higher (p < 0.01), while the cup volume was smaller (p < 0.01) than in the control group. In the patient group, a positive correlation was observed between the papilledema grade and the RNFL thickness (r = 0.64, p < 0.01), CSF opening pressure (r = 0.59, p < 0.01), disc area (r = 0.68, p < 0.01), and rim area (r = 0.70, p < 0.01). Furthermore, RNFL thickness, CSF opening pressure (r = 0.61, p < 0.01), disc area (r = 0.71, p < 0.01), and rim area (r = 0.71, p < 0.01) values were determined to be positively correlated to each other. OCT is believed to contribute to the diagnosis of IIH, by providing reliable data on optical cup volume, optical disc and rim area, and a greater RNFL thickness. SN - 2240-2993 UR - https://www.unboundmedicine.com/medline/citation/30120685/Evaluation_of_optic_nerve_head_changes_with_optic_coherence_tomography_in_patients_with_idiopathic_intracranial_hypertension_ L2 - https://dx.doi.org/10.1007/s13760-018-1000-2 DB - PRIME DP - Unbound Medicine ER -