Tags

Type your tag names separated by a space and hit enter

Effects of CYP2R1 gene variants on vitamin D levels and status: A systematic review and meta-analysis.
Gene. 2018 Dec 15; 678:361-369.GENE

Abstract

BACKGROUND AND OBJECTIVE

CYP2R1 is a key gene in the vitamin D metabolic pathway. It has been suggested that CYP2R1 gene variants in European populations are associated with concentrations of 25(OH)D, a biomarker of vitamin D levels and status in peripheral blood. However, a comprehensive meta-analysis of this effect including different ethnicities has never been conducted. The objective of this meta-analysis was to evaluate the association between CYP2R1 gene variants and 25(OH)D levels and vitamin D status.

METHODS

PubMed, EMBASE, Web of Science, CNKI and Wanfang databases were systematically searched up to May 2018. Reporting followed PRISMA guidelines. The quality of the evidence was assessed using the STREGA system. Random or fixed effects model combined estimates and sub-group tested for ethnic differences. The I2 statistic quantified between-study variation due to heterogeneity.

RESULTS

Sixteen articles with a total of 52,417 participants met the inclusion criteria and were included in the meta-analysis. For rs10741657, GG genotype was associated with a clear descending trend of 25(OH)D levels when compared with the AA genotype [SMD = -2.32, 95% CI (-4.42, -0.20); SMD = -3.46, 95% CI (-6.60, -0.33) and SMD = -0.24, 95% CI (-0.51, -0.03) for total, Caucasian and Asian groups, respectively] with the following heterogeneities I2 = 37.9%, 69.2% and 24.5%, respectively. However, under the AG/AA genetic model, significant changes in 25(OH)D levels [SMD and 95% CI: -1.27(-2.32, -0.23)] were only evident in the Caucasian population. The meta-analysis on vitamin D deficiency showed that the risk-allele G was associated with an increased risk of vitamin D deficiency (OR = 1.09; 95% CI = 1.03-1.15, P = 0.002). The association between rs10741657 and increased risk of vitamin D deficiency was significant (OR = 1.42; 95% CI = 1.11-1.83, P = 0.006) under the dominant model (GG + AG/AA), but not under the recessive model (GG/AG + AA), (OR = 1.28; 95% CI = 0.89-1.84, P = 0.181). There was no evidence of publication bias.

CONCLUSION

Published articles provide evidence supporting a major role for the rs10741657 polymorphism of the CYP2R1 gene in determining 25(OH)D levels and the presence of vitamin D deficiency.

Authors+Show Affiliations

Department of Medical Services, Zhengzhou Central Hospital affiliated to Zhengzhou University, Zhengzhou 450001, China.Department of Medical Services, Zhengzhou Central Hospital affiliated to Zhengzhou University, Zhengzhou 450001, China.Department of Medical Services, Zhengzhou Central Hospital affiliated to Zhengzhou University, Zhengzhou 450001, China.Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou 450001, China.Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou 450001, China. Electronic address: doctorwangxiaoy@163.com.

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

30120973

Citation

Duan, Leizhen, et al. "Effects of CYP2R1 Gene Variants On Vitamin D Levels and Status: a Systematic Review and Meta-analysis." Gene, vol. 678, 2018, pp. 361-369.
Duan L, Xue Z, Ji H, et al. Effects of CYP2R1 gene variants on vitamin D levels and status: A systematic review and meta-analysis. Gene. 2018;678:361-369.
Duan, L., Xue, Z., Ji, H., Zhang, D., & Wang, Y. (2018). Effects of CYP2R1 gene variants on vitamin D levels and status: A systematic review and meta-analysis. Gene, 678, 361-369. https://doi.org/10.1016/j.gene.2018.08.056
Duan L, et al. Effects of CYP2R1 Gene Variants On Vitamin D Levels and Status: a Systematic Review and Meta-analysis. Gene. 2018 Dec 15;678:361-369. PubMed PMID: 30120973.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of CYP2R1 gene variants on vitamin D levels and status: A systematic review and meta-analysis. AU - Duan,Leizhen, AU - Xue,Zonggui, AU - Ji,Huanwen, AU - Zhang,Dongdong, AU - Wang,Yan, Y1 - 2018/08/16/ PY - 2018/06/05/received PY - 2018/08/13/revised PY - 2018/08/14/accepted PY - 2018/8/19/pubmed PY - 2018/10/23/medline PY - 2018/8/19/entrez KW - 25(OH)D KW - CYP2R1 KW - Meta-analysis KW - Polymorphism KW - Vitamin D deficiency SP - 361 EP - 369 JF - Gene JO - Gene VL - 678 N2 - BACKGROUND AND OBJECTIVE: CYP2R1 is a key gene in the vitamin D metabolic pathway. It has been suggested that CYP2R1 gene variants in European populations are associated with concentrations of 25(OH)D, a biomarker of vitamin D levels and status in peripheral blood. However, a comprehensive meta-analysis of this effect including different ethnicities has never been conducted. The objective of this meta-analysis was to evaluate the association between CYP2R1 gene variants and 25(OH)D levels and vitamin D status. METHODS: PubMed, EMBASE, Web of Science, CNKI and Wanfang databases were systematically searched up to May 2018. Reporting followed PRISMA guidelines. The quality of the evidence was assessed using the STREGA system. Random or fixed effects model combined estimates and sub-group tested for ethnic differences. The I2 statistic quantified between-study variation due to heterogeneity. RESULTS: Sixteen articles with a total of 52,417 participants met the inclusion criteria and were included in the meta-analysis. For rs10741657, GG genotype was associated with a clear descending trend of 25(OH)D levels when compared with the AA genotype [SMD = -2.32, 95% CI (-4.42, -0.20); SMD = -3.46, 95% CI (-6.60, -0.33) and SMD = -0.24, 95% CI (-0.51, -0.03) for total, Caucasian and Asian groups, respectively] with the following heterogeneities I2 = 37.9%, 69.2% and 24.5%, respectively. However, under the AG/AA genetic model, significant changes in 25(OH)D levels [SMD and 95% CI: -1.27(-2.32, -0.23)] were only evident in the Caucasian population. The meta-analysis on vitamin D deficiency showed that the risk-allele G was associated with an increased risk of vitamin D deficiency (OR = 1.09; 95% CI = 1.03-1.15, P = 0.002). The association between rs10741657 and increased risk of vitamin D deficiency was significant (OR = 1.42; 95% CI = 1.11-1.83, P = 0.006) under the dominant model (GG + AG/AA), but not under the recessive model (GG/AG + AA), (OR = 1.28; 95% CI = 0.89-1.84, P = 0.181). There was no evidence of publication bias. CONCLUSION: Published articles provide evidence supporting a major role for the rs10741657 polymorphism of the CYP2R1 gene in determining 25(OH)D levels and the presence of vitamin D deficiency. SN - 1879-0038 UR - https://www.unboundmedicine.com/medline/citation/30120973/Effects_of_CYP2R1_gene_variants_on_vitamin_D_levels_and_status:_A_systematic_review_and_meta_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-1119(18)30918-1 DB - PRIME DP - Unbound Medicine ER -