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Exposure to air pollution during preconceptional and prenatal periods and risk of hypertensive disorders of pregnancy: a retrospective cohort study in Seoul, Korea.
BMC Pregnancy Childbirth. 2018 Aug 22; 18(1):340.BP

Abstract

BACKGROUND

Previous studies suggested associations between prenatal exposure to air pollution and hypertensive disorders of pregnancy. We explored the associations between ambient concentrations of five major air pollutants during preconceptional and prenatal periods and three hypertensive disorders of pregnancy in Seoul, Korea, using a population-representative cohort.

METHODS

We obtained heath and demographic data of pregnant women residing in Seoul for 2002-2013 from the Korean National Health Insurance Service-National Sample Cohort. For mother's individual exposures to air pollution, we computed concentrations of particulate matter ≤10 μm in diameter (PM10), nitrogen dioxide (NO2), carbon monoxide (CO), sulfur dioxide (SO2), and ozone (O3) during 1, 3, 6, and 12 months to birth using regulatory monitoring data in Seoul. The associations between air pollution and hypertensive disorders were explored by using logistic regression models after adjusting for individual confounders.

RESULTS

Among 18,835 pregnant women in Seoul, 0.6, 0.5, and 0.4% of women developed gestational hypertension, preeclampsia, and preeclampsia requiring magnesium sulfate (Mg-preeclampsia), respectively. Although most odds ratios (ORs) were not statistically significant, we found increasing risk gradients with disease severity depending on the pollutant. There was the association between PM10 during 6 months to birth and gestational hypertension (OR for an interquartile range increase = 1.68 [95% confidence interval = 1.09-2.58]). NO2 and ozone during 12 and 1 month, respectively, before birth were associated with Mg-preeclampsia (1.43 [1.01-2.03], 1.53 [1.03-2.27]).

CONCLUSIONS

We observed positive associations of exposure to some air pollutants before and during pregnancy with hypertensive disorders of pregnancy among the Korean general population. Future studies with refined exposure metrics should confirm our findings.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, School of Medicine, CHA University, Gyeonggi-do, Seongnam, 13488, South Korea. Department of Epidemiology, Brown University School of Public Health, Providence, 02903, RI, USA.Department of Statistics, Seoul National University, Seoul, 08826, South Korea.Department of Cancer Control and Population Health, Graduate School of Cancer Science and Policy, National Cancer Center, Gyeonggi-do, Goyang, 10408, South Korea. sykim@ncc.re.kr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30134853

Citation

Choe, Seung-Ah, et al. "Exposure to Air Pollution During Preconceptional and Prenatal Periods and Risk of Hypertensive Disorders of Pregnancy: a Retrospective Cohort Study in Seoul, Korea." BMC Pregnancy and Childbirth, vol. 18, no. 1, 2018, p. 340.
Choe SA, Jun YB, Kim SY. Exposure to air pollution during preconceptional and prenatal periods and risk of hypertensive disorders of pregnancy: a retrospective cohort study in Seoul, Korea. BMC Pregnancy Childbirth. 2018;18(1):340.
Choe, S. A., Jun, Y. B., & Kim, S. Y. (2018). Exposure to air pollution during preconceptional and prenatal periods and risk of hypertensive disorders of pregnancy: a retrospective cohort study in Seoul, Korea. BMC Pregnancy and Childbirth, 18(1), 340. https://doi.org/10.1186/s12884-018-1982-z
Choe SA, Jun YB, Kim SY. Exposure to Air Pollution During Preconceptional and Prenatal Periods and Risk of Hypertensive Disorders of Pregnancy: a Retrospective Cohort Study in Seoul, Korea. BMC Pregnancy Childbirth. 2018 Aug 22;18(1):340. PubMed PMID: 30134853.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exposure to air pollution during preconceptional and prenatal periods and risk of hypertensive disorders of pregnancy: a retrospective cohort study in Seoul, Korea. AU - Choe,Seung-Ah, AU - Jun,Yoon-Bae, AU - Kim,Sun-Young, Y1 - 2018/08/22/ PY - 2017/04/05/received PY - 2018/08/15/accepted PY - 2018/8/24/entrez PY - 2018/8/24/pubmed PY - 2018/12/12/medline KW - Air pollution KW - Cohort KW - Gestational hypertension KW - Preconceptional exposure KW - Preeclampsia SP - 340 EP - 340 JF - BMC pregnancy and childbirth JO - BMC Pregnancy Childbirth VL - 18 IS - 1 N2 - BACKGROUND: Previous studies suggested associations between prenatal exposure to air pollution and hypertensive disorders of pregnancy. We explored the associations between ambient concentrations of five major air pollutants during preconceptional and prenatal periods and three hypertensive disorders of pregnancy in Seoul, Korea, using a population-representative cohort. METHODS: We obtained heath and demographic data of pregnant women residing in Seoul for 2002-2013 from the Korean National Health Insurance Service-National Sample Cohort. For mother's individual exposures to air pollution, we computed concentrations of particulate matter ≤10 μm in diameter (PM10), nitrogen dioxide (NO2), carbon monoxide (CO), sulfur dioxide (SO2), and ozone (O3) during 1, 3, 6, and 12 months to birth using regulatory monitoring data in Seoul. The associations between air pollution and hypertensive disorders were explored by using logistic regression models after adjusting for individual confounders. RESULTS: Among 18,835 pregnant women in Seoul, 0.6, 0.5, and 0.4% of women developed gestational hypertension, preeclampsia, and preeclampsia requiring magnesium sulfate (Mg-preeclampsia), respectively. Although most odds ratios (ORs) were not statistically significant, we found increasing risk gradients with disease severity depending on the pollutant. There was the association between PM10 during 6 months to birth and gestational hypertension (OR for an interquartile range increase = 1.68 [95% confidence interval = 1.09-2.58]). NO2 and ozone during 12 and 1 month, respectively, before birth were associated with Mg-preeclampsia (1.43 [1.01-2.03], 1.53 [1.03-2.27]). CONCLUSIONS: We observed positive associations of exposure to some air pollutants before and during pregnancy with hypertensive disorders of pregnancy among the Korean general population. Future studies with refined exposure metrics should confirm our findings. SN - 1471-2393 UR - https://www.unboundmedicine.com/medline/citation/30134853/Exposure_to_air_pollution_during_preconceptional_and_prenatal_periods_and_risk_of_hypertensive_disorders_of_pregnancy:_a_retrospective_cohort_study_in_Seoul_Korea_ L2 - https://bmcpregnancychildbirth.biomedcentral.com/articles/10.1186/s12884-018-1982-z DB - PRIME DP - Unbound Medicine ER -