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In Vivo Determination of Moisturizers Efficacy on Human Skin Hydration by Confocal Raman Spectroscopy.
AAPS PharmSciTech. 2018 Oct; 19(7):3177-3186.AP

Abstract

This research work deals with in vivo testing of the efficacy of commercial moisturizer products on the hydration of human skin, as there are various in vitro and ex vivo studies questioning their activity. Confocal Raman spectroscopy was used for this purpose of assessing the efficacy of moisturizers on skin hydration mainly owing to its simple, non-invasive, non-destructive, timesaving, and cost-effective nature. Water content and natural moisturizing factor (NMF) of stratum corneum were analyzed and compared using this method at high wavenumber (2500-4000 cm-1) and fingerprint (400-1800 cm-1) spectral regions, respectively, as these two parameters are correlated to skin hydration. Four commercial moisturizer products of different brands were tested on volar forearm region of healthy human female volunteers. This study was conducted for a period of 30 days with 0, 7, and 30 days as time points of analysis. The results of this study clearly indicate that not all the moisturizer products hydrate the skin to the expected levels, and this extent of skin hydration varies with duration of application of these products.

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Authors+Show Affiliations

Tippavajhala VK
Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India. krissrcm@gmail.com.
Magrini TD
Laboratory of Biomedical Vibrational Spectroscopy (LEVB), Institute of Research and Development (IP&D), Universidade do Vale do Paraiba (UNIVAP), Av. Shishima Hifumi, 2911, Urbanova, CEP: 12.244-000, São José dos Campos, SP, Brazil.
Matsuo DC
Laboratory of Biomedical Vibrational Spectroscopy (LEVB), Institute of Research and Development (IP&D), Universidade do Vale do Paraiba (UNIVAP), Av. Shishima Hifumi, 2911, Urbanova, CEP: 12.244-000, São José dos Campos, SP, Brazil.
Silva MGP
Laboratory of Biomedical Vibrational Spectroscopy (LEVB), Institute of Research and Development (IP&D), Universidade do Vale do Paraiba (UNIVAP), Av. Shishima Hifumi, 2911, Urbanova, CEP: 12.244-000, São José dos Campos, SP, Brazil.
Favero PP
Biomedical Engineering Innovation Center, Biomedical Vibrational Spectroscopy Group, Universidade Brasil-UNBr, Rua Carolina Fonseca, 235-08230-030, Itaquera, Sao Paulo, Brazil. DermoProbes: Skin and Hair Technology Optimization, Av. Cassiano Ricardo, 601-Parque Res. Aquarius-Salas 73/74, São José dos Campos, SP, 12246-870, Brazil.
De Paula LR
Natura Inovação e Tecnologia de Produtos Ltda.-Cajamar, Via de Acesso Km 30.5,predio 1o A, Cajamar, SP, 07790-190, Brazil.
Martin AA
Biomedical Engineering Innovation Center, Biomedical Vibrational Spectroscopy Group, Universidade Brasil-UNBr, Rua Carolina Fonseca, 235-08230-030, Itaquera, Sao Paulo, Brazil. airton.a.martin@gmail.com. DermoProbes: Skin and Hair Technology Optimization, Av. Cassiano Ricardo, 601-Parque Res. Aquarius-Salas 73/74, São José dos Campos, SP, 12246-870, Brazil. airton.a.martin@gmail.com. Department of Physics, Federal University of Piaui-UFPI, Teresina, Piuai, Brazil. airton.a.martin@gmail.com.

MeSH

AdultFemaleHumansSkinSkin CreamSpectrum Analysis, RamanWater

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30136174

Citation

Tippavajhala, Vamshi Krishna, et al. "In Vivo Determination of Moisturizers Efficacy On Human Skin Hydration By Confocal Raman Spectroscopy." AAPS PharmSciTech, vol. 19, no. 7, 2018, pp. 3177-3186.
Tippavajhala VK, Magrini TD, Matsuo DC, et al. In Vivo Determination of Moisturizers Efficacy on Human Skin Hydration by Confocal Raman Spectroscopy. AAPS PharmSciTech. 2018;19(7):3177-3186.
Tippavajhala, V. K., Magrini, T. D., Matsuo, D. C., Silva, M. G. P., Favero, P. P., De Paula, L. R., & Martin, A. A. (2018). In Vivo Determination of Moisturizers Efficacy on Human Skin Hydration by Confocal Raman Spectroscopy. AAPS PharmSciTech, 19(7), 3177-3186. https://doi.org/10.1208/s12249-018-1143-8
Tippavajhala VK, et al. In Vivo Determination of Moisturizers Efficacy On Human Skin Hydration By Confocal Raman Spectroscopy. AAPS PharmSciTech. 2018;19(7):3177-3186. PubMed PMID: 30136174.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In Vivo Determination of Moisturizers Efficacy on Human Skin Hydration by Confocal Raman Spectroscopy. AU - Tippavajhala,Vamshi Krishna, AU - Magrini,Taciana D, AU - Matsuo,Daniele C, AU - Silva,Michely G P, AU - Favero,Priscila P, AU - De Paula,Leonardo Rodrigues, AU - Martin,Airton Abrahão, Y1 - 2018/08/22/ PY - 2018/06/07/received PY - 2018/08/06/accepted PY - 2018/8/24/pubmed PY - 2018/11/28/medline PY - 2018/8/24/entrez KW - confocal Raman spectroscopy KW - in vivo human skin hydration KW - moisturizer efficacy SP - 3177 EP - 3186 JF - AAPS PharmSciTech JO - AAPS PharmSciTech VL - 19 IS - 7 N2 - This research work deals with in vivo testing of the efficacy of commercial moisturizer products on the hydration of human skin, as there are various in vitro and ex vivo studies questioning their activity. Confocal Raman spectroscopy was used for this purpose of assessing the efficacy of moisturizers on skin hydration mainly owing to its simple, non-invasive, non-destructive, timesaving, and cost-effective nature. Water content and natural moisturizing factor (NMF) of stratum corneum were analyzed and compared using this method at high wavenumber (2500-4000 cm-1) and fingerprint (400-1800 cm-1) spectral regions, respectively, as these two parameters are correlated to skin hydration. Four commercial moisturizer products of different brands were tested on volar forearm region of healthy human female volunteers. This study was conducted for a period of 30 days with 0, 7, and 30 days as time points of analysis. The results of this study clearly indicate that not all the moisturizer products hydrate the skin to the expected levels, and this extent of skin hydration varies with duration of application of these products. SN - 1530-9932 UR - https://www.unboundmedicine.com/medline/citation/30136174/In_Vivo_Determination_of_Moisturizers_Efficacy_on_Human_Skin_Hydration_by_Confocal_Raman_Spectroscopy_ DB - PRIME DP - Unbound Medicine ER -