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Abnormal hippocampal neurogenesis in Parkinson's disease: relevance to a new therapeutic target for depression with Parkinson's disease.
Arch Pharm Res. 2018 Oct; 41(10):943-954.AP

Abstract

Parkinson's disease (PD) is a common progressive neurodegenerative disorder characterized by motor dysfunction, including bradykinesia, tremor, rigidity, and postural instability. Recent clinical findings recognize PD as a complex disease with diverse neuropsychiatric complications. Depression is the most frequent non-motor psychiatric symptom experienced in PD, and it is associated with poor quality of life. While the pathophysiology of PD-associated depression is not directly related to neurodegenerative processes in the substantia nigra, underlying mechanisms remain unclear and there are few symptomatic treatments. Altered adult hippocampal neurogenesis is considered crucial for the development and treatment of depression. In genetic animal models and human postmortem studies of PD, severely impaired adult neurogenesis has been observed, with patients showing hippocampal atrophy and disrupted hippocampal neurogenesis. Because adult newborn neurons appear to exert various functions, which relate to non-motor symptoms observed in PD, there might be a close correlation between malformation of newborn neurons in the adult hippocampus and depressive symptoms. Here, we discuss current concepts regarding impaired hippocampal neurogenesis and non-motor symptoms of PD, and review PD-associated pathophysiological factors regulating neurogenesis, including inflammatory signaling and autophagy. We present a novel framework for targeting adult hippocampal neurogenesis, which could provide a promising treatment for PD-associated depression.

Authors+Show Affiliations

College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, Seongnam-si, Gyeonggi-do, 13488, Republic of Korea.College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, Seongnam-si, Gyeonggi-do, 13488, Republic of Korea.College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, Seongnam-si, Gyeonggi-do, 13488, Republic of Korea. hjchoi3@cha.ac.kr.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30136247

Citation

Lim, Juhee, et al. "Abnormal Hippocampal Neurogenesis in Parkinson's Disease: Relevance to a New Therapeutic Target for Depression With Parkinson's Disease." Archives of Pharmacal Research, vol. 41, no. 10, 2018, pp. 943-954.
Lim J, Bang Y, Choi HJ. Abnormal hippocampal neurogenesis in Parkinson's disease: relevance to a new therapeutic target for depression with Parkinson's disease. Arch Pharm Res. 2018;41(10):943-954.
Lim, J., Bang, Y., & Choi, H. J. (2018). Abnormal hippocampal neurogenesis in Parkinson's disease: relevance to a new therapeutic target for depression with Parkinson's disease. Archives of Pharmacal Research, 41(10), 943-954. https://doi.org/10.1007/s12272-018-1063-x
Lim J, Bang Y, Choi HJ. Abnormal Hippocampal Neurogenesis in Parkinson's Disease: Relevance to a New Therapeutic Target for Depression With Parkinson's Disease. Arch Pharm Res. 2018;41(10):943-954. PubMed PMID: 30136247.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abnormal hippocampal neurogenesis in Parkinson's disease: relevance to a new therapeutic target for depression with Parkinson's disease. AU - Lim,Juhee, AU - Bang,Yeojin, AU - Choi,Hyun Jin, Y1 - 2018/08/22/ PY - 2018/02/28/received PY - 2018/07/31/accepted PY - 2018/8/24/pubmed PY - 2018/11/22/medline PY - 2018/8/24/entrez KW - Autophagy KW - Depression KW - Hippocampus KW - Inflammation KW - Neurogenesis KW - Parkinson’s disease SP - 943 EP - 954 JF - Archives of pharmacal research JO - Arch Pharm Res VL - 41 IS - 10 N2 - Parkinson's disease (PD) is a common progressive neurodegenerative disorder characterized by motor dysfunction, including bradykinesia, tremor, rigidity, and postural instability. Recent clinical findings recognize PD as a complex disease with diverse neuropsychiatric complications. Depression is the most frequent non-motor psychiatric symptom experienced in PD, and it is associated with poor quality of life. While the pathophysiology of PD-associated depression is not directly related to neurodegenerative processes in the substantia nigra, underlying mechanisms remain unclear and there are few symptomatic treatments. Altered adult hippocampal neurogenesis is considered crucial for the development and treatment of depression. In genetic animal models and human postmortem studies of PD, severely impaired adult neurogenesis has been observed, with patients showing hippocampal atrophy and disrupted hippocampal neurogenesis. Because adult newborn neurons appear to exert various functions, which relate to non-motor symptoms observed in PD, there might be a close correlation between malformation of newborn neurons in the adult hippocampus and depressive symptoms. Here, we discuss current concepts regarding impaired hippocampal neurogenesis and non-motor symptoms of PD, and review PD-associated pathophysiological factors regulating neurogenesis, including inflammatory signaling and autophagy. We present a novel framework for targeting adult hippocampal neurogenesis, which could provide a promising treatment for PD-associated depression. SN - 0253-6269 UR - https://www.unboundmedicine.com/medline/citation/30136247/Abnormal_hippocampal_neurogenesis_in_Parkinson's_disease:_relevance_to_a_new_therapeutic_target_for_depression_with_Parkinson's_disease_ L2 - https://dx.doi.org/10.1007/s12272-018-1063-x DB - PRIME DP - Unbound Medicine ER -
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