Tags

Type your tag names separated by a space and hit enter

Cognitive ability is associated with changes in the functional organization of the cognitive control brain network.
Hum Brain Mapp. 2018 12; 39(12):5028-5038.HB

Abstract

Cognitive control is one of the most important skills in day-to-day social and intellectual functioning but we are yet to understand the neural basis of the group of behaviors required to carry this out. Here, we probed changes over time in the brain network associated with cognitive control (the dorsolateral prefrontal cortex, the dorsal posterior parietal cortex, and the dorsal anterior cingulate cortex) using both behavioral assays and functional brain imaging during a selective working memory task in 69 healthy participants within the age range 18-38 years (mean: 25, SD: ±6), assessed twice, 2 years apart. We aimed to explore the relationship of changing network activation and connectivity with behavioral tasks associated with cognitive control in this otherwise neurodevelopmentally stable group. We found that increased connectivity between frontoparietal cognitive control network regions during the working memory task was associated with improved memory and executive functions over the 2-year period and that this association was not impacted by age, gender, or baseline performance. These results provide evidence that changes in the functional organization of the cognitive control brain network occur despite the absence of neurodevelopment, aging or targeted cognitive training effects, and could modulate cognitive performance in early to mid-adulthood. Understanding how and why this change is occurring could provide insights into the mechanisms through which cognitive control ability is cultivated over time. This could aid in the development of interventions in cases where cognitive control is impaired.

Authors+Show Affiliations

Brain Dynamics Centre, The Westmead Institute for Medical Research, The University of Sydney, Westmead, New South Wales, Australia.Brain Dynamics Centre, The Westmead Institute for Medical Research, The University of Sydney, Westmead, New South Wales, Australia. Psychiatry and Behavioral Sciences, Stanford University, Stanford, California. VA Palo Alto (Sierra-Pacific MIRECC), Palo Alto, California.Brain Dynamics Centre, The Westmead Institute for Medical Research, The University of Sydney, Westmead, New South Wales, Australia.Brain Dynamics Centre, The Westmead Institute for Medical Research, The University of Sydney, Westmead, New South Wales, Australia. Sydney Translational Imaging Laboratory, Heart Research Institute, Charles Perkins Centre and Sydney Medical School, University of Sydney, New South Wales, Australia. Department of Radiology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.Department of Radiology, Westmead Hospital, Westmead, New South Wales, Australia. Faculty of Health Science, The Discipline of Medical Radiation Sciences, The University of Sydney, New South Wales, Australia.Department of Radiology, Westmead Hospital, Westmead, New South Wales, Australia.Brain Dynamics Centre, The Westmead Institute for Medical Research, The University of Sydney, Westmead, New South Wales, Australia. Discipline of Psychiatry, Sydney Medical School, Westmead, Sydney, Australia.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30136345

Citation

A Breukelaar, Isabella, et al. "Cognitive Ability Is Associated With Changes in the Functional Organization of the Cognitive Control Brain Network." Human Brain Mapping, vol. 39, no. 12, 2018, pp. 5028-5038.
A Breukelaar I, Williams LM, Antees C, et al. Cognitive ability is associated with changes in the functional organization of the cognitive control brain network. Hum Brain Mapp. 2018;39(12):5028-5038.
A Breukelaar, I., Williams, L. M., Antees, C., Grieve, S. M., Foster, S. L., Gomes, L., & Korgaonkar, M. S. (2018). Cognitive ability is associated with changes in the functional organization of the cognitive control brain network. Human Brain Mapping, 39(12), 5028-5038. https://doi.org/10.1002/hbm.24342
A Breukelaar I, et al. Cognitive Ability Is Associated With Changes in the Functional Organization of the Cognitive Control Brain Network. Hum Brain Mapp. 2018;39(12):5028-5038. PubMed PMID: 30136345.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cognitive ability is associated with changes in the functional organization of the cognitive control brain network. AU - A Breukelaar,Isabella, AU - Williams,Leanne M, AU - Antees,Cassandra, AU - Grieve,Stuart M, AU - Foster,Sheryl L, AU - Gomes,Lavier, AU - Korgaonkar,Mayuresh S, Y1 - 2018/08/23/ PY - 2018/05/30/received PY - 2018/07/23/revised PY - 2018/07/23/accepted PY - 2018/8/24/pubmed PY - 2019/7/4/medline PY - 2018/8/24/entrez KW - brain networks KW - cognitive control KW - connectivity KW - fMRI KW - neurodevelopment KW - working memory SP - 5028 EP - 5038 JF - Human brain mapping JO - Hum Brain Mapp VL - 39 IS - 12 N2 - Cognitive control is one of the most important skills in day-to-day social and intellectual functioning but we are yet to understand the neural basis of the group of behaviors required to carry this out. Here, we probed changes over time in the brain network associated with cognitive control (the dorsolateral prefrontal cortex, the dorsal posterior parietal cortex, and the dorsal anterior cingulate cortex) using both behavioral assays and functional brain imaging during a selective working memory task in 69 healthy participants within the age range 18-38 years (mean: 25, SD: ±6), assessed twice, 2 years apart. We aimed to explore the relationship of changing network activation and connectivity with behavioral tasks associated with cognitive control in this otherwise neurodevelopmentally stable group. We found that increased connectivity between frontoparietal cognitive control network regions during the working memory task was associated with improved memory and executive functions over the 2-year period and that this association was not impacted by age, gender, or baseline performance. These results provide evidence that changes in the functional organization of the cognitive control brain network occur despite the absence of neurodevelopment, aging or targeted cognitive training effects, and could modulate cognitive performance in early to mid-adulthood. Understanding how and why this change is occurring could provide insights into the mechanisms through which cognitive control ability is cultivated over time. This could aid in the development of interventions in cases where cognitive control is impaired. SN - 1097-0193 UR - https://www.unboundmedicine.com/medline/citation/30136345/Cognitive_ability_is_associated_with_changes_in_the_functional_organization_of_the_cognitive_control_brain_network_ L2 - https://doi.org/10.1002/hbm.24342 DB - PRIME DP - Unbound Medicine ER -