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Incorporation of nanofibrillated chitosan into electrospun PCL nanofibers makes scaffolds with enhanced mechanical and biological properties.
Carbohydr Polym 2018; 199:628-640CP

Abstract

Fabricating polycaprolactone (PCL) composite can be a facile approach to improve wettability, mechanical properties and cellular compatibility of PCL-based scaffolds. In this study, nanofibrillated chitosan (NC) was utilized as dispersing phase in PCL matrix to acquire electrospun nanocomposite fibrous scaffolds. Various amounts of NC were added to PCL solutions and the solutions were electrospun under constant electrospinning parameters. Adding NC to PCL solutions was accompanied with notable changes in the solutions viscosity, conductivity and electrospinnability. Whiles the pure PCL solutions with concentration of 8 wt. % and 10 wt. % were not electrospinnable, adding 5-10 % NC made them electrospinnable. The mechanical properties, wettability and cellular compatibility of electrospun PCL/NC composites were improved as well. PCL/NC scaffolds showed remarkable enhancement in both tensile strength and Young's modulus compared to neat PCL scaffold. Contact angle measurements revealed improvement in wettability of scaffolds after adding NC. In addition, proliferation and adhesion of cells was enhanced when NC was incorporated to nanofibers. The results suggest PCL/NC as a proper scaffold for tissue engineering applications.

Authors+Show Affiliations

Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: e_mirzaei@sums.ac.ir.Transplant Research Center, Shiraz University of Medical Sciences Shiraz, Iran.Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30143171

Citation

Fadaie, Milad, et al. "Incorporation of Nanofibrillated Chitosan Into Electrospun PCL Nanofibers Makes Scaffolds With Enhanced Mechanical and Biological Properties." Carbohydrate Polymers, vol. 199, 2018, pp. 628-640.
Fadaie M, Mirzaei E, Geramizadeh B, et al. Incorporation of nanofibrillated chitosan into electrospun PCL nanofibers makes scaffolds with enhanced mechanical and biological properties. Carbohydr Polym. 2018;199:628-640.
Fadaie, M., Mirzaei, E., Geramizadeh, B., & Asvar, Z. (2018). Incorporation of nanofibrillated chitosan into electrospun PCL nanofibers makes scaffolds with enhanced mechanical and biological properties. Carbohydrate Polymers, 199, pp. 628-640. doi:10.1016/j.carbpol.2018.07.061.
Fadaie M, et al. Incorporation of Nanofibrillated Chitosan Into Electrospun PCL Nanofibers Makes Scaffolds With Enhanced Mechanical and Biological Properties. Carbohydr Polym. 2018 Nov 1;199:628-640. PubMed PMID: 30143171.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Incorporation of nanofibrillated chitosan into electrospun PCL nanofibers makes scaffolds with enhanced mechanical and biological properties. AU - Fadaie,Milad, AU - Mirzaei,Esmaeil, AU - Geramizadeh,Bita, AU - Asvar,Zahra, Y1 - 2018/07/19/ PY - 2018/05/08/received PY - 2018/06/26/revised PY - 2018/07/19/accepted PY - 2018/8/26/entrez PY - 2018/8/26/pubmed PY - 2018/12/21/medline KW - Nanofiber KW - Nanofibrillated chitosan KW - Polycaprolactone KW - Scaffold SP - 628 EP - 640 JF - Carbohydrate polymers JO - Carbohydr Polym VL - 199 N2 - Fabricating polycaprolactone (PCL) composite can be a facile approach to improve wettability, mechanical properties and cellular compatibility of PCL-based scaffolds. In this study, nanofibrillated chitosan (NC) was utilized as dispersing phase in PCL matrix to acquire electrospun nanocomposite fibrous scaffolds. Various amounts of NC were added to PCL solutions and the solutions were electrospun under constant electrospinning parameters. Adding NC to PCL solutions was accompanied with notable changes in the solutions viscosity, conductivity and electrospinnability. Whiles the pure PCL solutions with concentration of 8 wt. % and 10 wt. % were not electrospinnable, adding 5-10 % NC made them electrospinnable. The mechanical properties, wettability and cellular compatibility of electrospun PCL/NC composites were improved as well. PCL/NC scaffolds showed remarkable enhancement in both tensile strength and Young's modulus compared to neat PCL scaffold. Contact angle measurements revealed improvement in wettability of scaffolds after adding NC. In addition, proliferation and adhesion of cells was enhanced when NC was incorporated to nanofibers. The results suggest PCL/NC as a proper scaffold for tissue engineering applications. SN - 1879-1344 UR - https://www.unboundmedicine.com/medline/citation/30143171/Incorporation_of_nanofibrillated_chitosan_into_electrospun_PCL_nanofibers_makes_scaffolds_with_enhanced_mechanical_and_biological_properties_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0144-8617(18)30852-X DB - PRIME DP - Unbound Medicine ER -