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Role of Sperm Morphology in Deciding Between Various Assisted Reproduction Technologies.
Eur Urol Focus 2018; 4(3):311-313EU

Abstract

Sperm morphology has long been used as a clinical tool in the assessment of men with infertility. In the past, high percentages of abnormal sperm have been associated with lower pregnancy rates. However, significant intra- and interlaboratory variation has been found for sperm morphology assessment and several recent meta-analyses have demonstrated that sperm morphology is no longer predictive of lower pregnancy rates when using assisted reproduction technology (ART). As the validity of the test and the predictive nature of sperm morphology are no longer as robust as before, clinicians should not rely on percentage thresholds for normal sperm when deciding on which ART to opt for. Instead, clinicians should base ART decisions on other reproductive factors.

Authors+Show Affiliations

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.Department of Gynecology/Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.Departments of Urology and Genetic Medicine, Weill Cornell Medical Center, New York, NY, USA. Electronic address: dlamb@med.cornell.edu.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

30143470

Citation

Kohn, Taylor P., et al. "Role of Sperm Morphology in Deciding Between Various Assisted Reproduction Technologies." European Urology Focus, vol. 4, no. 3, 2018, pp. 311-313.
Kohn TP, Kohn JR, Lamb DJ. Role of Sperm Morphology in Deciding Between Various Assisted Reproduction Technologies. Eur Urol Focus. 2018;4(3):311-313.
Kohn, T. P., Kohn, J. R., & Lamb, D. J. (2018). Role of Sperm Morphology in Deciding Between Various Assisted Reproduction Technologies. European Urology Focus, 4(3), pp. 311-313. doi:10.1016/j.euf.2018.07.029.
Kohn TP, Kohn JR, Lamb DJ. Role of Sperm Morphology in Deciding Between Various Assisted Reproduction Technologies. Eur Urol Focus. 2018;4(3):311-313. PubMed PMID: 30143470.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of Sperm Morphology in Deciding Between Various Assisted Reproduction Technologies. AU - Kohn,Taylor P, AU - Kohn,Jaden R, AU - Lamb,Dolores J, Y1 - 2018/08/22/ PY - 2018/06/10/received PY - 2018/07/07/revised PY - 2018/07/18/accepted PY - 2018/8/26/pubmed PY - 2019/4/2/medline PY - 2018/8/26/entrez KW - Infertility KW - Insemination, Artificial, Homologous KW - Male KW - Semen analysis KW - Sperm morphology KW - Teratozoospermia SP - 311 EP - 313 JF - European urology focus JO - Eur Urol Focus VL - 4 IS - 3 N2 - Sperm morphology has long been used as a clinical tool in the assessment of men with infertility. In the past, high percentages of abnormal sperm have been associated with lower pregnancy rates. However, significant intra- and interlaboratory variation has been found for sperm morphology assessment and several recent meta-analyses have demonstrated that sperm morphology is no longer predictive of lower pregnancy rates when using assisted reproduction technology (ART). As the validity of the test and the predictive nature of sperm morphology are no longer as robust as before, clinicians should not rely on percentage thresholds for normal sperm when deciding on which ART to opt for. Instead, clinicians should base ART decisions on other reproductive factors. SN - 2405-4569 UR - https://www.unboundmedicine.com/medline/citation/30143470/Role_of_Sperm_Morphology_in_Deciding_Between_Various_Assisted_Reproduction_Technologies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2405-4569(18)30213-X DB - PRIME DP - Unbound Medicine ER -