Tags

Type your tag names separated by a space and hit enter

Optimizing Placebo and Minimizing Nocebo to Reduce Pain, Catastrophizing, and Opioid Use: A Review of the Science and an Evidence-Informed Clinical Toolkit.
Int Rev Neurobiol. 2018; 139:129-157.IR

Abstract

Pain, a noxious psychosensory experience, motivates escape behavior to assure protection and survival. Psychological factors alter the experience and trajectory of pain, as well as behavior and treatment response. In the context of pain, the placebo effect (expectation for pain relief) releases endogenous opioids and facilitates analgesia from exogenously administered opioids. Nocebo hyperalgesia (expectation for persistent or worsening pain) opposes endogenous opioid analgesia and patient engagement in prescription opioid tapering. Reductions in nocebo hyperalgesia and pain catastrophizing may enhance descending modulation of pain, mediate adaptive structural brain changes and promote patient engagement in opioid tapering. Interventions that minimize nocebo and optimize placebo may adaptively shape the central nervous system toward pain relief and potentially opioid reduction. Here we provide a critical description of catastrophizing and its impact on pain, placebo and nocebo effects. We also consider the importance of minimizing nocebo and optimizing placebo effects during prescription opioid tapering, and offer a clinical toolkit of resources to accomplish these goals clinically.

Authors+Show Affiliations

School of Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Division of Pain Medicine, Psychiatry and Behavioral Sciences (by courtesy), Stanford University, Palo Alto, CA, United States. Electronic address: bdarnall@stanford.edu.Department of Pain Translational Symptom Science, School of Nursing, University of Maryland, Baltimore, MD, United States; Departments of Anesthesiology and Psychiatry, School of Medicine, University of Maryland, Baltimore, MD, United States; Center to Advance Chronic Pain Research, University of Maryland, Baltimore, MD, United States.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

30146045

Citation

Darnall, Beth D., and Luana Colloca. "Optimizing Placebo and Minimizing Nocebo to Reduce Pain, Catastrophizing, and Opioid Use: a Review of the Science and an Evidence-Informed Clinical Toolkit." International Review of Neurobiology, vol. 139, 2018, pp. 129-157.
Darnall BD, Colloca L. Optimizing Placebo and Minimizing Nocebo to Reduce Pain, Catastrophizing, and Opioid Use: A Review of the Science and an Evidence-Informed Clinical Toolkit. Int Rev Neurobiol. 2018;139:129-157.
Darnall, B. D., & Colloca, L. (2018). Optimizing Placebo and Minimizing Nocebo to Reduce Pain, Catastrophizing, and Opioid Use: A Review of the Science and an Evidence-Informed Clinical Toolkit. International Review of Neurobiology, 139, 129-157. https://doi.org/10.1016/bs.irn.2018.07.022
Darnall BD, Colloca L. Optimizing Placebo and Minimizing Nocebo to Reduce Pain, Catastrophizing, and Opioid Use: a Review of the Science and an Evidence-Informed Clinical Toolkit. Int Rev Neurobiol. 2018;139:129-157. PubMed PMID: 30146045.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Optimizing Placebo and Minimizing Nocebo to Reduce Pain, Catastrophizing, and Opioid Use: A Review of the Science and an Evidence-Informed Clinical Toolkit. AU - Darnall,Beth D, AU - Colloca,Luana, Y1 - 2018/08/06/ PY - 2018/8/28/entrez PY - 2018/8/28/pubmed PY - 2019/2/14/medline KW - Catastrophizing KW - Chronic pain KW - Evidence-based KW - Expectations KW - Nocebo KW - Opioids KW - Pain KW - Patient-centered KW - Placebo KW - Treatment SP - 129 EP - 157 JF - International review of neurobiology JO - Int. Rev. Neurobiol. VL - 139 N2 - Pain, a noxious psychosensory experience, motivates escape behavior to assure protection and survival. Psychological factors alter the experience and trajectory of pain, as well as behavior and treatment response. In the context of pain, the placebo effect (expectation for pain relief) releases endogenous opioids and facilitates analgesia from exogenously administered opioids. Nocebo hyperalgesia (expectation for persistent or worsening pain) opposes endogenous opioid analgesia and patient engagement in prescription opioid tapering. Reductions in nocebo hyperalgesia and pain catastrophizing may enhance descending modulation of pain, mediate adaptive structural brain changes and promote patient engagement in opioid tapering. Interventions that minimize nocebo and optimize placebo may adaptively shape the central nervous system toward pain relief and potentially opioid reduction. Here we provide a critical description of catastrophizing and its impact on pain, placebo and nocebo effects. We also consider the importance of minimizing nocebo and optimizing placebo effects during prescription opioid tapering, and offer a clinical toolkit of resources to accomplish these goals clinically. SN - 2162-5514 UR - https://www.unboundmedicine.com/medline/citation/30146045/Optimizing_Placebo_and_Minimizing_Nocebo_to_Reduce_Pain_Catastrophizing_and_Opioid_Use:_A_Review_of_the_Science_and_an_Evidence_Informed_Clinical_Toolkit_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0074-7742(18)30051-5 DB - PRIME DP - Unbound Medicine ER -