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The Relationship Between Statin Action On Thyroid Autoimmunity And Vitamin D Status: A Pilot Study.
Exp Clin Endocrinol Diabetes 2019; 127(1):23-28EC

Abstract

BACKGROUND

Both vitamin D preparations and high-dose statin therapy were found to reduce thyroid antibody titers.

OBJECTIVE

The purpose of this study was to assess whether vitamin D status determines the effect of statin therapy on thyroid autoimmunity.

METHODS

The study population consisted of 39 euthyroid women with Hashimoto's thyroiditis and moderate or moderately high cardiovascular risk divided into two groups: women with vitamin D deficiency or insufficiency (group A; n=19) and women with normal vitamin D status (group B, n=20). All patients received atorvastatin therapy (20-40 mg daily) for the following 6 months. Plasma lipids, circulating levels of thyrotropin, free thyroid hormones, prolactin and 25-hydroxyvitamin D, titers of thyroid peroxidase and thyroglobulin antibodies, as well as Jostel's, the SPINA-GT and the SPINA-GD indices were assessed at the beginning and at the end of the study.

RESULTS

The study completed all women. At baseline, with the exception of 25-hydroxyvitamin D, there were no significant differences between both study groups in plasma lipids, circulating hormone levels and titers of thyroid peroxidase and thyroglobulin antibodies. Despite improving plasma lipids in both study groups, atorvastatin reduced thyroid antibody titers only in women with normal vitamin D status. Moreover, in this group of patients, atorvastatin increased the SPINA-GT index. Circulating levels of the measured hormones, Jostel's thyrotropin index and the SPINA-GD index remained at a similar level throughout the study.

CONCLUSIONS

The results of the study suggest that the effect of atorvastatin therapy on thyroid autoimmunity depends on vitamin D status.

Authors+Show Affiliations

Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30149415

Citation

Krysiak, Robert, et al. "The Relationship Between Statin Action On Thyroid Autoimmunity and Vitamin D Status: a Pilot Study." Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association, vol. 127, no. 1, 2019, pp. 23-28.
Krysiak R, Szkróbka W, Okopień B. The Relationship Between Statin Action On Thyroid Autoimmunity And Vitamin D Status: A Pilot Study. Exp Clin Endocrinol Diabetes. 2019;127(1):23-28.
Krysiak, R., Szkróbka, W., & Okopień, B. (2019). The Relationship Between Statin Action On Thyroid Autoimmunity And Vitamin D Status: A Pilot Study. Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association, 127(1), pp. 23-28. doi:10.1055/a-0669-9309.
Krysiak R, Szkróbka W, Okopień B. The Relationship Between Statin Action On Thyroid Autoimmunity and Vitamin D Status: a Pilot Study. Exp Clin Endocrinol Diabetes. 2019;127(1):23-28. PubMed PMID: 30149415.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Relationship Between Statin Action On Thyroid Autoimmunity And Vitamin D Status: A Pilot Study. AU - Krysiak,Robert, AU - Szkróbka,Witold, AU - Okopień,Bogusław, Y1 - 2018/08/27/ PY - 2018/8/28/pubmed PY - 2019/4/5/medline PY - 2018/8/28/entrez SP - 23 EP - 28 JF - Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association JO - Exp. Clin. Endocrinol. Diabetes VL - 127 IS - 1 N2 - BACKGROUND: Both vitamin D preparations and high-dose statin therapy were found to reduce thyroid antibody titers. OBJECTIVE: The purpose of this study was to assess whether vitamin D status determines the effect of statin therapy on thyroid autoimmunity. METHODS: The study population consisted of 39 euthyroid women with Hashimoto's thyroiditis and moderate or moderately high cardiovascular risk divided into two groups: women with vitamin D deficiency or insufficiency (group A; n=19) and women with normal vitamin D status (group B, n=20). All patients received atorvastatin therapy (20-40 mg daily) for the following 6 months. Plasma lipids, circulating levels of thyrotropin, free thyroid hormones, prolactin and 25-hydroxyvitamin D, titers of thyroid peroxidase and thyroglobulin antibodies, as well as Jostel's, the SPINA-GT and the SPINA-GD indices were assessed at the beginning and at the end of the study. RESULTS: The study completed all women. At baseline, with the exception of 25-hydroxyvitamin D, there were no significant differences between both study groups in plasma lipids, circulating hormone levels and titers of thyroid peroxidase and thyroglobulin antibodies. Despite improving plasma lipids in both study groups, atorvastatin reduced thyroid antibody titers only in women with normal vitamin D status. Moreover, in this group of patients, atorvastatin increased the SPINA-GT index. Circulating levels of the measured hormones, Jostel's thyrotropin index and the SPINA-GD index remained at a similar level throughout the study. CONCLUSIONS: The results of the study suggest that the effect of atorvastatin therapy on thyroid autoimmunity depends on vitamin D status. SN - 1439-3646 UR - https://www.unboundmedicine.com/medline/citation/30149415/The_Relationship_Between_Statin_Action_On_Thyroid_Autoimmunity_And_Vitamin_D_Status:_A_Pilot_Study_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/a-0669-9309 DB - PRIME DP - Unbound Medicine ER -