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Tianeptine Abuse and Dependence: Case Report and Literature Review.
Psychosomatics 2018; 59(6):547-553P

Abstract

BACKGROUND

Tianeptine (Stablon, Coaxil) abuse and dependence has become increasingly prominent worldwide with recent presence in the United States.

OBJECTIVE

In this article, we add a case to the growing literature on tianeptine dependence, the first of which is concerning for the presence of an adulterant, and present a comprehensive literature review.

METHODS

A literature search was conducted on July 2, 2018 on PubMed for articles using the keywords "tianeptine abuse" and "tianeptine dependence."

RESULTS

Literature search resulted in 25 articles and encompassed 65 patients. A majority of patients were male and age ranged from 19 to 67. Routes of intake included oral, intravenous, and insufflation. In the 15 cases of overdose, 8 combined ingestion with at least one other substance, of which 3 resulted in death. Six additional deaths are reported involving tianeptine (9 total).

CONCLUSION

Tianeptine abuse and dependence has become a cause for concern in approved markets with recent emergence in the United States. Psychiatrists should be aware of a potentially fatal opiate-like withdrawal in the absence of positive urine drug screens or cases where withdrawal does not follow expected patterns. Tianeptine users should be educated regarding risk associated with this drug. Without further intervention, additional cases should be anticipated.

Authors+Show Affiliations

University of California, San Diego (UCSD) Department of Psychiatry, La Jolla, CA; VA San Diego Healthcare System, San Diego, CA.University of California, San Diego (UCSD) Department of Psychiatry, La Jolla, CA; VA San Diego Healthcare System, San Diego, CA.University of California, San Diego (UCSD) Department of Psychiatry, La Jolla, CA; VA San Diego Healthcare System, San Diego, CA.University of California, San Diego (UCSD) Department of Psychiatry, La Jolla, CA; VA San Diego Healthcare System, San Diego, CA.

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

30149933

Citation

Lauhan, Rahul, et al. "Tianeptine Abuse and Dependence: Case Report and Literature Review." Psychosomatics, vol. 59, no. 6, 2018, pp. 547-553.
Lauhan R, Hsu A, Alam A, et al. Tianeptine Abuse and Dependence: Case Report and Literature Review. Psychosomatics. 2018;59(6):547-553.
Lauhan, R., Hsu, A., Alam, A., & Beizai, K. (2018). Tianeptine Abuse and Dependence: Case Report and Literature Review. Psychosomatics, 59(6), pp. 547-553. doi:10.1016/j.psym.2018.07.006.
Lauhan R, et al. Tianeptine Abuse and Dependence: Case Report and Literature Review. Psychosomatics. 2018;59(6):547-553. PubMed PMID: 30149933.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tianeptine Abuse and Dependence: Case Report and Literature Review. AU - Lauhan,Rahul, AU - Hsu,Alan, AU - Alam,Al, AU - Beizai,Kristin, Y1 - 2018/07/19/ PY - 2018/06/13/received PY - 2018/07/08/revised PY - 2018/07/13/accepted PY - 2018/8/29/pubmed PY - 2019/6/25/medline PY - 2018/8/29/entrez KW - abuse KW - addiction KW - dependence KW - management KW - tianeptine SP - 547 EP - 553 JF - Psychosomatics JO - Psychosomatics VL - 59 IS - 6 N2 - BACKGROUND: Tianeptine (Stablon, Coaxil) abuse and dependence has become increasingly prominent worldwide with recent presence in the United States. OBJECTIVE: In this article, we add a case to the growing literature on tianeptine dependence, the first of which is concerning for the presence of an adulterant, and present a comprehensive literature review. METHODS: A literature search was conducted on July 2, 2018 on PubMed for articles using the keywords "tianeptine abuse" and "tianeptine dependence." RESULTS: Literature search resulted in 25 articles and encompassed 65 patients. A majority of patients were male and age ranged from 19 to 67. Routes of intake included oral, intravenous, and insufflation. In the 15 cases of overdose, 8 combined ingestion with at least one other substance, of which 3 resulted in death. Six additional deaths are reported involving tianeptine (9 total). CONCLUSION: Tianeptine abuse and dependence has become a cause for concern in approved markets with recent emergence in the United States. Psychiatrists should be aware of a potentially fatal opiate-like withdrawal in the absence of positive urine drug screens or cases where withdrawal does not follow expected patterns. Tianeptine users should be educated regarding risk associated with this drug. Without further intervention, additional cases should be anticipated. SN - 1545-7206 UR - https://www.unboundmedicine.com/medline/citation/30149933/Tianeptine_Abuse_and_Dependence:_Case_Report_and_Literature_Review L2 - https://linkinghub.elsevier.com/retrieve/pii/S0033-3182(18)30327-X DB - PRIME DP - Unbound Medicine ER -