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The Drug Developments of Hydrogen Sulfide on Cardiovascular Disease.
Oxid Med Cell Longev. 2018; 2018:4010395.OM

Abstract

The recognition of hydrogen sulfide (H2S) has been evolved from a toxic gas to a physiological mediator, exhibiting properties similar to NO and CO. On the one hand, H2S is produced from L-cysteine by enzymes of cystathionine γ-lyase (CSE) and cystathionine β-synthase (CBS), 3-mercaptopyruvate sulfurtransferase (3MST) in combination with aspartate aminotransferase (AAT) (also called as cysteine aminotransferase, CAT); on the other hand, H2S is produced from D-cysteine by enzymes of D-amino acid oxidase (DAO). Besides sulfide salt, several sulfide-releasing compounds have been synthesized, including organosulfur compounds, Lawesson's reagent and analogs, and plant-derived natural products. Based on garlic extractions, we synthesized S-propargyl-L-cysteine (SPRC) and its analogs to contribute our endeavors on drug development of sulfide-containing compounds. A multitude of evidences has presented H2S is widely involved in the roles of physiological and pathological process, including hypertension, atherosclerosis, angiogenesis, and myocardial infarcts. This review summarizes current sulfide compounds, available H2S measurements, and potential molecular mechanisms involved in cardioprotections to help researchers develop further applications and therapeutically drugs.

Authors+Show Affiliations

Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China. Hunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University, Changsha, China. Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Singapore Nuclear Research and Safety Initiative, National University of Singapore, Singapore.Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Department of Pharmacology, Macau University of Science and Technology, Macau.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30151069

Citation

Wen, Ya-Dan, et al. "The Drug Developments of Hydrogen Sulfide On Cardiovascular Disease." Oxidative Medicine and Cellular Longevity, vol. 2018, 2018, p. 4010395.
Wen YD, Wang H, Zhu YZ. The Drug Developments of Hydrogen Sulfide on Cardiovascular Disease. Oxid Med Cell Longev. 2018;2018:4010395.
Wen, Y. D., Wang, H., & Zhu, Y. Z. (2018). The Drug Developments of Hydrogen Sulfide on Cardiovascular Disease. Oxidative Medicine and Cellular Longevity, 2018, 4010395. https://doi.org/10.1155/2018/4010395
Wen YD, Wang H, Zhu YZ. The Drug Developments of Hydrogen Sulfide On Cardiovascular Disease. Oxid Med Cell Longev. 2018;2018:4010395. PubMed PMID: 30151069.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Drug Developments of Hydrogen Sulfide on Cardiovascular Disease. AU - Wen,Ya-Dan, AU - Wang,Hong, AU - Zhu,Yi-Zhun, Y1 - 2018/07/29/ PY - 2018/03/30/received PY - 2018/05/27/accepted PY - 2018/8/29/entrez PY - 2018/8/29/pubmed PY - 2018/12/12/medline SP - 4010395 EP - 4010395 JF - Oxidative medicine and cellular longevity JO - Oxid Med Cell Longev VL - 2018 N2 - The recognition of hydrogen sulfide (H2S) has been evolved from a toxic gas to a physiological mediator, exhibiting properties similar to NO and CO. On the one hand, H2S is produced from L-cysteine by enzymes of cystathionine γ-lyase (CSE) and cystathionine β-synthase (CBS), 3-mercaptopyruvate sulfurtransferase (3MST) in combination with aspartate aminotransferase (AAT) (also called as cysteine aminotransferase, CAT); on the other hand, H2S is produced from D-cysteine by enzymes of D-amino acid oxidase (DAO). Besides sulfide salt, several sulfide-releasing compounds have been synthesized, including organosulfur compounds, Lawesson's reagent and analogs, and plant-derived natural products. Based on garlic extractions, we synthesized S-propargyl-L-cysteine (SPRC) and its analogs to contribute our endeavors on drug development of sulfide-containing compounds. A multitude of evidences has presented H2S is widely involved in the roles of physiological and pathological process, including hypertension, atherosclerosis, angiogenesis, and myocardial infarcts. This review summarizes current sulfide compounds, available H2S measurements, and potential molecular mechanisms involved in cardioprotections to help researchers develop further applications and therapeutically drugs. SN - 1942-0994 UR - https://www.unboundmedicine.com/medline/citation/30151069/The_Drug_Developments_of_Hydrogen_Sulfide_on_Cardiovascular_Disease_ L2 - https://doi.org/10.1155/2018/4010395 DB - PRIME DP - Unbound Medicine ER -
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