Tags

Type your tag names separated by a space and hit enter

Susceptibility vessel sign on MRI predicts better clinical outcome in patients with anterior circulation acute stroke treated with stent retriever as first-line strategy.
J Neurointerv Surg 2019; 11(4):328-333JN

Abstract

BACKGROUND

Susceptibility vessel sign (SVS) can be a useful MRI biomarker of an occlusion but its relationship with clinical outcomes of acute ischemic stroke (AIS) is yet to be fully elucidated.

OBJECTIVE

To investigate SVS in relation to the clinical outcomes after mechanical thrombectomy using a stent retriever (SR) as first-line approach in patients with AIS.

MATERIAL AND METHODS

We included patients with a first-line SR approach for anterior AIS from the the Contact Aspiration vs Stent Retriever for Successful Revascularization (ASTER) and THRombectomie des Artères CErebrales (THRACE) trials when both baseline imaging of SVS and 90-day modified Rankin Scale (mRS) scores were available. Patients were assigned to two groups based on the presence of an SVS (independent core laboratory), and the overall distributions of the mRS score at 90 days (shift analysis) and clinical independence (mRS score ≤2) were compared.

RESULTS

217 patients were included and SVS was diagnosed in 76.0% of cases (n=165, 95% CI 70.4% to 81.7%). After adjustment for potential confounders, SVS+ was significantly associated with 90-day mRS improvement (adjusted common OR=2.75; 95% CI 1.44 to 5.26) and favorable outcome (adjusted common OR=2.76; 95% CI 1.18 to 6.45).

CONCLUSION

Based on results for patients of the ASTER and THRACE trials receiving first-line SR treatment, SVS was associated with lower disability at 3 months. Large prospective studies using MRI-based thrombus evaluation are warranted.

Authors+Show Affiliations

Department of Diagnostic and Interventional Neuroradiology, Guillaume et René Laennec University Hospital, Nantes, France.Department of Neuroradiology, Université Paris<Descartes. INSERM U894, Sainte Anne Hospital, Paris, France.Department of Diagnostic and Interventional Neuroradiology, University Hospital of Reims, Reims, France. INSERM UMR<S 1237 Physiopathology and Imaging of Neurological Disorders, Université Caen Normandie, Caen, France.Department of Diagnostic and Interventional Neuroradiology, Rothschild Foundation, Paris, France.Department of Biostatistics, University Lille, CHU Lille, EA 2694-Santé Publique: Epidémiologie et Qualité des Soins, Lille, France.Department of Biostatistics, University Lille, CHU Lille, EA 2694-Santé Publique: Epidémiologie et Qualité des Soins, Lille, France.Department of Stroke Center and Diagnostic and Interventional Neuroradiology, University of Versailles and Saint Quentin en Yvelines, Foch Hospital, Suresnes, France.Urgences cérébro-vasculaires, Sorbonne Université, UPMC Univ Paris 06, Hôpital Pitié<Salpêtrière, Paris, France.Department of Diagnostic and Interventional Neuroradiology, Rothschild Foundation, Paris, France.Department of Diagnostic and Interventional Neuroradiology, Rothschild Foundation, Paris, France.Department of Diagnostic and Interventional Neuroradiology, Hôpital Gui de Chauliac, Montpellier, France.Department of Neuroradiology, Université Paris<Descartes. INSERM U894, Sainte Anne Hospital, Paris, France.Department of Neuroradiology, Université Paris<Descartes. INSERM U894, Sainte Anne Hospital, Paris, France.Department of Diagnostic and Interventional Neuroradiology, Guillaume et René Laennec University Hospital, Nantes, France.Department of Diagnostic and Interventional Neuroradiology, University Hospital of Nancy, Nancy, France.Department of Stroke Center and Diagnostic and Interventional Neuroradiology, University of Versailles and Saint Quentin en Yvelines, Foch Hospital, Suresnes, France.Department of Neuroradiology, Université Paris<Descartes. INSERM U894, Sainte Anne Hospital, Paris, France. Pediatric Radiology Department, Necker Enfants Mala des, Paris, France.No affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

30154254

Citation

Bourcier, Romain, et al. "Susceptibility Vessel Sign On MRI Predicts Better Clinical Outcome in Patients With Anterior Circulation Acute Stroke Treated With Stent Retriever as First-line Strategy." Journal of Neurointerventional Surgery, vol. 11, no. 4, 2019, pp. 328-333.
Bourcier R, Hassen WB, Soize S, et al. Susceptibility vessel sign on MRI predicts better clinical outcome in patients with anterior circulation acute stroke treated with stent retriever as first-line strategy. J Neurointerv Surg. 2019;11(4):328-333.
Bourcier, R., Hassen, W. B., Soize, S., Roux, P., Labreuche, J., Kyheng, M., ... Naggara, O. (2019). Susceptibility vessel sign on MRI predicts better clinical outcome in patients with anterior circulation acute stroke treated with stent retriever as first-line strategy. Journal of Neurointerventional Surgery, 11(4), pp. 328-333. doi:10.1136/neurintsurg-2018-014217.
Bourcier R, et al. Susceptibility Vessel Sign On MRI Predicts Better Clinical Outcome in Patients With Anterior Circulation Acute Stroke Treated With Stent Retriever as First-line Strategy. J Neurointerv Surg. 2019;11(4):328-333. PubMed PMID: 30154254.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Susceptibility vessel sign on MRI predicts better clinical outcome in patients with anterior circulation acute stroke treated with stent retriever as first-line strategy. AU - Bourcier,Romain, AU - Hassen,Wagih Ben, AU - Soize,Sébastien, AU - Roux,Pascal, AU - Labreuche,Julien, AU - Kyheng,Maeva, AU - Tisserand,Marie, AU - Rosso,Charlotte, AU - Blanc,Raphael, AU - Piotin,Michel, AU - Derraz,Imad, AU - Boulouis,Gregoire, AU - Oppenheim,Catherine, AU - Desal,Hubert, AU - Bracard,Serge, AU - Lapergue,Bertrand, AU - Naggara,Olivier, AU - ,, Y1 - 2018/08/28/ PY - 2018/06/25/received PY - 2018/07/18/revised PY - 2018/07/21/accepted PY - 2018/8/30/pubmed PY - 2019/5/15/medline PY - 2018/8/30/entrez KW - mri KW - stroke KW - thrombectomy SP - 328 EP - 333 JF - Journal of neurointerventional surgery JO - J Neurointerv Surg VL - 11 IS - 4 N2 - BACKGROUND: Susceptibility vessel sign (SVS) can be a useful MRI biomarker of an occlusion but its relationship with clinical outcomes of acute ischemic stroke (AIS) is yet to be fully elucidated. OBJECTIVE: To investigate SVS in relation to the clinical outcomes after mechanical thrombectomy using a stent retriever (SR) as first-line approach in patients with AIS. MATERIAL AND METHODS: We included patients with a first-line SR approach for anterior AIS from the the Contact Aspiration vs Stent Retriever for Successful Revascularization (ASTER) and THRombectomie des Artères CErebrales (THRACE) trials when both baseline imaging of SVS and 90-day modified Rankin Scale (mRS) scores were available. Patients were assigned to two groups based on the presence of an SVS (independent core laboratory), and the overall distributions of the mRS score at 90 days (shift analysis) and clinical independence (mRS score ≤2) were compared. RESULTS: 217 patients were included and SVS was diagnosed in 76.0% of cases (n=165, 95% CI 70.4% to 81.7%). After adjustment for potential confounders, SVS+ was significantly associated with 90-day mRS improvement (adjusted common OR=2.75; 95% CI 1.44 to 5.26) and favorable outcome (adjusted common OR=2.76; 95% CI 1.18 to 6.45). CONCLUSION: Based on results for patients of the ASTER and THRACE trials receiving first-line SR treatment, SVS was associated with lower disability at 3 months. Large prospective studies using MRI-based thrombus evaluation are warranted. SN - 1759-8486 UR - https://www.unboundmedicine.com/medline/citation/30154254/Susceptibility_vessel_sign_on_MRI_predicts_better_clinical_outcome_in_patients_with_anterior_circulation_acute_stroke_treated_with_stent_retriever_as_first-line_strategy L2 - http://jnis.bmj.com/cgi/pmidlookup?view=long&amp;pmid=30154254 DB - PRIME DP - Unbound Medicine ER -