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Effect of short- and long-term dexamethasone on 3 alpha-androstanediol glucuronide in hirsute women.
Fertil Steril. 1986 Aug; 46(2):227-31.FS

Abstract

The role of glucocorticoid therapy in regulating plasma 3 alpha-androstanediol glucuronide (3 alpha-diol G) content, a marker of androgen action, in hirsute women was unclear. A pulse injection of adrenocorticotropic hormone (0.5 U) following 1 mg of dexamethasone (DEX) at midnight significantly increased the plasma level of cortisol (P less than 0.01), 17-hydroxyprogesterone (17-OHP, P less than 0.01) in 17 hirsute women, but it had an insignificant effect on delta 4-androstenedione (delta 4A), testosterone, dehydroepiandrosterone sulfate (DHEA-S), and 3 alpha-diol G. Human chorionic gonadotropin administered for 3 days produced a significant (P less than 0.01) increase only in 17-OHP. DEX administered as a single dose in the late evening failed to affect the plasma levels of these four androgens when measured at 8:00 A.M. In contrast, when the glucocorticoid was given each evening for over 2 months, plasma delta 4A, DHEA-S, and 3 alpha-diol G were suppressed (P less than 0.001) substantially, as compared with baseline values in 12 hirsute women, 7 with polycystic ovary disease and 5 with idiopathic hirsutism. These observations indicate that chronic glucocorticoid therapy suppresses androgen action in hirsute women.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3015694

Citation

Meikle, A W., and W D. Odell. "Effect of Short- and Long-term Dexamethasone On 3 Alpha-androstanediol Glucuronide in Hirsute Women." Fertility and Sterility, vol. 46, no. 2, 1986, pp. 227-31.
Meikle AW, Odell WD. Effect of short- and long-term dexamethasone on 3 alpha-androstanediol glucuronide in hirsute women. Fertil Steril. 1986;46(2):227-31.
Meikle, A. W., & Odell, W. D. (1986). Effect of short- and long-term dexamethasone on 3 alpha-androstanediol glucuronide in hirsute women. Fertility and Sterility, 46(2), 227-31.
Meikle AW, Odell WD. Effect of Short- and Long-term Dexamethasone On 3 Alpha-androstanediol Glucuronide in Hirsute Women. Fertil Steril. 1986;46(2):227-31. PubMed PMID: 3015694.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of short- and long-term dexamethasone on 3 alpha-androstanediol glucuronide in hirsute women. AU - Meikle,A W, AU - Odell,W D, PY - 1986/8/1/pubmed PY - 1986/8/1/medline PY - 1986/8/1/entrez SP - 227 EP - 31 JF - Fertility and sterility JO - Fertil Steril VL - 46 IS - 2 N2 - The role of glucocorticoid therapy in regulating plasma 3 alpha-androstanediol glucuronide (3 alpha-diol G) content, a marker of androgen action, in hirsute women was unclear. A pulse injection of adrenocorticotropic hormone (0.5 U) following 1 mg of dexamethasone (DEX) at midnight significantly increased the plasma level of cortisol (P less than 0.01), 17-hydroxyprogesterone (17-OHP, P less than 0.01) in 17 hirsute women, but it had an insignificant effect on delta 4-androstenedione (delta 4A), testosterone, dehydroepiandrosterone sulfate (DHEA-S), and 3 alpha-diol G. Human chorionic gonadotropin administered for 3 days produced a significant (P less than 0.01) increase only in 17-OHP. DEX administered as a single dose in the late evening failed to affect the plasma levels of these four androgens when measured at 8:00 A.M. In contrast, when the glucocorticoid was given each evening for over 2 months, plasma delta 4A, DHEA-S, and 3 alpha-diol G were suppressed (P less than 0.001) substantially, as compared with baseline values in 12 hirsute women, 7 with polycystic ovary disease and 5 with idiopathic hirsutism. These observations indicate that chronic glucocorticoid therapy suppresses androgen action in hirsute women. SN - 0015-0282 UR - https://www.unboundmedicine.com/medline/citation/3015694/Effect_of_short__and_long_term_dexamethasone_on_3_alpha_androstanediol_glucuronide_in_hirsute_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(16)49516-6 DB - PRIME DP - Unbound Medicine ER -