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The risk profile of rhegmatogenous retinal detachment before and after using a fluoroquinolone: a 12 year nationwide self-controlled case series study.
J Antimicrob Chemother. 2018 12 01; 73(12):3442-3453.JA

Abstract

Objectives

To determine whether or not fluoroquinolone use increases the incidence of retinal detachment.

Design

Self-controlled case series analysis.

Participants

Participants were identified using the South Korean National Health Insurance Database between 1 January 2004 and 31 December 2015. A total of 15 134 patients who experienced rhegmatogenous retinal detachment (RRD) with at least one prescription of a fluoroquinolone were included.

Methods

Incidence rate ratios (IRRs) and their 95% CIs were calculated using conditional Poisson regression. The main outcome measure was a recorded diagnosis of RRD (ICD-10: H33.0) with a claim for the surgical code for RRD.

Results

We found an increased risk of retinal detachment in the first 1-30 days following the initiation of fluoroquinolone therapy (IRR 1.85; 95% CI 1.71-1.95), which rose for the 31-60 days period (IRR 2.05; 95% CI 1.43-2.95) but remained constant after more than 60 days (IRR 1.25; 95% CI 0.75-2.10). However, the elevated risk was also found in the 1-30 day period prior to the initiation of fluoroquinolone therapy (IRR 1.58; 95% CI 1.49-1.68) and also 31-60 days before medication use (IRR 1.11; 95% CI 1.03-1.19).

Conclusions

Our case-based study indicated that the risk after fluoroquinolone exposure doubled; however, the risk profile before and after fluoroquinolone use means that the association between fluoroquinolone use and retinal detachment might not be a causal relationship.

Authors+Show Affiliations

School of Pharmacy, Sungkyunkwan University, Suwon, South Korea.School of Pharmacy, Sungkyunkwan University, Suwon, South Korea.School of Pharmacy, Sungkyunkwan University, Suwon, South Korea.School of Pharmacy, Sungkyunkwan University, Suwon, South Korea. Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.School of Pharmacy, Sungkyunkwan University, Suwon, South Korea.Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30165476

Citation

Shin, Ju-Young, et al. "The Risk Profile of Rhegmatogenous Retinal Detachment Before and After Using a Fluoroquinolone: a 12 Year Nationwide Self-controlled Case Series Study." The Journal of Antimicrobial Chemotherapy, vol. 73, no. 12, 2018, pp. 3442-3453.
Shin JY, Jeong S, Jeon HL, et al. The risk profile of rhegmatogenous retinal detachment before and after using a fluoroquinolone: a 12 year nationwide self-controlled case series study. J Antimicrob Chemother. 2018;73(12):3442-3453.
Shin, J. Y., Jeong, S., Jeon, H. L., Byun, S., Park, K. H., Jeong, H. E., & Park, S. J. (2018). The risk profile of rhegmatogenous retinal detachment before and after using a fluoroquinolone: a 12 year nationwide self-controlled case series study. The Journal of Antimicrobial Chemotherapy, 73(12), 3442-3453. https://doi.org/10.1093/jac/dky336
Shin JY, et al. The Risk Profile of Rhegmatogenous Retinal Detachment Before and After Using a Fluoroquinolone: a 12 Year Nationwide Self-controlled Case Series Study. J Antimicrob Chemother. 2018 12 1;73(12):3442-3453. PubMed PMID: 30165476.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The risk profile of rhegmatogenous retinal detachment before and after using a fluoroquinolone: a 12 year nationwide self-controlled case series study. AU - Shin,Ju-Young, AU - Jeong,Sohyun, AU - Jeon,Ha-Lim, AU - Byun,Seongjun, AU - Park,Kyu Hyung, AU - Jeong,Han Eol, AU - Park,Sang Jun, PY - 2018/03/16/received PY - 2018/07/23/accepted PY - 2018/8/31/pubmed PY - 2019/10/15/medline PY - 2018/8/31/entrez SP - 3442 EP - 3453 JF - The Journal of antimicrobial chemotherapy JO - J Antimicrob Chemother VL - 73 IS - 12 N2 - Objectives: To determine whether or not fluoroquinolone use increases the incidence of retinal detachment. Design: Self-controlled case series analysis. Participants: Participants were identified using the South Korean National Health Insurance Database between 1 January 2004 and 31 December 2015. A total of 15 134 patients who experienced rhegmatogenous retinal detachment (RRD) with at least one prescription of a fluoroquinolone were included. Methods: Incidence rate ratios (IRRs) and their 95% CIs were calculated using conditional Poisson regression. The main outcome measure was a recorded diagnosis of RRD (ICD-10: H33.0) with a claim for the surgical code for RRD. Results: We found an increased risk of retinal detachment in the first 1-30 days following the initiation of fluoroquinolone therapy (IRR 1.85; 95% CI 1.71-1.95), which rose for the 31-60 days period (IRR 2.05; 95% CI 1.43-2.95) but remained constant after more than 60 days (IRR 1.25; 95% CI 0.75-2.10). However, the elevated risk was also found in the 1-30 day period prior to the initiation of fluoroquinolone therapy (IRR 1.58; 95% CI 1.49-1.68) and also 31-60 days before medication use (IRR 1.11; 95% CI 1.03-1.19). Conclusions: Our case-based study indicated that the risk after fluoroquinolone exposure doubled; however, the risk profile before and after fluoroquinolone use means that the association between fluoroquinolone use and retinal detachment might not be a causal relationship. SN - 1460-2091 UR - https://www.unboundmedicine.com/medline/citation/30165476/The_risk_profile_of_rhegmatogenous_retinal_detachment_before_and_after_using_a_fluoroquinolone:_a_12_year_nationwide_self_controlled_case_series_study_ L2 - https://academic.oup.com/jac/article-lookup/doi/10.1093/jac/dky336 DB - PRIME DP - Unbound Medicine ER -