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Immunohistochemical Cross-Reactivity Between Paracoccidioides sp. from Dolphins and Histoplasma capsulatum.
Mycopathologia. 2018 Oct; 183(5):793-803.M

Abstract

Paracoccidioidomycosis ceti is a cutaneous disease of cetaceans caused by uncultivated Paracoccidioides brasiliensis or Paracoccidioides spp. Serological cross-reactions between paracoccidioidomycosis ceti and paracoccidioidomycosis, paracoccidioidomycosis and histoplasmosis, and paracoccidioidomycosis and coccidioidomycosis have been reported before. The present study aimed to detect immunohistochemical cross-reaction between antibodies to Paracoccidioides sp. and Histoplasma capsulatum, and vice versa. Thirty murine sera, obtained from experimental infections of 6 isolates of H. capsulatum, were reacted with paraffin-embedded yeast-form cells of Paracoccidioides sp. derived from a case of paracoccidioidomycosis ceti in Japan. The murine sera were also reacted with human isolates of H. capsulatum yeast cells, with P. brasiliensis yeast cells, and with fungal cells of Coccidioides posadasii. Three dolphins' sera from cases of paracoccidioidomycosis ceti, two human sera from patients with paracoccidioidomycosis, and a serum from a healthy person with a history of coccidioidomycosis were used in order to determine that the tested fungal cells reacted properly. Sera derived from mice infected with an isolate of H. capsulatum reacted positively against yeast cells of Paracoccidioides sp., yeast cells of P. brasiliensis, and fungal cells of C. posadasii, while those derived from other strains were negative. The present study recorded for the first time the cross-reaction between the yeast cells of H. capsulatum and antibodies against Paracoccidioides spp., the yeast cells of Paracoccidioides sp. and antibodies against H. capsulatum, the yeast cells of Paracoccidioides sp. and antibodies against Coccidioides sp., and fungal cells of C. posadasii and antibodies against Paracoccidioides spp.

Authors+Show Affiliations

Ryukyu Animal Medical Center, Yone 5-27, Tomigusuku, Okinawa, 901-0224, Japan. The United Graduate School of Agriculture Sciences, Kagoshima University, Kagoshima, 890-0065, Japan. Department of Animal Sciences, Faculty of Agriculture, University of the Ryukyus, Sembaru 1, Nishihara-Cho, Nakagusuku-Gun, Okinawa, 903-0213, Japan.Okinawa Churashima Foundation, Aza Ishikawa 888, Motobu-Cho, Kunigami-Gun, Okinawa, 905-0206, Japan.Department of Dermatology, Faculty of Medicine, University of the Ryukyus, Uehara, Nishihara, Nakagusuku-Gun, Okinawa, 903-0215, Japan.Ryukyu Animal Medical Center, Yone 5-27, Tomigusuku, Okinawa, 901-0224, Japan.The United Graduate School of Agriculture Sciences, Kagoshima University, Kagoshima, 890-0065, Japan. Department of Animal Sciences, Faculty of Agriculture, University of the Ryukyus, Sembaru 1, Nishihara-Cho, Nakagusuku-Gun, Okinawa, 903-0213, Japan. Tropical Bioresources Research Center, University of the Ryukyus, Sembaru 1, Nishihara-Cho, Nakagusuku-Gun, Okinawa, 903-0213, Japan.The United Graduate School of Agriculture Sciences, Kagoshima University, Kagoshima, 890-0065, Japan. Tropical Bioresources Research Center, University of the Ryukyus, Sembaru 1, Nishihara-Cho, Nakagusuku-Gun, Okinawa, 903-0213, Japan.The United Graduate School of Agriculture Sciences, Kagoshima University, Kagoshima, 890-0065, Japan. Faculty of Fisheries, Kagoshima University, Shimoarata 4-50-20, Kagoshima, 890-0056, Japan.Institute of Technology of Parana, Rua Joao Americo de Oliveira, 330, Curitiba, Parana, 80030-060, Brazil.Department of Pathological Science, CCB, State University of Londrina, P.O. Box 6001, Londrina, PR, 86051-970, Brazil.Ryukyu Animal Medical Center, Yone 5-27, Tomigusuku, Okinawa, 901-0224, Japan. aya_grimalkin@yahoo.co.jp. The United Graduate School of Agriculture Sciences, Kagoshima University, Kagoshima, 890-0065, Japan. aya_grimalkin@yahoo.co.jp. Department of Animal Sciences, Faculty of Agriculture, University of the Ryukyus, Sembaru 1, Nishihara-Cho, Nakagusuku-Gun, Okinawa, 903-0213, Japan. aya_grimalkin@yahoo.co.jp. Tropical Bioresources Research Center, University of the Ryukyus, Sembaru 1, Nishihara-Cho, Nakagusuku-Gun, Okinawa, 903-0213, Japan. aya_grimalkin@yahoo.co.jp.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30168080

Citation

Shumoto, Godai, et al. "Immunohistochemical Cross-Reactivity Between Paracoccidioides Sp. From Dolphins and Histoplasma Capsulatum." Mycopathologia, vol. 183, no. 5, 2018, pp. 793-803.
Shumoto G, Ueda K, Yamaguchi S, et al. Immunohistochemical Cross-Reactivity Between Paracoccidioides sp. from Dolphins and Histoplasma capsulatum. Mycopathologia. 2018;183(5):793-803.
Shumoto, G., Ueda, K., Yamaguchi, S., Kaneshima, T., Konno, T., Terashima, Y., Yamamoto, A., Nagashima, L. A., Itano, E. N., & Sano, A. (2018). Immunohistochemical Cross-Reactivity Between Paracoccidioides sp. from Dolphins and Histoplasma capsulatum. Mycopathologia, 183(5), 793-803. https://doi.org/10.1007/s11046-018-0295-0
Shumoto G, et al. Immunohistochemical Cross-Reactivity Between Paracoccidioides Sp. From Dolphins and Histoplasma Capsulatum. Mycopathologia. 2018;183(5):793-803. PubMed PMID: 30168080.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunohistochemical Cross-Reactivity Between Paracoccidioides sp. from Dolphins and Histoplasma capsulatum. AU - Shumoto,Godai, AU - Ueda,Keiichi, AU - Yamaguchi,Sayaka, AU - Kaneshima,Takashi, AU - Konno,Toshihiro, AU - Terashima,Yoshie, AU - Yamamoto,Atsushi, AU - Nagashima,Luciene A, AU - Itano,Eiko N, AU - Sano,Ayako, Y1 - 2018/08/30/ PY - 2018/04/19/received PY - 2018/08/18/accepted PY - 2018/9/1/pubmed PY - 2018/11/10/medline PY - 2018/9/1/entrez KW - Coccidioidomycosis KW - Cross-reaction KW - Histoplasmosis KW - Paracoccidioidomycosis KW - Paracoccidioidomycosis ceti SP - 793 EP - 803 JF - Mycopathologia JO - Mycopathologia VL - 183 IS - 5 N2 - Paracoccidioidomycosis ceti is a cutaneous disease of cetaceans caused by uncultivated Paracoccidioides brasiliensis or Paracoccidioides spp. Serological cross-reactions between paracoccidioidomycosis ceti and paracoccidioidomycosis, paracoccidioidomycosis and histoplasmosis, and paracoccidioidomycosis and coccidioidomycosis have been reported before. The present study aimed to detect immunohistochemical cross-reaction between antibodies to Paracoccidioides sp. and Histoplasma capsulatum, and vice versa. Thirty murine sera, obtained from experimental infections of 6 isolates of H. capsulatum, were reacted with paraffin-embedded yeast-form cells of Paracoccidioides sp. derived from a case of paracoccidioidomycosis ceti in Japan. The murine sera were also reacted with human isolates of H. capsulatum yeast cells, with P. brasiliensis yeast cells, and with fungal cells of Coccidioides posadasii. Three dolphins' sera from cases of paracoccidioidomycosis ceti, two human sera from patients with paracoccidioidomycosis, and a serum from a healthy person with a history of coccidioidomycosis were used in order to determine that the tested fungal cells reacted properly. Sera derived from mice infected with an isolate of H. capsulatum reacted positively against yeast cells of Paracoccidioides sp., yeast cells of P. brasiliensis, and fungal cells of C. posadasii, while those derived from other strains were negative. The present study recorded for the first time the cross-reaction between the yeast cells of H. capsulatum and antibodies against Paracoccidioides spp., the yeast cells of Paracoccidioides sp. and antibodies against H. capsulatum, the yeast cells of Paracoccidioides sp. and antibodies against Coccidioides sp., and fungal cells of C. posadasii and antibodies against Paracoccidioides spp. SN - 1573-0832 UR - https://www.unboundmedicine.com/medline/citation/30168080/Immunohistochemical_Cross_Reactivity_Between_Paracoccidioides_sp__from_Dolphins_and_Histoplasma_capsulatum_ L2 - https://dx.doi.org/10.1007/s11046-018-0295-0 DB - PRIME DP - Unbound Medicine ER -