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[Impact of Mycoplasma genitalium infection on the semen quality of infertile males].
Zhonghua Nan Ke Xue. 2018 Apr; 24(4):317-321.ZN

Abstract

Objective

To explore Mycoplasma genitalium (MG) infection in the urogenital tract of infertile men and its influence on semen quality.

METHODS

Semen samples were collected from 352 infertile males in the Center of Reproductive Medicine of Nanjing General Hospital from March to July 2015. MG infection was detected by real-time fluorescence simultaneous amplification and testing and semen analyses were conducted according to the WHO Laboratory Manual for the Examination and Processing of Human Semen (5th Ed) on the semen pH value, semen volume, total sperm count, sperm concentration, total sperm motility, percentages of progressively motile sperm (PMS) and immotile sperm (IMS), and sperm DNA fragmentation index (DFI). The data obtained were subjected to statistical analysis by t-test and non-parametric test (Wilcoxon test).

RESULTS

MG infection was found in 3.4% (12/352) of the infertile patients. Compared with the MG-positive cases, the MG-negative ones showed a significantly higher semen volume ([2.85 ± 0.14] vs [3.84 ± 0.12] ml, P = 0.008) and percentage of PMS ([15.86±1.72] vs [60.95 ± 5.63] %, P = 0.032) but a lower DFI ([30.73 ±2.24] vs [20.71 ± 1.55]%, P = 0.014). However, no statistically significant differences were observed between the two groups in the semen pH value (7.38 ±0.02 vs 7.39 ± 0.01, P = 0.774), sperm concentration ([52.96 ± 15.78] vs [60.05 ± 4.29]×10⁶/ml, P = 0.683), sperm count ([154.15 ± 46.37] vs [221.56 ± 15.43]×106, P = 0.236), total sperm motility ([29.04 ± 3.11] vs [33.52 ± 1.51] %, P = 0.626), or percentage of IMS ([23.57 ± 0.99] vs [62.34 ± 1.69] %, P = 0.691).

CONCLUSIONS

Urogenital MG infection is common in infertile males and potentially affects the semen quality, especially sperm vitality of the patient.

Authors+Show Affiliations

Department of Surgery, the First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450052, China.Department of Andrology, Nanjing School of Clinical Medicine, Southern Medical University / Nanjing General Hospital of Nanjing Military Region, Nanjing, Jiangsu 210002, China.Department of Andrology, Nanjing School of Clinical Medicine, Southern Medical University / Nanjing General Hospital of Nanjing Military Region, Nanjing, Jiangsu 210002, China.Virtual Laboratory Section, Laboratory of Human Integrated Biological Functions, School of Basic Medicine, Qingdao University, Qingdao, Shandong 266071, China.Department of Clinical Laboratory, Jinhu People's Hospital, Jinhu, Jiangsu 211600, China.Department of Urology,Nanjing School of Clinical Medicine, Southern Medical University / Nanjing General Hospital of Nanjing Military Region, Nanjing, Jiangsu 210002, China.Department of Outpatients, Nanjing School of Clinical Medicine, Southern Medical University / Nanjing General Hospital of Nanjing Military Region, Nanjing, Jiangsu 210002, China.Department of Andrology, 5. Department of Urology, 6. Department of Outpatients, Nanjing School of Clinical Medicine, Southern Medical University / Nanjing General Hospital of Nanjing Military Region, Nanjing, Jiangsu 210002, China.

Pub Type(s)

Journal Article

Language

chi

PubMed ID

30168950

Citation

Yan, Ze-Chen, et al. "[Impact of Mycoplasma Genitalium Infection On the Semen Quality of Infertile Males]." Zhonghua Nan Ke Xue = National Journal of Andrology, vol. 24, no. 4, 2018, pp. 317-321.
Yan ZC, Shang XJ, Liu W, et al. [Impact of Mycoplasma genitalium infection on the semen quality of infertile males]. Zhonghua Nan Ke Xue. 2018;24(4):317-321.
Yan, Z. C., Shang, X. J., Liu, W., Wan, X. X., Wan, C. C., Xu, S., Zhong, Y., & Weng, Z. Q. (2018). [Impact of Mycoplasma genitalium infection on the semen quality of infertile males]. Zhonghua Nan Ke Xue = National Journal of Andrology, 24(4), 317-321.
Yan ZC, et al. [Impact of Mycoplasma Genitalium Infection On the Semen Quality of Infertile Males]. Zhonghua Nan Ke Xue. 2018;24(4):317-321. PubMed PMID: 30168950.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Impact of Mycoplasma genitalium infection on the semen quality of infertile males]. AU - Yan,Ze-Chen, AU - Shang,Xue-Jun, AU - Liu,Wei, AU - Wan,Xiu-Xia, AU - Wan,Chang-Chun, AU - Xu,Song, AU - Zhong,Yong, AU - Weng,Zhi-Qiang, PY - 2018/9/1/entrez PY - 2018/9/1/pubmed PY - 2018/12/18/medline KW - infertility KW - real-time fluorescence simultaneous amplification and testing KW - semen quality KW - Mycoplasma genitalium SP - 317 EP - 321 JF - Zhonghua nan ke xue = National journal of andrology JO - Zhonghua Nan Ke Xue VL - 24 IS - 4 N2 - Objective: To explore Mycoplasma genitalium (MG) infection in the urogenital tract of infertile men and its influence on semen quality. METHODS: Semen samples were collected from 352 infertile males in the Center of Reproductive Medicine of Nanjing General Hospital from March to July 2015. MG infection was detected by real-time fluorescence simultaneous amplification and testing and semen analyses were conducted according to the WHO Laboratory Manual for the Examination and Processing of Human Semen (5th Ed) on the semen pH value, semen volume, total sperm count, sperm concentration, total sperm motility, percentages of progressively motile sperm (PMS) and immotile sperm (IMS), and sperm DNA fragmentation index (DFI). The data obtained were subjected to statistical analysis by t-test and non-parametric test (Wilcoxon test). RESULTS: MG infection was found in 3.4% (12/352) of the infertile patients. Compared with the MG-positive cases, the MG-negative ones showed a significantly higher semen volume ([2.85 ± 0.14] vs [3.84 ± 0.12] ml, P = 0.008) and percentage of PMS ([15.86±1.72] vs [60.95 ± 5.63] %, P = 0.032) but a lower DFI ([30.73 ±2.24] vs [20.71 ± 1.55]%, P = 0.014). However, no statistically significant differences were observed between the two groups in the semen pH value (7.38 ±0.02 vs 7.39 ± 0.01, P = 0.774), sperm concentration ([52.96 ± 15.78] vs [60.05 ± 4.29]×10⁶/ml, P = 0.683), sperm count ([154.15 ± 46.37] vs [221.56 ± 15.43]×106, P = 0.236), total sperm motility ([29.04 ± 3.11] vs [33.52 ± 1.51] %, P = 0.626), or percentage of IMS ([23.57 ± 0.99] vs [62.34 ± 1.69] %, P = 0.691). CONCLUSIONS: Urogenital MG infection is common in infertile males and potentially affects the semen quality, especially sperm vitality of the patient. SN - 1009-3591 UR - https://www.unboundmedicine.com/medline/citation/30168950/[Impact_of_Mycoplasma_genitalium_infection_on_the_semen_quality_of_infertile_males]_ L2 - https://medlineplus.gov/maleinfertility.html DB - PRIME DP - Unbound Medicine ER -