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Case-control study of silicosis, silica exposure, and lung cancer in white South African gold miners.
Am J Ind Med 1986; 10(1):57-62AJ

Abstract

A case-control study was undertaken to assess the association between lung cancer and silicosis or silica dust exposure in white South African gold miners. Cases and controls were identified from deaths reported to the Gold Miners Provident Fund for the period January, 1979-October, 1983. Two controls were matched to each case by year of birth (+/- 2 years) and by smoking (+/- 5 cigarettes or equivalents per day) assessed 10 years (+/- 2 years) prior to death. One hundred thirty-three matched triplets were identified. The results showed no overall association between lung cancer and radiological silicosis (OR = 1.08, p = 0.92). Autopsy data indicated no overall associations between lung cancer and silicosis of the lung parenchyma (OR = 1.49, p = 0.11), the pleura (OR = 0.72, p = 0.30), or the hilar glands (OR = 0.85, p = 0.72). A trend toward increased severity of silicosis of the parenchyma was evident; however, this was not statistically significant (p = 0.08). Odds ratios for lung cancer and silicosis were higher at lower levels of cumulative silica dust exposure (ORs = 2.43, 1.72, 1.35 and 0.62 for lung cancer and autopsy silicosis of the parenchyma for the lowest, second, third, and highest quartiles of dust exposure, respectively; all p greater than 0.05). Cases did not differ from controls for total silica dust exposure, length of exposure, weighted average intensity of exposure, or number of shifts at high dust (all p greater than 0.20). The data do not support the hypothesis of a carcinogenic role for silica dust and no statistically significant associations were found between lung cancer and silicosis.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3017101

Citation

Hessel, P A., et al. "Case-control Study of Silicosis, Silica Exposure, and Lung Cancer in White South African Gold Miners." American Journal of Industrial Medicine, vol. 10, no. 1, 1986, pp. 57-62.
Hessel PA, Sluis-Cremer GK, Hnizdo E. Case-control study of silicosis, silica exposure, and lung cancer in white South African gold miners. Am J Ind Med. 1986;10(1):57-62.
Hessel, P. A., Sluis-Cremer, G. K., & Hnizdo, E. (1986). Case-control study of silicosis, silica exposure, and lung cancer in white South African gold miners. American Journal of Industrial Medicine, 10(1), pp. 57-62.
Hessel PA, Sluis-Cremer GK, Hnizdo E. Case-control Study of Silicosis, Silica Exposure, and Lung Cancer in White South African Gold Miners. Am J Ind Med. 1986;10(1):57-62. PubMed PMID: 3017101.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Case-control study of silicosis, silica exposure, and lung cancer in white South African gold miners. AU - Hessel,P A, AU - Sluis-Cremer,G K, AU - Hnizdo,E, PY - 1986/1/1/pubmed PY - 1986/1/1/medline PY - 1986/1/1/entrez SP - 57 EP - 62 JF - American journal of industrial medicine JO - Am. J. Ind. Med. VL - 10 IS - 1 N2 - A case-control study was undertaken to assess the association between lung cancer and silicosis or silica dust exposure in white South African gold miners. Cases and controls were identified from deaths reported to the Gold Miners Provident Fund for the period January, 1979-October, 1983. Two controls were matched to each case by year of birth (+/- 2 years) and by smoking (+/- 5 cigarettes or equivalents per day) assessed 10 years (+/- 2 years) prior to death. One hundred thirty-three matched triplets were identified. The results showed no overall association between lung cancer and radiological silicosis (OR = 1.08, p = 0.92). Autopsy data indicated no overall associations between lung cancer and silicosis of the lung parenchyma (OR = 1.49, p = 0.11), the pleura (OR = 0.72, p = 0.30), or the hilar glands (OR = 0.85, p = 0.72). A trend toward increased severity of silicosis of the parenchyma was evident; however, this was not statistically significant (p = 0.08). Odds ratios for lung cancer and silicosis were higher at lower levels of cumulative silica dust exposure (ORs = 2.43, 1.72, 1.35 and 0.62 for lung cancer and autopsy silicosis of the parenchyma for the lowest, second, third, and highest quartiles of dust exposure, respectively; all p greater than 0.05). Cases did not differ from controls for total silica dust exposure, length of exposure, weighted average intensity of exposure, or number of shifts at high dust (all p greater than 0.20). The data do not support the hypothesis of a carcinogenic role for silica dust and no statistically significant associations were found between lung cancer and silicosis.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0271-3586 UR - https://www.unboundmedicine.com/medline/citation/3017101/Case_control_study_of_silicosis_silica_exposure_and_lung_cancer_in_white_South_African_gold_miners_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0271-3586&date=1986&volume=10&issue=1&spage=57 DB - PRIME DP - Unbound Medicine ER -