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Identification of lignans and phytoestrogens in urine of chimpanzees.
Clin Chim Acta. 1986 Jul 30; 158(2):147-54.CC

Abstract

It was recently observed that the urinary excretion of animal lignans is low in postmenopausal breast cancer patients compared to normal omnivorous and vegetarian women. In addition, the mean excretion of the isoflavonic phytoestrogen equol tended to be lower. Because nonhuman primates appear to be remarkably resistant to the carcinogenic effect of estrogens, we investigated the possible occurrence of lignans and phytoestrogens in the urine of chimpanzees on their regular diet. Five major diphenols were isolated and identified by capillary gas chromatography and mass spectrometry by comparison with synthesized authentic reference compounds. Three of these compounds, the phytoestrogen equol and its precursor daidzein, the lignan enterolactone, were according to preliminary assays excreted in very large amounts. In addition, the lignan enterodiol and the daidzein metabolite O-desmethylangolensin were identified. It is concluded that the chimpanzee excretes both isoflavonic phytoestrogens and lignans in urine, apparently in high concentrations. It is suggested that these compounds may play a role in the maintenance of the resistance against carcinogenic effects of estrogens, which nonhuman primates possess, because both equol and enterolactone have been shown to have antiestrogenic properties in animals. However, much further work is necessary before the possible biological role of these compounds may be established.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3017606

Citation

Adlercreutz, H, et al. "Identification of Lignans and Phytoestrogens in Urine of Chimpanzees." Clinica Chimica Acta; International Journal of Clinical Chemistry, vol. 158, no. 2, 1986, pp. 147-54.
Adlercreutz H, Musey PI, Fotsis T, et al. Identification of lignans and phytoestrogens in urine of chimpanzees. Clin Chim Acta. 1986;158(2):147-54.
Adlercreutz, H., Musey, P. I., Fotsis, T., Bannwart, C., Wähälä, K., Mäkelä, T., Brunow, G., & Hase, T. (1986). Identification of lignans and phytoestrogens in urine of chimpanzees. Clinica Chimica Acta; International Journal of Clinical Chemistry, 158(2), 147-54.
Adlercreutz H, et al. Identification of Lignans and Phytoestrogens in Urine of Chimpanzees. Clin Chim Acta. 1986 Jul 30;158(2):147-54. PubMed PMID: 3017606.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Identification of lignans and phytoestrogens in urine of chimpanzees. AU - Adlercreutz,H, AU - Musey,P I, AU - Fotsis,T, AU - Bannwart,C, AU - Wähälä,K, AU - Mäkelä,T, AU - Brunow,G, AU - Hase,T, PY - 1986/7/30/pubmed PY - 1986/7/30/medline PY - 1986/7/30/entrez SP - 147 EP - 54 JF - Clinica chimica acta; international journal of clinical chemistry JO - Clin. Chim. Acta VL - 158 IS - 2 N2 - It was recently observed that the urinary excretion of animal lignans is low in postmenopausal breast cancer patients compared to normal omnivorous and vegetarian women. In addition, the mean excretion of the isoflavonic phytoestrogen equol tended to be lower. Because nonhuman primates appear to be remarkably resistant to the carcinogenic effect of estrogens, we investigated the possible occurrence of lignans and phytoestrogens in the urine of chimpanzees on their regular diet. Five major diphenols were isolated and identified by capillary gas chromatography and mass spectrometry by comparison with synthesized authentic reference compounds. Three of these compounds, the phytoestrogen equol and its precursor daidzein, the lignan enterolactone, were according to preliminary assays excreted in very large amounts. In addition, the lignan enterodiol and the daidzein metabolite O-desmethylangolensin were identified. It is concluded that the chimpanzee excretes both isoflavonic phytoestrogens and lignans in urine, apparently in high concentrations. It is suggested that these compounds may play a role in the maintenance of the resistance against carcinogenic effects of estrogens, which nonhuman primates possess, because both equol and enterolactone have been shown to have antiestrogenic properties in animals. However, much further work is necessary before the possible biological role of these compounds may be established. SN - 0009-8981 UR - https://www.unboundmedicine.com/medline/citation/3017606/Identification_of_lignans_and_phytoestrogens_in_urine_of_chimpanzees_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0009-8981(86)90230-5 DB - PRIME DP - Unbound Medicine ER -